• Proseek Multiplex Cardiometabolic

    Casting a broader net to further explore the complexity of the human proteome

    Complementing and expanding on our previous portfolio of disease area-focused biomarker panels, our exploratory panels offers scientists the chance to cast a wider net in the quest to identify new biomarkers and relevant protein signatures, offering many new assays focused on important biological processes with wide-ranging clinical relevance.

    The Cardiometabolic panel offers simultaneous analysis of 92 protein biomarkers using just 1 µL of biological sample, and all assays are subject to Olink’s strict technical validation and QC control procedures. The selection of protein biomarker assays is designed to provide the optimal dynamic range, as well as to focus on proteins with relevance for cardiometabolic processes. Categorization of the proteins included in the panel was carried out via referral to widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET. The assays in this panel include proteins involved in key biological processes such as cellular metabolic process, cell adhesion, immune response and complement activation.

    An alphabetical list of the 92 proteins with links to the individual biomarker pages containing additional information and assay validation data can be found at the bottom of this page.

    An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data.

    Biological Process

    Disease Area

    Tissue Expression

    Protein Class

     

    Please Note: the Cardiometabolic panel uses a 1:2025 dilution of sample, whereas our technical validation assays are performed in vitro using recombinant analytes. Technical validation data reported on the biomarker pages below, and in the data validation document for this panel are based on these in vitro assays. A multiplication factor of 2025 should therefore be taken into consideration when comparing the addressable biological concentration to the in vitro validation data. You can download the Sample Dilution Guideline for this panel here.

    A comprehensive list of all protein biomarkers that can be measured using the currently available biomarker panels can be seen on the biomarker library page.

    Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>

    If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.

    The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.

  • Search all our biomarkers

      Biomarkers in Cardiometabolic

      • Angiogenin (ANG)

        Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that cont...

      • Angiopoietin-related protein 3 (ANGPTL3)

        Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to pla...

      • Apolipoprotein M (APOM)

        Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.

      • Beta-Ala-His dipeptidase (CNDP1)

        No functional description currently available for this protein.

      • Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1)

        Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

      • C-C motif chemokine 14 (CCL14)

        Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at ...

      • C-C motif chemokine 18 (CCL18)

        Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lympho...

      • C-C motif chemokine 5 (CCL5)

        Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemok...

      • Cadherin-1 (CDH1)

        Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to...

      • Carbonic anhydrase 1 (CA1)

        Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.

      • Carbonic anhydrase 3 (CA3)

        Reversible hydration of carbon dioxide.

      • Carbonic anhydrase 4 (CA4)

        Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload remova...

      • Cartilage acidic protein 1 (CRTAC1)

        No functional description currently available for this protein.

      • Cartilage oligomeric matrix protein (COMP)

        May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the inte...

      • CD59 glycoprotein (CD59)

        Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation ...

      • Coagulation factor VII (F7)

        Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor...

      • Coagulation factor XI (F11)

        Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

      • Collagen alpha-1(XVIII) chain (COL18A1)

        COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferatio...

      • Complement C1q tumor necrosis factor-related protein 1 (C1QTNF1)

        No functional description currently available for this protein.

      • Complement C2 (C2)

        Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then comb...

      • Complement factor H-related protein 5 (CFHR5)

        Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.

      • Complement receptor type 2 (CR2)

        Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. (Microbial infection) Acts as a re...

      • Cystatin-C (CST3)

        As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

      • Dipeptidyl peptidase 4 (DPP4)

        Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell co...

      • EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)

        Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function...

      • Endoglin (ENG)

        Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RG...

      • Fetuin-B (FETUB)

        Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of A...

      • Ficolin-2 (FCN2)

        May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutr...

      • Glutaminyl-peptide cyclotransferase (QPCT)

        Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importan...

      • Granulysin (GNLY)

        Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kil...

      • Growth arrest-specific protein 6 (GAS6)

        Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling p...

      • Hepatocyte growth factor receptor (MET)

        Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological...

      • Ig lambda-2 chain C regions (IGLC2)

        No functional description currently available for this protein.

      • Insulin-like growth factor-binding protein 3 (IGFBP3)

        IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter th...

      • Insulin-like growth factor-binding protein 6 (IGFBP6)

        IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter th...

      • Integrin alpha-M (ITGAM)

        Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particl...

