• Proseek Multiplex Development

    Casting a broader net to further explore the complexity of the human proteome

    Complementing and expanding on our previous portfolio of disease area-focused biomarker panels, our exploratory panels offers scientists the chance to cast a wider net in the quest to identify new biomarkers and relevant protein signatures, offering many new assays focused on important biological processes with wide-ranging clinical relevance.

    The Development panel offers simultaneous analysis of 92 protein biomarkers using just 1 µL of biological sample, and all assays are subject to Olink’s strict technical validation and QC control procedures. The selection of protein biomarker assays is designed to provide the optimal dynamic range, as well as to focus on proteins with relevance for developmental processes. Categorization of the proteins included in the panel was carried out via referral to widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET. The assays in this panel include proteins involved in key biological processes such as cell migration & motility, extracellular matrix organization and neurogenesis.

    An alphabetical list of the 92 proteins with links to the individual biomarker pages containing additional information and assay validation data can be found at the bottom of this page.

    An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data.

    Biological Process

    Disease Area

    Tissue Expression

    Protein Class

     

    Please Note: the Development panel uses a 1:100 dilution of sample, whereas our technical validation assays are performed in vitro using recombinant analytes. Technical validation data reported on the biomarker pages below, and in the data validation document for this panel are based on these in vitro assays. A multiplication factor of 100 should therefore be taken into consideration when comparing the addressable biological concentration to the in vitro validation data. You can download the Sample Dilution Guideline for this panel here.

    A comprehensive list of all protein biomarkers that can be measured using the currently available biomarker panels can be seen on the biomarker library page.

    Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>

    If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.

    The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.

  • Search all our biomarkers

      Biomarkers in Development

      • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (BST1)

        Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular s...

      • ADP-sugar pyrophosphatase (NUDT5)

        Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of...

      • Aggrecan core protein (ACAN)

        This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly ...

      • Amyloid beta A4 protein (APP)

        Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in c...

      • Angiopoietin-related protein 4 (ANGPTL4)

        Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule fo...

      • Arylsulfatase A (ARSA)

        Hydrolyzes cerebroside sulfate.

      • Basal cell adhesion molecule (BCAM)

        Laminin alpha-5 receptor. May mediate intracellular signaling.

      • Beta-1,4-galactosyltransferase 1 (B4GALT1)

        The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharid...

      • Beta-1,4-glucuronyltransferase 1 (B4GAT1)

        Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the g...

      • Beta-glucuronidase (GUSB)

        Plays an important role in the degradation of dermatan and keratan sulfates.

      • Beta-microseminoprotein (MSMB)

        No functional description currently available for this protein.

      • C-C motif chemokine 21 (CCL21)

        Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential a...

      • C-type lectin domain family 11 member A (CLEC11A)

        Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts ...

      • C-type lectin domain family 14 member A (CLEC14A)

        No functional description currently available for this protein.

      • Carbonic anhydrase 2 (CA2)

        Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation o...

      • Carbonic anhydrase 6 (CA6)

        Reversible hydration of carbon dioxide. Its role in saliva is unknown.

      • Cathepsin F (CTSF)

        Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

      • Cation-independent mannose-6-phosphate receptor (IGF2R)

        Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to m...

      • CD109 antigen (CD109)

        Modulates negatively TGFB1 signaling in keratinocytes.

      • CD177 antigen (CD177)

        No functional description currently available for this protein.

      • CD209 antigen (CD209)

        Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosi...

      • CD97 antigen (CD97)

        Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity).

      • CD99 antigen-like protein 2 (CD99L2)

        Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By si...

      • Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

        Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).

      • CMRF35-like molecule 9 (CD300LG)

        Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).

      • Cochlin (COCH)

        Plays a role in the control of cell shape and motility in the trabecular meshwork.

      • Collectin-12 (COLEC12)

        Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates t...

      • Contactin-4 (CNTN4)

        Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.

      • Corticotropin-releasing factor-binding protein (CRHBP)

        Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

      • Cystatin-M (CST6)

        Shows moderate inhibition of cathepsin B but is not active against cathepsin C.

      • Cysteine-rich motor neuron 1 protein (CRIM1)

        May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and mainten...

      • Cysteine-rich with EGF-like domain protein 2 (CRELD2)

        May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.

      • Cytosolic phospholipase A2 (PLA2G4A)

        Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation...

      • Desmocollin-2 (DSC2)

        Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epiderm...

      • Dickkopf-related protein 3 (DKK3)

        Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalizatio...

