• Proseek Multiplex Cell Regulation

    Casting a broader net to further explore the complexity of the human proteome

    Complementing and expanding on our previous portfolio of disease area-focused biomarker panels, our exploratory panels offers scientists the chance to cast a wider net in the quest to identify new biomarkers and relevant protein signatures, offering many new assays focused on important biological processes with wide-ranging clinical relevance.

    The Cell Regulation panel offers simultaneous analysis of 92 protein biomarkers using just 1 µL of biological sample, and all assays are subject to Olink’s strict technical validation and QC control procedures. The selection of protein biomarker assays is designed to provide the optimal dynamic range, as well as to focus on proteins with relevance for cell regulation processes. Categorization of the proteins included in the panel was carried out via referral to widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET. The assays in this panel include proteins involved in key biological processes such as cell communication, apoptotic process, cell cycle and cell differentiation.

    An alphabetical list of the 92 proteins with links to the individual biomarker pages containing additional information and assay validation data can be found at the bottom of this page.

    An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data.

    Biological Process

    Disease Area

    Tissue Expression

    Protein Class

     

    A comprehensive list of all protein biomarkers that can be measured using the currently available biomarker panels can be seen on the biomarker library page.

    Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>

    If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.

    The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.

  • Search all our biomarkers

      Biomarkers in Cell Regulation

      • Amphoterin-induced protein 2 (AMIGO2)

        Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3...

      • Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP)

        Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates...

      • Anterior gradient protein 3 (AGR3)

        Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in trach...

      • Arylsulfatase B (ARSB)

        Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion...

      • ATP-dependent 6-phosphofructokinase, muscle type (PFKM)

        Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

      • Bcl-2-like protein 11 isoform BimL (BCL2L11)

        Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less pote...

      • Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)

        Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core...

      • Biglycan (BGN)

        May be involved in collagen fiber assembly.

      • Bile salt sulfotransferase (SULT2A1)

        Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

      • Breakpoint cluster region protein (BCR)

        GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

      • Brother of CDO (BOC)

        Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

      • C-type mannose receptor 2 (MRC2)

        May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an end...

      • Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1)

        Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK...

      • Calsyntenin-3 (CLSTN3)

        May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secreti...

      • Cell growth-regulating nucleolar protein (LYAR)

        No functional description currently available for this protein.

      • Cellular tumor antigen p53 (TP53)

        Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation ...

      • Cerebral dopamine neurotrophic factor (CDNF)

        Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the...

      • Collagen alpha-1(IV) chain (COL4A1)

        Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nid...

      • Cone-rod homeobox protein (CRX)

        Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts ...

      • Cryptic protein (CFC1)

        NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.

      • Cysteine protease ATG4A (ATG4A)

        Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. ...

      • Cysteine-rich secretory protein 2 (CRISP2)

        May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.

      • Dickkopf-like protein 1 (DKKL1)

        No functional description currently available for this protein.

      • Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)

        No functional description currently available for this protein.

      • DnaJ homolog subfamily B member 1 (DNAJB1)

        Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.

      • Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

        Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation o...

      • Dynactin subunit 2 (DCTN2)

        Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microt...

      • E3 ubiquitin-protein ligase CBL (CBL)

        Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein lig...

      • Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6)

        Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially...

      • Fibroblast growth factor 21 (FGF21)

        Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the ...

      • Friend leukemia integration 1 transcription factor (FLI1)

        Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

      • Galectin-7 (LGALS7)

        Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activati...

      • Gamma-secretase-activating protein (GSAP)

        Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecti...

      • Gastrokine (GKN1)

        Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.

      • GDNF family receptor alpha-2 (GFRA2)

        Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase rec...

      • Glucagon (GCG)

        Please note that the antibodies used in this assay are specific for the GLP-1 cleavage peptide of pro-glucagon. GLP-1 is a potent stimulator of glucose-dependent insulin release...

      • Growth hormone variant (GH2)

        Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differe...

      • Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1)

        Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic a...

      • Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1)

        6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan...

      • Immunoglobulin superfamily member 3 (IGSF3)

        IGSF3 is an immunoglobulin-like membrane protein containing several V-type Ig-like domains.