      • Intercellular adhesion molecule 1 (ICAM1)

        ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembl...

      • Intercellular adhesion molecule 3 (ICAM3)

        ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association...

      • Interleukin-7 receptor subunit alpha (IL7R)

        Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

      • L-selectin (SELL)

        Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and r...

      • Latent-transforming growth factor beta-binding protein 2 (LTBP2)

        May play an integral structural role in elastic-fiber architectural organization and/or assembly.

      • Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1)

        Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Lig...

      • Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2)

        Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the developme...

      • Leukocyte immunoglobulin-like receptor subfamily B member 5 (LILRB5)

        May act as receptor for class I MHC antigens.

      • Lithostathine-1-alpha (REG1A)

        Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

      • Liver carboxylesterase 1 (CES1)

        Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward a...

      • Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)

        Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagoc...

      • Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B)

        Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediat...

      • Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1)

        Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth re...

      • Lysosomal Pro-X carboxypeptidase (PRCP)

        Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is re...

      • Mannose-binding protein C (MBL2)

        Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway...

      • Mast/stem cell growth factor receptor Kit (KIT)

        Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoi...

      • Membrane cofactor protein (CD46)

        Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue...

      • Membrane primary amine oxidase (AOC3)

        Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells...

      • Metalloproteinase inhibitor 1 (TIMP1)

        Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to ...

      • Microfibrillar-associated protein 5 (MFAP5)

        May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similari...

      • Multiple epidermal growth factor-like domains protein 9 (MEGF9)

        No functional description currently available for this protein.

      • Neural cell adhesion molecule 1 (NCAM1)

        This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (Microbial infection) Acts as a receptor for rabi...

      • Neural cell adhesion molecule L1-like protein (CHL1)

        Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outg...

      • Neurogenic locus notch homolog protein 1 (NOTCH1)

        Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellul...

      • Neuropilin-1 (NRP1)

        The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organo...

      • Neutrophil defensin 1 (DEFA1)

        Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thou...

      • Neutrophil gelatinase-associated lipocalin (LCN2)

        Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (...

      • Nidogen-1 (NID1)

        Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extrac...

      • Oncostatin-M-specific receptor subunit beta (OSMR)

        Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.

      • Peptidyl-glycine alpha-amidating monooxygenase (PAM)

        Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermedi...

      • Phospholipid transfer protein (PLTP)

        Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cereb...

      • Plasma serine protease inhibitor (SERPINA5)

        Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved ...

      • Platelet glycoprotein Ib alpha chain (GP1BA)

        GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

      • Platelet-activating factor acetylhydrolase (PLA2G7)

        Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a ...

      • Plexin-B2 (PLXNB2)

        Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA an...

      • Procollagen C-endopeptidase enhancer 1 (PCOLCE)

        Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinas...

      • Prolyl endopeptidase FAP (FAP)

        Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wo...

      • Receptor-type tyrosine-protein phosphatase S (PTPRS)

        Interacts with LAR-interacting protein LIP.1.

      • Regenerating islet-derived protein 3-alpha (REG3A)

        Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidogly...

      • Serum amyloid A-4 protein (SAA4)

        Major acute phase reactant. Apolipoprotein of the HDL complex.

      • SPARC-like protein 1 (SPARCL1)

        No functional description currently available for this protein.

      • Superoxide dismutase [Cu-Zn] (SOD1)

        Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

      • T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)

        Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By s...

      • Tenascin (TNC)

        Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neur...

      • Tenascin-X (TNXB)

        Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril forma...

      • Thrombospondin-4 (THBS4)

        Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and a...

      • Thyroxine-binding globulin (SERPINA7)

        Major thyroid hormone transport protein in serum.

      • Transcobalamin-2 (TCN2)

        Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

      • Transforming growth factor beta receptor type 3 (TGFBR3)

        Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

      • Transforming growth factor-beta-induced protein ig-h3 (TGFBI)

        Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions (By similarity).

      • Trypsin-2 (PRSS2)

        In the ileum, may be involved in defensin processing, including DEFA5.

      • Tyrosine-protein kinase receptor Tie-1 (TIE1)

        Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.

      • Uromodulin (UMOD)

        Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation o...

      • Vascular cell adhesion protein 1 (VCAM1)

        Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates ...

      • Vasorin (VASN)

        May act as an inhibitor of TGF-beta signaling.

      • Vitamin K-dependent protein C (PROC)

        Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMe...