• Complete biomarker list

    See all of our currently available biomarker assays

    The total number of different biomarker assays currently available via our 12  panels = 981 – with more to come! You can browse or search this complete list here, or alternatively, see all the biomarkers available in a specific panel by going to the individual panel product page (using the links in the navigation to the left).

    Note on nomenclature: where proteins have multiple synonyms, the long and short names given below are generally those recommended by Uniprot. To see all of the synonyms that may apply to a given marker, visit the Uniprot website and search using the unique Uniprot ID number listed for the protein.

    The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.

  • Search all our biomarkers

      • [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) in Organ Damage Panel - Q9P0J1

        Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

      • 2,4-dienoyl-CoA reductase, mitochondrial (DECR1) in CVD II panel - Q16698

        This protein is an auxiliary enzyme in beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters that have double bonds in both even- and odd-numbe...

      • 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) in Organ Damage Panel - Q9Y478

        Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to redu...

      • 5'-nucleotidase (5'-NT) in Oncology panel - P21589

        5'-nucleotidase, also known as CD73 (Cluster of Differentiation 73), is an enzyme that hydrolyzes extracellular nucleotides AMP, NAD & NMN) into membrane permeable nucleosides.D...

      • A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS13) in CVD II panel - Q76LX8

        ADAM-TS 13 (also known as von Willebrand factor-cleaving protease, VWFCP) is a is a zinc-containing metalloprotease that cleaves vWF multimers in plasma and so controls vWF-medi...

      • A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) in Oncology panel - Q8TE58

        ADAM-TS 15 is a member of the ADAM (a disintegrin and metalloproteinase) family of type I transmembrane glycoproteins, which are involved in cell adhesion and proteolytic ectodo...

      • Adenosine Deaminase (ADA) in Inflammation panel - P00813

        ADA is a key enzyme of the purine metabolism and it is involved in the breakdown of adenosine into nucleic acids. In humans it is primarily involved in the development and maint...

      • Adenosine Deaminase (ADA) in Immuno-Oncology panel - P00813

        ADA is a key enzyme of the purine metabolism and it is involved in the breakdown of adenosine into nucleic acids. In humans it is primarily involved in the development and maint...

      • Adenosylhomocysteinase (AHCY) in Metabolism Panel - P23526

        Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the co...

      • Adhesion G protein-coupled receptor E2 (ADGRE2) in Metabolism Panel - Q9UHX3

        Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and a...

      • Adhesion G-protein coupled receptor G1 (ADGRG1) in Immuno-Oncology panel - Q9Y653

        Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collage...

      • Adhesion G-protein coupled receptor G1 (ADGRG1) in Organ Damage Panel - Q9Y653

        Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collage...

      • Adhesion G-protein coupled receptor G2 (ADGRG2) in Metabolism Panel - Q8IZP9

        Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis.

      • ADM (ADM) in CVD II panel - P35318

        Adrenomedullin is cleaved into two peptides; adrenomedullin (AM) and proadrenomedullin N-20 peptide (PAMP). AM and PAMP are potent hypotensive and vasodilatator agents. Both pep...

      • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) in Neurology panel - P28907

        ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (also known as CD38) regulates the release of oxytocin within the central nervous system. The protein is expressed at high leve...

      • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1) in Development Panel - Q10588

        Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular s...

      • ADP-sugar pyrophosphatase (NUDT5) in Development Panel - Q9UKK9

        Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of...

      • Aggrecan core protein (ACAN) in Development Panel - P16112

        This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly ...

      • Agouti-related protein (AGRP) in CVD II panel - O00253

        Agouti-related protein also called Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron.

      • Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) in Organ Damage Panel - P30838

        ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitt...

      • Allergin-1 (MILR1) in Immune Response Panel - Q7Z6M3

        Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I imme...

      • Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) in Neurology panel - P30533

        Alpha-2-macroglobulin receptor-associated protein (also known as LDL-receptor-related protein-associated protein) is a glycoprotein that functions as a chaperone molecule.It is ...

      • Alpha-L-iduronidase (IDUA) in CVD II panel - P35475

        IDUA is an enzyme found in the lysosomes of cells, which catalyses the hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.

      • Alpha-taxilin (TXLNA) in Oncology panel - P40222

        Alpha-taxilin (also known as interleukin-14) is a cytokine involved in regulating the proliferation of normal and cancerous B cells. As well as inducing B-cell proliferation, th...

      • Aminopeptidase N (AP-N) in CVD III panel - P15144

        AP-N is a broad specificity aminopeptidase. It may play a critical role in the pathogenesis of cholesterol gallstone disease, and may be involved in the metabolism of regulatory...

      • Amphiregulin (AREG) in Oncology panel - P15514

        Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

      • Amphiregulin (AREG) in Immune Response Panel - P15514

        Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

      • Amphoterin-induced protein 2 (AMIGO2) in Cell Regulation Panel - Q86SJ2

        Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3...

      • Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP) in Cell Regulation Panel - Q7Z5R6

        Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates...

      • Amyloid beta A4 protein (APP) in Development Panel - P05067

        Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in c...

      • Amyloid-like protein 1 (APLP1) in Metabolism Panel - P51693

        May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarit...

      • Angiogenin (ANG) in Cardiometabolic Panel - P03950

        Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that cont...