      • Interleukin-17 receptor B (IL17RB)

        Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

      • Kallikrein-12 (KLK12)

        No functional description currently available for this protein.

      • Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1)

        Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity).

      • Leucine-rich repeat neuronal protein 1 (LRRN1)

        No functional description currently available for this protein.

      • Ly6/PLAUR domain-containing protein 1 (LYPD1)

        No functional description currently available for this protein.

      • Lymphoid-restricted membrane protein (LRMP)

        Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-indep...

      • Methionine aminopeptidase 1D, mitochondrial (METAP1D)

        Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-A...

      • Myelin-oligodendrocyte glycoprotein (MOG)

        Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-c...

      • N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)

        Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide gener...

      • NF-kappa-B inhibitor epsilon (NFKBIE)

        Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

      • Nicalin (NCLN)

        May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

      • Ninjurin-1 (NINJ1)

        Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires d...

      • Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)

        Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embry...

      • Oligodendrocyte-myelin glycoprotein (OMG)

        Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

      • Opticin (OPTC)

        Binds collagen fibrils.

      • Peroxiredoxin-6 (PRDX6)

        Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phosphol...

      • Podocalyxin-like protein 2 (PODXL2)

        Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and...

      • Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2)

        Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein rece...

      • Probable carboxypeptidase X1 (CPXM1)

        May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

      • Prokineticin-1 (PROK1)

        Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial ce...

      • Prolactin regulatory element-binding protein (PREB)

        Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulu...

      • Protein FAM19A5 (FAM19A5)

        No functional description currently available for this protein.

      • Protein Wnt-9a (WNT9A)

        Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete...

      • Protocadherin-17 (PCDH17)

        Potential calcium-dependent cell-adhesion protein.

      • Ras GTPase-activating-like protein IQGAP2 (IQGAP2)

        Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

      • Regulator of G-protein signaling 8 (RGS8)

        Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits sig...

      • Rho GTPase-activating protein 1 (ARHGAP1)

        GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

      • Rho guanine nucleotide exchange factor 12 (ARHGEF12)

        May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA G...

      • Seizure 6-like protein 2 (SEZ6L2)

        May contribute to specialized endoplasmic reticulum functions in neurons.

      • Semaphorin-4C (SEMA4C)

        Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at Tyr-1...

      • Serine/threonine-protein kinase PAK 4 (PAK4)

        Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell s...

      • Sialic acid-binding Ig-like lectin 10 (SIGLEC10)

        Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition ...

      • Sialic acid-binding Ig-like lectin 6 (SIGLEC6)

        Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis int...

      • SLAM family member 8 (SLAMF8)

        May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

      • SLIT and NTRK-like protein 2 (SLITRK2)

        Suppresses neurite outgrowth.

      • SLIT and NTRK-like protein 6 (SLITRK6)

        Regulator of neurite outgrowth required for normal hearing and vision.

      • Src kinase-associated phosphoprotein 1 (SKAP1)

        Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting th...

      • Syntaxin-16 (STX16)

        SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

      • Syntaxin-6 (STX6)

        Involved in intracellular vesicle trafficking.

      • T-cell leukemia/lymphoma protein 1B (TCL1B)

        Enhances the phosphorylation and activation of AKT1 and AKT2.

      • Transcription factor AP-1 (JUN)

        Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased ster...

      • Transforming acidic coiled-coil-containing protein 3 (TACC3)

        Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration ...

      • Tudor and KH domain-containing protein (TDRKH)

        Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential f...

      • Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

        Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) pe...

      • Tumor-associated calcium signal transducer 2 (TACSTD2)

        May function as a growth factor receptor.

      • Vascular endothelial growth factor D (VEGFD)

        Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of bl...

      • Vesicle-associated membrane protein 5 (VAMP5)

        May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.

      • VPS10 domain-containing receptor SorCS2 (SORCS2)

        No functional description currently available for this protein.

      • Wiskott-Aldrich syndrome protein family member 1 (WASF1)

        Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin fila...

      • Wiskott-Aldrich syndrome protein family member 3 (WASF3)

        Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation ...

      • Zinc finger and BTB domain-containing protein 16 (ZBTB16)

        Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition co...

      • Zinc finger and BTB domain-containing protein 17 (ZBTB17)

        Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a cr...