      • Dystroglycan (DAG1)

        The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelinatio...

      • Early activation antigen CD69 (CD69)

        Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

      • Endothelial cell-selective adhesion molecule (ESAM)

        Can mediate aggregation most likely through a homophilic molecular interaction.

      • Fc receptor-like protein 5 (FCRL5)

        May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal...

      • Flavin reductase NADPH (BLVRB)

        Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrrol...

      • Follistatin-related protein 3 (FSTL3)

        Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- a...

      • Galactoside 3(4)-L-fucosyltransferase,Alpha-(1,3)-fucosyltransferase 5 (FUT3/5)

        May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in bl...

      • Glycoprotein hormones alpha chain (CGA)

        No functional description currently available for this protein.

      • Glycoprotein Xg (XG)

        No functional description currently available for this protein.

      • Hepatitis A virus cellular receptor 2 (HAVCR2)

        Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest ...

      • HLA class II histocompatibility antigen gamma chain (CD74)

        Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing trans...

      • Inactive serine protease PAMR1 (PAMR1)

        May play a role in regeneration of skeletal muscle.

      • Inhibin beta C chain (INHBC)

        Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse f...

      • Integrin alpha-5 (ITGA5)

        Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is ...

      • Integrin beta-1 (ITGB1)

        Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydro...

      • Interleukin-13 receptor subunit alpha-1 (IL13RA1)

        Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytoki...

      • Kunitz-type protease inhibitor 1 (SPINT1)

        Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).

      • Kunitz-type protease inhibitor 2 (SPINT2)

        Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

      • Lactadherin (MFGE8)

        Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity)....

      • Laminin subunit alpha-4 (LAMA4)

        Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by int...

      • LDLR chaperone MESD (MESDC2)

        Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway...

      • Legumain (LGMN)

        Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein de...

      • Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)

        Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr...

      • Low affinity immunoglobulin epsilon Fc receptor (FCER2)

        Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-spec...

      • Lymphocyte function-associated antigen 3 (CD58)

        Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent i...

      • Macrophage migration inhibitory factor (MIF)

        Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulatin...

      • Matrilin-2 (MATN2)

        Involved in matrix assembly.

      • Myocilin (MYOC)

        Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, c...

      • Neurofascin (NFASC)

        Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.

      • Nidogen-2 (NID2)

        Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has ...

      • Osteomodulin (OMD)

        May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).

      • Paired immunoglobulin-like type 2 receptor alpha (PILRA)

        Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellu...

      • Peptidyl-prolyl cis-trans isomerase B (PPIB)

        PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

      • Phosphatidylethanolamine-binding protein 1 (PEBP1)

        Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsi...

      • Platelet endothelial aggregation receptor 1 (PEAR1)

        When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.

      • Platelet-derived growth factor receptor beta (PDGFRB)

        Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the reg...

      • Protein deglycase DJ-1 (PARK7)

        Protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cy...

      • Protein disulfide-isomerase (P4HB)

        This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bond...

      • Protein NOV homolog (NOV)

        Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078...

      • Receptor-type tyrosine-protein phosphatase F (PTPRF)

        Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase d...

      • Roundabout homolog 1 (ROBO1)

        Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural ...

      • Scavenger receptor class F member 1 (SCARF1)

        Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role ...

      • Secretoglobin family 3A member 1 (SCGB3A1)

        Potential growth inhibitory cytokine.

      • Semaphorin-7A (SEMA7A)

        Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, acti...

      • Serine protease HTRA2, mitochondrial (HTRA2)

        Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC p...

      • Serine protease inhibitor Kazal-type 1 (SPINK1)

        Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similar...

      • Serine protease inhibitor Kazal-type 5 (SPINK5)

        Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier f...

      • Signal-regulatory protein beta-1 (SIRPB1)

        Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of ty...

      • Stress-induced-phosphoprotein 1 (STIP1)

        Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).

      • Synaptosomal-associated protein 29 (SNAP29)

        SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes a...

      • Thymosin beta-10 (TMSB10)

        Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).

      • Tissue alpha-L-fucosidase (FUCA1)

        Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

      • Tripeptidyl-peptidase 1 (TPP1)

        Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced b...

      • Tumor necrosis factor receptor superfamily member 19L (RELT)

        Mediates activation of NF-kappa-B. May play a role in T-cell activation.

      • Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

        Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modul...

      • V-set and immunoglobulin domain-containing protein 4 (VSIG4)

        Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

      • WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (WFIKKN2)

        Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological acti...