      • Angiopoietin-1 (ANG-1) in CVD II panel - Q15389

        ANG-1 is a member of the vascular growth factor family, and via its interactions with the TEK/TIE2 receptor, plays an important role in the regulation of angiogenesis.During emb...

      • Angiopoietin-1 (ANG-1) in Immuno-Oncology panel - Q15389

        ANG-1 is a member of the vascular growth factor family, and via its interactions with the TEK/TIE2 receptor, plays an important role in the regulation of angiogenesis.During emb...

      • Angiopoietin-1 receptor (TIE2) in CVD II panel - Q02763

        Angiopoietin/Tie receptor signaling cascades are involved in fundamental angiogenesis events including vascular stabilization and remodeling, as well as recruitment of pericytes...

      • Angiopoietin-1 receptor (TIE2) in Immuno-Oncology panel - Q02763

        Angiopoietin/Tie receptor signaling cascades are involved in fundamental angiogenesis events including vascular stabilization and remodeling, as well as recruitment of pericytes...

      • Angiopoietin-2 (ANGPT2) in Immuno-Oncology panel - O15123

        Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absen...

      • Angiopoietin-2 (ANGPT2) in Metabolism Panel - O15123

        Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absen...

      • Angiopoietin-related protein 1 (ANGPTL1) in Metabolism Panel - O95841

        Angiopoietin-related protein 1 is a protein encoded by the ANGPTL1 gene.

      • Angiopoietin-related protein 3 (ANGPTL3) in Cardiometabolic Panel - Q9Y5C1

        Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to pla...

      • Angiopoietin-related protein 4 (ANGPTL4) in Development Panel - Q9BY76

        Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule fo...

      • Angiopoietin-related protein 7 (ANGPTL7) in Metabolism Panel - O43827

        Angiopoietin-related protein 7 is a protein encoded by the ANGPTL7 gene

      • Angiotensin-converting enzyme 2 (ACE2) in CVD II panel - Q9BYF1

        ACE2 is a carboxypeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin 1-9, or the conversion of angiotensin II to the vasodilator peptide angi...

      • Annexin A1 (ANXA1) in Oncology panel - P04083

        Annexin A1 belongs to a family of calcium-dependent phospholipid-binding proteins,and has roles in membrane fusion and exocytosis. It is principally located on the cytosolic fa...

      • Annexin A11 (ANXA11) in Metabolism Panel - P50995

        Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

      • Annexin A4 (ANXA4) in Metabolism Panel - P09525

        Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.

      • Anterior gradient protein 2 homolog (AGR2) in Organ Damage Panel - O95994

        Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a ro...

      • Anterior gradient protein 3 (AGR3) in Cell Regulation Panel - Q8TD06

        Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in trach...

      • Apolipoprotein M (APOM) in Cardiometabolic Panel - O95445

        Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.

      • Apoptosis-inducing factor 1, mitochondrial (AIFM1) in Organ Damage Panel - O95831

        Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol...

      • Appetite-regulating hormone (GHRL) in Metabolism Panel - Q9UBU3

        Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induc...

      • Arginase-1 (ARG1) in Immuno-Oncology panel - P05089

        Arginase-1 is a protein encoded by the ARG1 gene.

      • Arginase-1 (ARG1) in Metabolism Panel - P05089

        Arginase-1 is a protein encoded by the ARG1 gene.

      • Aromatic-L-amino-acid decarboxylase (DDC) in Metabolism Panel - P20711

        Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

      • Artemin (ARTN) in Inflammation panel - Q5T4W7

        Artermin is a neurotrophic factor from the GDNF family of ligands inside the TGF beta superfamily. Artemin is a suitable protein for performing exploratory analysis for the disc...

      • Aryl hydrocarbon receptor nuclear translocator (ARNT) in Immune Response Panel - P27540

        Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. T...

      • Arylsulfatase A (ARSA) in Development Panel - P15289

        Hydrolyzes cerebroside sulfate.

      • Arylsulfatase B (ARSB) in Cell Regulation Panel - P15848

        Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion...

      • ATP-dependent 6-phosphofructokinase, muscle type (PFKM) in Cell Regulation Panel - P08237

        Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

      • Axin-1 (AXIN1) in Inflammation panel - O15169

        Axin-1 is a protein that functions as a negative regulator in the Wnt signaling pathway. Axin-1 is a suitable protein for performing exploratory analysis for the discovery of ne...

      • Azurocidin (AZU1 in CVD III panel - P20160

        Azurocidin has a chemotactic and antibacterial activity and is also an important inflammatory mediator. It is a member of the serine protease gene family but it is not a serine ...

      • B-cell antigen receptor complex-associated protein beta chain (CD79B) in Metabolism Panel - P40259

        Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the...

      • B-cell scaffold protein with ankyrin repeats (BANK1) in Organ Damage Panel - Q8NDB2

        Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.

      • Baculoviral IAP repeat-containing protein 2 (BIRC2) in Immune Response Panel - Q13490

        Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferat...

      • Basal cell adhesion molecule (BCAM) in Development Panel - P50895

        Laminin alpha-5 receptor. May mediate intracellular signaling.

      • Bcl-2-like protein 11 isoform BimL (BCL2L11) in Cell Regulation Panel - O43521-2

        Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less pote...

      • BDNF/NT-3 growth factors receptor (NTRK2) in Neurology panel - Q16620

        BDNF/NT-3 growth factors receptor, NTRK2 (also known as tropomyosin-related kinase B), a membrane-bound receptor and member of the neurotrophic tyrosine receptor kinase (NTRK) f...

      • Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) in Cell Regulation Panel - Q02742

        Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core...

      • Beta-1,4-galactosyltransferase 1 (B4GALT1) in Development Panel - P15291

        The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharid...

      • Beta-1,4-glucuronyltransferase 1 (B4GAT1) in Development Panel - O43505

        Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the g...

      • Beta-Ala-His dipeptidase (CNDP1) in Cardiometabolic Panel - Q96KN2

        No functional description currently available for this protein.

      • Beta-galactosidase (GLB1) in Immune Response Panel - P16278

        Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays func...

      • Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1) in Cardiometabolic Panel - P15907

        Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

      • Beta-glucuronidase (GUSB) in Development Panel - P08236

        Plays an important role in the degradation of dermatan and keratan sulfates.

      • Beta-microseminoprotein (MSMB) in Development Panel - P08118

        No functional description currently available for this protein.

      • Beta-nerve growth factor (Beta-NGF) in Neurology panel - P01138

        Beta-NGF is a neurotrophic factor with an important role in neuron survival and it has been studied in various neurological disease conditions. Beta-NGF plays also a role as a s...

      • Beta-nerve growth factor (Beta-NGF) in Inflammation panel - P01138

        Beta-NGF is a neurotrophic factor with an important role in neuron survival and it has been studied in various neurological disease conditions. Beta-NGF plays also a role as a s...

      • BH3-interacting domain death agonist (BID) in Organ Damage Panel - P55957

        The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 d...

      • Biglycan (BGN) in Cell Regulation Panel - P21810

        May be involved in collagen fiber assembly.

      • Bile salt sulfotransferase (SULT2A1) in Cell Regulation Panel - Q06520

        Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.

      • Bleomycin hydrolase (BLM hydrolase) in CVD III panel - Q13867

        The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of it...

      • BMP and activin membrane-bound inhibitor homolog (BAMBI) in Organ Damage Panel - Q13145

        Negatively regulates TGF-beta signaling.

      • Bone morphogenetic protein 4 (BMP-4) in Neurology panel - P12644

        Bone morphogenetic protein 4 (also known as bone morphogenetic protein 2B) is a polypeptide belonging to the TGF-? superfamily of proteins. Its principle role is in cartilage an...

      • Bone morphogenetic protein 6 (BMP-6) in CVD II panel - P22004

        BMP-6 is a secreted signaling protein and a member of the transforming growth factor-beta (TGFB) superfamily. As one of several bone morphogenic proteins, it can induce ectopic ...

      • Brain-derived neurotrophic factor (BDNF) in Neurology panel - P23560

        BDNF is a neurotrophic factor and a myokine which has been studied in various neurological and metabolic disease conditions. BDNF is also produced by inflammatory cells and has ...

      • Brain-derived neurotrophic factor (BDNF) in Inflammation panel - P23560

        BDNF is a neurotrophic factor and a myokine which has been studied in various neurological and metabolic disease conditions. BDNF is also produced by inflammatory cells and has ...

      • Breakpoint cluster region protein (BCR) in Cell Regulation Panel - P11274

        GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

      • Brevican core protein (BCAN) in Neurology panel - Q96GW7

        Brevican core protein (also known as Brain-enriched hyaluronan-binding protein) is a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expr...

      • Brorin (VWC2) in Neurology panel - Q2TAL6

        Brorin (also known as von Willebrand factor C domain-containing protein 2) is a secreted bone morphogenic protein antagonist. It is suggested to play a role in neural developmen...

      • Brother of CDO (BOC) in CVD II panel - Q9BWV1

        Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

      • Brother of CDO (BOC) in Cell Regulation Panel - Q9BWV1

        Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

      • Butyrophilin subfamily 3 member A2 (BTN3A2) in Immune Response Panel - P78410

        Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.

      • C-C motif chemokine 14 (CCL14) in Cardiometabolic Panel - Q16627

        Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at ...

      • C-C motif chemokine 15 (CCL15) in CVD III panel - Q16663

        C-C motif chemokine 15 is a chemotactic factor attracting leukocytes

      • C-C motif chemokine 16 (CCL16) in CVD III panel - O15467

        CCL16 is a chemokine that is expressed by the?liver,?thymus, and?spleen?and is chemoattractive for?monocytes?and?lymphocytes, but not neutrophils. Cellular expression of this pr...

      • C-C motif chemokine 17 (CCL17) in CVD II panel - Q92583

        CCL17 (also known as thymus and activation regulated chemokine, TARC) is s a small cytokine belonging to the CC chemokine family. The protein is expressed constitutively in thym...

      • C-C motif chemokine 17 (CCL17) in Immuno-Oncology panel - Q92583

        CCL17 (also known as thymus and activation regulated chemokine, TARC) is s a small cytokine belonging to the CC chemokine family. The protein is expressed constitutively in thym...

      • C-C motif chemokine 18 (CCL18) in Cardiometabolic Panel - P55774

        Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lympho...

      • C-C motif chemokine 19 (CCL19) in Inflammation panel - Q99731

        CCL19 is a chemokine that upon binding to its receptors CCR10 and CCR7 may play a role in normal lymphocyte recirculation and homing as well as in inflammatory and immunological...

      • C-C motif chemokine 19 (CCL19) in Immuno-Oncology panel - Q99731

        CCL19 is a chemokine that upon binding to its receptors CCR10 and CCR7 may play a role in normal lymphocyte recirculation and homing as well as in inflammatory and immunological...

      • C-C motif chemokine 20 (CCL20) in Inflammation panel - P78556

        CCL20 is a chemokine involved in chemotaxis and inflammatory response. Experimental results in animal models of multiple sclerosis suggest that CCL20 may play a critical role in...

      • C-C motif chemokine 20 (CCL20) in Immuno-Oncology panel - P78556

        CCL20 is a chemokine involved in chemotaxis and inflammatory response. Experimental results in animal models of multiple sclerosis suggest that CCL20 may play a critical role in...

      • C-C motif chemokine 21 (CCL21) in Development Panel - O00585

        Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential a...

      • C-C motif chemokine 22 (CCL22) in CVD III panel - O00626

        The?CCL22 protein is secreted by dendritic cells and?macrophages, and elicits its effects on its target cells by interacting with cell surface?chemokine receptors?such as?CCR4. ...

      • C-C motif chemokine 23 (CCL23) in Inflammation panel - P55773

        CCL23 is a chemokine with highly chemotactic activity for resting T cells and monocytes. CCL23 has been described to be involved in several inflammation-related diseases such as...

      • C-C motif chemokine 23 (CCL23) in Immuno-Oncology panel - P55773

        CCL23 is a chemokine with highly chemotactic activity for resting T cells and monocytes. CCL23 has been described to be involved in several inflammation-related diseases such as...

      • C-C motif chemokine 24 (CCL24) in CVD III panel - O00175

        CCL24 is a small?cytokine?that interacts with?chemokine receptor?CCR3?to induce?chemotaxis?in?eosinophils. This chemokine is also strongly chemotactic for resting T?lymphocytes?...

      • C-C motif chemokine 25 (CCL25) in Inflammation panel - O15444

        CCL25 is a chemokine that upon binding to its receptor CCR9 is involved in chemotaxis and inflammatory response. CCL25 is highly expressed in the thymus and small intestine and ...

      • C-C motif chemokine 28 (CCL28) in Inflammation panel - Q9NRJ3

        CCL28 is a chemokine that upon binding to its receptors CCR10 and CCR3 exerts its chemotactic activity on T and B cells, and eosinophils and together they play an important role...

      • C-C motif chemokine 3 (CCL3) in CVD II panel - P10147

        CCL3, also known as Macrophage inflammatory protein-1? (MIP-1?), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recru...

      • C-C motif chemokine 3 (CCL3) in Inflammation panel - P10147

        CCL3, also known as Macrophage inflammatory protein-1? (MIP-1?), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recru...

      • C-C motif chemokine 3 (CCL3) in Immuno-Oncology panel - P10147

        CCL3, also known as Macrophage inflammatory protein-1? (MIP-1?), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recru...

      • C-C motif chemokine 4 (CCL4 ) in Inflammation panel - P13236

        CCL4 (MIP 1-beta) is a chemokine that upon binding to its receptor CCR5 is involved in chemotaxis and inflammatory response, and it is one of the major HIV-suppressive factors p...

      • C-C motif chemokine 4 (CCL4 ) in Immuno-Oncology panel - P13236

        CCL4 (MIP 1-beta) is a chemokine that upon binding to its receptor CCR5 is involved in chemotaxis and inflammatory response, and it is one of the major HIV-suppressive factors p...

      • C-C motif chemokine 5 (CCL5) in Cardiometabolic Panel - P13501

        Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemok...

      • C-type lectin domain family 1 member A (CLEC1A) in Organ Damage Panel - Q8NC01

        C-type lectin domain family 1 member A is a protein encoded by the CLEC1A gene.

      • C-type lectin domain family 1 member B (CLEC1B) in Neurology panel - Q9P126

        C-type lectin domain family 1 member B (CLEC1B) is type II membrane receptor expressed in myeloid cells and NK cells. It is believed to have roles in platelet activation and lym...

      • C-type lectin domain family 10 member A (CLEC10A) in Neurology panel - Q8IUN9

        C-type lectin domain family 10 member A (also known as CD301) is a membrane-associated carbohydrate-binding protein and member of the C-type lectin/C-type lectin-like domain sup...

      • C-type lectin domain family 11 member A (CLEC11A) in Development Panel - Q9Y240

        Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts ...

      • C-type lectin domain family 14 member A (CLEC14A) in Development Panel - Q86T13

        No functional description currently available for this protein.

      • C-type lectin domain family 4 member A (CLEC4A) in Immune Response Panel - Q9UMR7

        May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immuno...

      • C-type lectin domain family 4 member C (CLEC4C) in Immune Response Panel - Q8WTT0

        Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of ...

      • C-type lectin domain family 4 member D (CLEC4D) in Immune Response Panel - Q8WXI8

        Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation t...

      • C-type lectin domain family 4 member G (CLEC4G) in Immune Response Panel - Q6UXB4

        Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. (Microbial infection) Acts as a receptor for Japanese encephal...

      • C-type lectin domain family 4 member K (CD207) in Oncology panel - Q9UJ71

        C-type lectin domain family 4 member K (CD207), also known as Langerin, is a type II transmembrane, C-type lectin receptor expressed in the immature dendritic cells of the epide...

      • C-type lectin domain family 5 member A (CLEC5A) in Metabolism Panel - Q9NY25

        Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial inj...

      • C-type lectin domain family 6 member A (CLEC6A) in Immune Response Panel - Q6EIG7

        Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C...

      • C-type lectin domain family 7 member A (CLEC7A) in Immune Response Panel - Q9BXN2

        Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary ...

      • C-type mannose receptor 2 (MRC2) in Cell Regulation Panel - Q9UBG0

        May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an end...

      • C-type natriuretic peptide (NPPC) in Organ Damage Panel - P23582

        Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive a...

      • C-X-C motif chemokine 1 (CXCL1) in CVD II panel - P09341

        CXCL1 is a chemokine that upon binding to its receptor CXCR2 elicits chemotactic activity on neutrophils and among others is involved in inflammatory response. CXCL1 has been de...

      • C-X-C motif chemokine 1 (CXCL1) in Inflammation panel - P09341

        CXCL1 is a chemokine that upon binding to its receptor CXCR2 elicits chemotactic activity on neutrophils and among others is involved in inflammatory response. CXCL1 has been de...

      • C-X-C motif chemokine 1 (CXCL1) in Immuno-Oncology panel - P09341

        CXCL1 is a chemokine that upon binding to its receptor CXCR2 elicits chemotactic activity on neutrophils and among others is involved in inflammatory response. CXCL1 has been de...

      • C-X-C motif chemokine 10 (CXCL10 ) in Inflammation panel - P02778

        CXCL10 (IP-10) is a chemokine that upon binding to its receptor CXCR3 elicits its chemotactic activity on monocytes, T cells, NK cells, and dendritic cells. IP-10 is not constit...

      • C-X-C motif chemokine 10 (CXCL10 ) in Immuno-Oncology panel - P02778

        CXCL10 (IP-10) is a chemokine that upon binding to its receptor CXCR3 elicits its chemotactic activity on monocytes, T cells, NK cells, and dendritic cells. IP-10 is not constit...

      • C-X-C motif chemokine 11 (CXCL11) in Inflammation panel - O14625

        CXCL11 is a chemokine that upon binding to its receptor CXCR3 elicits chemotactic activity on interleukin-activated T cells and it is also involved in inflammatory response. CXC...

      • C-X-C motif chemokine 11 (CXCL11) in Immuno-Oncology panel - O14625

        CXCL11 is a chemokine that upon binding to its receptor CXCR3 elicits chemotactic activity on interleukin-activated T cells and it is also involved in inflammatory response. CXC...

      • C-X-C motif chemokine 13 (CXCL13 ) in Oncology panel - O43927

        C-X-C motif chemokine 13 (CXCL13) also known as B lymphocyte chemoattractant (BLC), is a small cytokine belonging to the CXC chemokine family. CXCL13 and its receptor CXCR5 cont...

      • C-X-C motif chemokine 13 (CXCL13 ) in Immuno-Oncology panel - O43927

        C-X-C motif chemokine 13 (CXCL13) also known as B lymphocyte chemoattractant (BLC), is a small cytokine belonging to the CXC chemokine family. CXCL13 and its receptor CXCR5 cont...

      • C-X-C motif chemokine 16 (CXCL16) in CVD III panel - Q9H2A7

        C-X-C motif chemokine 16 acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in...

      • C-X-C motif chemokine 5 (CXCL5 ) in Inflammation panel - P42830

        CXCL5 is a chemokine that upon binding to its receptor CXCR2 elicits chemotactic activity on neutrophils. It is activated upon interleukin-1 and TNF-alpha stimulation. CXCL5 has...

      • C-X-C motif chemokine 5 (CXCL5 ) in Immuno-Oncology panel - P42830

        CXCL5 is a chemokine that upon binding to its receptor CXCR2 elicits chemotactic activity on neutrophils. It is activated upon interleukin-1 and TNF-alpha stimulation. CXCL5 has...

      • C-X-C motif chemokine 6 (CXCL6) in Inflammation panel - P80162

        CXCL6 is a chemokine that upon binding to its receptors CXCR1 and CXCR2 elicits chemotactic activity on neutrophilic granulocytes. CXCL6 has been described to be involved in inf...

      • C-X-C motif chemokine 9 (CXCL9 ) in Inflammation panel - Q07325

        CXCL9 (MIG) is a chemokine that upon binding to its receptor CXCR3 elicits chemotactic activity on T cells and is involved in inflammatory response. CXCL9 is not constitutively ...

      • C-X-C motif chemokine 9 (CXCL9 ) in Immuno-Oncology panel - Q07325

        CXCL9 (MIG) is a chemokine that upon binding to its receptor CXCR3 elicits chemotactic activity on T cells and is involved in inflammatory response. CXCL9 is not constitutively ...

      • Cadherin-1 (CDH1) in Cardiometabolic Panel - P12830

        Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to...

      • Cadherin-2 (CDH2) in Metabolism Panel - P19022

        Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to...

      • Cadherin-3 (CDH3) in Neurology panel - P22223

        Cadherin-3 (also known as placental cadherin) is a calcium-dependent cell-cell adhesion glycoprotein, which like other members of the cadherin superfamily achieves cellular conn...

      • Cadherin-5 (CDH5) in CVD III panel - P33151

        Cadherin-5 is a calcium-dependent cell adhesion protein. It may play an important role in enothelial cell biology through control and organization of intercellular junctions.

      • Cadherin-6 (CDH6) in Neurology panel - P55285

        Cadherin-6 (also known as Kidney cadherin) is a calcium-dependent cell adhesion protein. Like other members of the the cadherin family, CADH6 mediates cell-cell binding in a hom...

      • Cadherin-related family member 5 (CDHR5) in Metabolism Panel - Q9HBB8

        Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the pa...

      • Calcitonin (CALCA) in Organ Damage Panel - P01258

        Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Katacalcin is a potent p...

      • Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) in Cell Regulation Panel - Q8N5S9

        Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK...

      • Calreticulin (CALR) in Organ Damage Panel - P27797

        Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin inter...

      • Calsyntenin-2 (CLSTN2) in Metabolism Panel - Q9H4D0

        May modulate calcium-mediated postsynaptic signals.

      • Calsyntenin-3 (CLSTN3) in Cell Regulation Panel - Q9BQT9

        May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secreti...

      • Carbonic anhydrase 1 (CA1) in Cardiometabolic Panel - P00915

        Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.

      • Carbonic anhydrase 12 (CA12) in Organ Damage Panel - O43570

        Reversible hydration of carbon dioxide.

      • Carbonic anhydrase 13 (CA13) in Metabolism Panel - Q8N1Q1

        Reversible hydration of carbon dioxide.

      • Carbonic anhydrase 14 (CA14) in Organ Damage Panel - Q9ULX7

        Reversible hydration of carbon dioxide.

      • Carbonic anhydrase 2 (CA2) in Development Panel - P00918

        Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation o...

      • Carbonic anhydrase 3 (CA3) in Cardiometabolic Panel - P07451

        Reversible hydration of carbon dioxide.

      • Carbonic anhydrase 4 (CA4) in Cardiometabolic Panel - P22748

        Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload remova...

      • Carbonic anhydrase 5A, mitochondrial (CA5A) in CVD II panel - P35218

        CA5A is a zince-dependent mitochondrial enzyme involved in the reversible hydration of carbon dioxide. Mutations in the CA5A gene can result in hyperammonemia, an autosomal rece...

      • Carbonic anhydrase 6 (CA6) in Development Panel - P23280

        Reversible hydration of carbon dioxide. Its role in saliva is unknown.

      • Carbonic anhydrase IX (CAIX) in Oncology panel - Q16790

        CA9 is considered to be one of the best cellular biomarkers of hypoxia. Furthermore, recent studies examining the association between CA9 levels and various clinicopathological ...

      • Carbonic anhydrase IX (CAIX) in Immuno-Oncology panel - Q16790

        CA9 is considered to be one of the best cellular biomarkers of hypoxia. Furthermore, recent studies examining the association between CA9 levels and various clinicopathological ...

      • Carboxypeptidase A1 (CPA1) in CVD III panel - P15085

        Carboxypeptidase A1 is an enzyme involved in zymogen inhibition.

      • Carboxypeptidase A2 (CPA2) in Neurology panel - P48052

        Carboxypeptidase A2 is a member of the carboxypeptidase A family of enzymes, which employ a zinc ion within target proteins for hydrolysis of the peptide bond at the C-terminal ...

      • Carboxypeptidase B (CPB1) in CVD III panel - P15086

        Carboxypeptidase B is an enzyme involved in metabolizing the C5a protein into C5a des-Arg.

      • Carboxypeptidase E (CPE) in Oncology panel - P16870

        Carboxypeptidase E (also known as carboxypeptidase H, or convertase) is an exopeptidase that activates neuropeptides and peptide hormones, by cleaving off basic C-terminal amin...

      • Carboxypeptidase M (CPM) in Neurology panel - P14384

        Carboxypeptidase M is a membrane-bound arginine/lysine carboxypeptidase that is associated with monocyte to macrophage differentiation. It is believed to play important roles in...

      • Carcinoembryonic antigen (CEA) in Oncology panel - P06731

        Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. CEA measurement is mainly used as a tumor marker to identify recurrences after surgical resection, or...

      • Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in Oncology panel - P13688

        Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), also known as CD66a is a glycoprotein belonging to the immunoglobulin superfamily. CEACAM1 functions as a ce...

      • Carcinoembryonic antigenrelated cell adhesion molecule 8 (CEACAM8) in CVD II panel - P31997

        CEACAM8 (also known as Cluster of Differentiation 66b, CD66b) finctions in cell adhesion, cell migration, and pathogen binding. It is expressed exclusively on granulocytes and i...

      • Cartilage acidic protein 1 (CRTAC1) in Cardiometabolic Panel - Q9NQ79

        No functional description currently available for this protein.

      • Cartilage oligomeric matrix protein (COMP) in Cardiometabolic Panel - P49747

        May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the inte...

      • Casein kinase I isoform delta (CSNK1D) in Organ Damage Panel - P48730

        Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phospho...

      • Caspase-3 (CASP-3) in CVD III panel - P42574

        Caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with Caspase-8 and Caspase-9. CASP-3 plays an important role in cell apoptosis and is involved ...

      • Caspase-8 (CASP-8 ) in Inflammation panel - Q14790

        CASP-8 is a cysteine protease that functions as an activator of effector caspases and is involved in apoptosis. In the immune system it is also involved in activation of T, B, a...

      • Caspase-8 (CASP-8 ) in Immuno-Oncology panel - Q14790

        CASP-8 is a cysteine protease that functions as an activator of effector caspases and is involved in apoptosis. In the immune system it is also involved in activation of T, B, a...

      • Catechol O-methyltransferase (COMT) in Metabolism Panel - P21964

        Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroacti...

      • Cathepsin D (CTSD) in CVD III panel - P07339

        Cathepsin D is an acid protease active in intracellular protein breakdown and nvolved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer diseas...

      • Cathepsin F (CTSF) in Development Panel - Q9UBX1

        Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

      • Cathepsin L1 (CTSL1) in CVD II panel - P07711

        Cathepsin L has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to prot...

      • Cathepsin L2 (CTSV) in Oncology panel - O60911

        Cathepsin L2 (also known as cathepsin V) is a lysosomal cysteine proteinase and a member of the peptidase C1 family. It is thought to play an important role in corneal physiolog...

      • Cathepsin O (CTSO) in Metabolism Panel - P43234

        Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

      • Cathepsin S (CTSS) in Neurology panel - P25774

        Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Cathepsin S is expressed by antigen presenting cells and has a long-established role i...

      • Cathepsin Z (CTSZ) in CVD III panel - Q9UBR2

        Cathepsin Z is a lysosomal cysteine proteinase and member of the peptidase C1 family that exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities, representing a ...

      • Cation-independent mannose-6-phosphate receptor (IGF2R) in Development Panel - P11717

        Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to m...

      • CD109 antigen (CD109) in Development Panel - Q6YHK3

        Modulates negatively TGFB1 signaling in keratinocytes.

      • CD160 antigen (CD160) in Oncology panel - O95971

        CD160 antigen is a glycoprotein which functions as a receptor showing broad specificity for both classical and non-classical MHC class I molecules. It has also been investigated...

      • CD166 antigen (ALCAM) in CVD III panel - Q13740

        CD166 antigen is a cell adhesion molecule that binds to CD6. It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, a...

      • CD177 antigen (CD177) in Development Panel - Q8N6Q3

        No functional description currently available for this protein.

      • CD2-associated protein (CD2AP) in Metabolism Panel - Q9Y5K6

        Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory...

      • CD209 antigen (CD209) in Development Panel - Q9NNX6

        Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosi...

      • CD27 antigen (CD27) in Oncology panel - P26842

        CD27 antigen is a member of the tumor necrosis factor receptor superfamily, and is needed for generation and maintenance of T cell immunity. Via its interactions with ligand CD7...

      • CD27 antigen (CD27) in Immuno-Oncology panel - P26842

        CD27 antigen is a member of the tumor necrosis factor receptor superfamily, and is needed for generation and maintenance of T cell immunity. Via its interactions with ligand CD7...

      • CD40 ligand (CD40-L) in CVD II panel - P29965

        Soluble CD40 ligand (sCD40L) is contained in platelet granules and thus its presence in the blood is a marker of platelet activation. By interacting with CD40, which is found on...

      • CD40 ligand (CD40-L) in Immuno-Oncology panel - P29965

        Soluble CD40 ligand (sCD40L) is contained in platelet granules and thus its presence in the blood is a marker of platelet activation. By interacting with CD40, which is found on...

      • CD40L receptor (CD40) in Inflammation panel - P25942

        CD40 is a member of the TNF-receptor superfamily. It is found on antigen presenting cells where, upon binding of its ligand CD40L, it stimulates them and induces a broad variety...

      • CD40L receptor (CD40) in Immuno-Oncology panel - P25942

        CD40 is a member of the TNF-receptor superfamily. It is found on antigen presenting cells where, upon binding of its ligand CD40L, it stimulates them and induces a broad variety...

      • CD48 antigen (CD48) in Oncology panel - P09326

        CD48 antigen, also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a member of the CD2 subfamily of the immunoglobul...

      • CD59 glycoprotein (CD59) in Cardiometabolic Panel - P13987

        Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation ...

      • CD70 antigen (CD70) in Oncology panel - P32970

        CD70 antigen is expressed on highly activated lymphocytes, where it functions as a ligand for CD27. Due to its preferential expression in lymphomas compared to normal lymphocyte...

      • CD70 antigen (CD70) in Immuno-Oncology panel - P32970

        CD70 antigen is expressed on highly activated lymphocytes, where it functions as a ligand for CD27. Due to its preferential expression in lymphomas compared to normal lymphocyte...

      • CD83 antigen (CD83) in Immuno-Oncology panel - Q01151

        May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

      • CD83 antigen (CD83) in Immune Response Panel - Q01151

        May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.

      • CD97 antigen (CD97) in Development Panel - P48960

        Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).

      • CD99 antigen-like protein 2 (CD99L2) in Development Panel - Q8TCZ2

        Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By si...

      • Cell adhesion molecule 3 (CADM3) in Neurology panel - Q8N126

        Cell adhesion molecule 3 (also known as brain immunoglobulin receptor and nectin-like protein 1) is related to the nectin family of calcium-independent cell adhesion molecules. ...

      • Cell adhesion molecule-related/down-regulated by oncogenes (CDON) in Development Panel - Q4KMG0

        Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

      • Cell growth-regulating nucleolar protein (LYAR) in Cell Regulation Panel - Q9NX58

        No functional description currently available for this protein.

      • Cell surface glycoprotein CD200 receptor 1 (CD200R1) in Neurology panel - Q8TD46

        Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an inhibitory receptor for the myeloid cell regulatory protein, CD200/OX2. It limits inflammation by inhibiting the expre...

      • Cellular tumor antigen p53 (TP53) in Cell Regulation Panel - P04637

        Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation ...

      • Cerebral dopamine neurotrophic factor (CDNF) in Cell Regulation Panel - Q49AH0

        Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the...

      • Chitinase-3-like protein 1 (CHI3L1) in CVD III panel - P36222

        CHI3LI (also known as YKL-40) is a secreted glycoprotein related to the chitinases, but lacking chitin hydrolysis activity. It is able to promote angiogenesis through VEGF-depen...

      • Chitotriosidase-1 (CHIT1) in CVD III panel - Q13231

        Chitotriosidase is secreted by macrophages and involved in chitin catabolic processes and immune response.

      • Chordin-like protein 2 (CHRDL2) in Metabolism Panel - Q6WN34

        May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal c...

      • Chymotrypsin C (CTRC) in CVD II panel - Q99895

        CTRC (also known as Caldecrin) is a member of the peptidase S1 family of proteins. It regulates activation and degradation of trypsinogens and procarboxypeptidases,targeting spe...

      • Claspin (CLSPN) in Organ Damage Panel - Q9HAW4

        Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein whi...

      • Clusterin-like protein 1 (CLUL1) in Metabolism Panel - Q15846

        Clusterin-like protein 1 is a protein encoded by the CLUL1 gene

      • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1) in Organ Damage Panel - Q11201

        It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on cert...

      • CMRF35-like molecule 1 (CLM-1) in Neurology panel - Q8TDQ1

        CMRF35-like molecule 1 (CLM-1, also known as CD300f) is an inhibitory receptor of the Ig superfamily, and is expressed on myeloid cells. It mediates negative regulatory signals ...

      • CMRF35-like molecule 6 (CLM-6) in Neurology panel - Q08708

        CMRF35-like molecule 6 (also known as CD300c) is an antigen present on the surface of monocytes, neutrophils, and some T and B lymphocytes. It is believed to function as a recep...

      • CMRF35-like molecule 9 (CD300LG) in Development Panel - Q6UXG3

        Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

      • Coagulation factor VII (F7) in Cardiometabolic Panel - P08709

        Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor...

      • Coagulation factor XI (F11) in Cardiometabolic Panel - P03951

        Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

      • Cocaine esterase (CES2) in Organ Damage Panel - O00748

        Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl ...

      • Cochlin (COCH) in Development Panel - O43405

        Plays a role in the control of cell shape and motility in the trabecular meshwork.

      • Coiled-coil domain-containing protein 80 (CCDC80) in Metabolism Panel - Q76M96

        Promotes cell adhesion and matrix assembly.

      • Collagen alpha-1(I) chain (COL1A1) in CVD III panel - P02452

        Collagen alpha-1(I) chain is the major component of fibrillar collagen found in most connective tissues including cartilage.

      • Collagen alpha-1(IV) chain (COL4A1) in Cell Regulation Panel - P02462

        Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nid...

      • Collagen alpha-1(XVIII) chain (COL18A1) in Cardiometabolic Panel - P39060

        COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferatio...

      • Collectin-12 (COLEC12) in Development Panel - Q5KU26

        Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates t...

      • Complement C1q tumor necrosis factor-related protein 1 (C1QTNF1) in Cardiometabolic Panel - Q9BXJ1

        No functional description currently available for this protein.

      • Complement C2 (C2) in Cardiometabolic Panel - P06681

        Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then comb...

      • Complement component C1q receptor (CD93) in CVD III panel - Q9NPY3

        Complement component C1q receptor is a transmembrane receptor once thought to be a receptor for C1q, but is now thought to play a role in cell adhesion and phagocytosis in monoc...

      • Complement factor H-related protein 5 (CFHR5) in Cardiometabolic Panel - Q9BXR6

        Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH.

      • Complement receptor type 2 (CR2) in Cardiometabolic Panel - P20023

        Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. (Microbial infection) Acts as a re...

      • Cone-rod homeobox protein (CRX) in Cell Regulation Panel - O43186

        Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts ...

      • Contactin-1 (CNTN1) in CVD III panel - Q12860

        Contactin-1 is a?glycosylphosphatidylinositol-anchored?neuronal?membrane protein?that functions as a?cell adhesion?molecule. It may play a role in the formation of?axon?connecti...

      • Contactin-2 (CNTN2) in Organ Damage Panel - Q02246

        In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels...

      • Contactin-4 (CNTN4) in Development Panel - Q8IWV2

        Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.

      • Contactin-5 (CNTN5) in Neurology panel - O94779

        Contactin-5 (also known as Neural recognition molecule NB-2) is a member of the contactin family, which mediate cell surface interactions during nervous system development. CNTN...

      • Contactin-associated protein-like 2 (CNTNAP2) in Immune Response Panel - Q9UHC6

        May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparan...

      • Corneodesmosin (CDSN) in Immune Response Panel - Q15517

        Important for the epidermal barrier integrity.

      • Cornulin (CRNN) in Oncology panel - Q9UBG3

        Cornulin, also known as 53 kDa squamous epithelial-induced stress protein or 58 kDa heat shock protein, is a putative calcium-binding protein that has been demonstrated to funct...

      • Corticoliberin (CRH) in Organ Damage Panel - P06850

        Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (B...

      • Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1) in Immune Response Panel - P28845

        Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In i...