• Proseek Multiplex Neurology I

    Towards a better understanding of neurological disease and personalized medicine

    Neu-PptNeurological diseases represent a massive and growing challenge for global healthcare, with more than one billion people worldwide estimated to suffer from the consequences of such disorders. The discovery of neurology-related protein biomarkers and identification of clinically relevant protein signatures may pave the way for better understanding and diagnosis of neurological disorders, and facilitate better targeted treatments.

    Proseek® Multiplex Neurology I96×96 is a high-throughput, multiplex immunoassay enabling analysis of 92 neurology-related protein biomarkers across 96 samples simultaneously. This high level of multiplexing is achieved without any compromise on data quality, thanks to our proprietary Proximity Extension Assay (PEA) technology

    The panel panel offers a mix of established markers related to neurobiological processes and neurological diseases (e.g. neural development, axon guidance, synaptic function, or specific conditions such as Alzheimer’s disease), as well as some more exploratory proteins with broader roles in processes such as cellular regulation, immunology, development and metabolism. This balanced selection provides an ideal basis for protein biomarker discovery in the neurology area. For optimal assay performance, each analyte in the panel has been assessed in terms of sample material, specificity, precision, sensitivity, dynamic range, matrix effects and interference. Of the 92 assays provided, 89 are new and unique to this panel, with just 3 biomarkers overlapping with other Proseek Multiplex products.

    An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class (based on widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET) can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data.

    Biological Process

    Disease Area

    Tissue Expression

    Protein Class

    A comprehensive list of all protein biomarkers that can be measured using the currently available Proseek Multiplex panels can be seen on the biomarker library page.

    Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>

    If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.

    The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.

  • Search all our biomarkers

      Biomarkers in Proseek Multiplex Neurology

      • ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)

        ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (also known as CD38) regulates the release of oxytocin within the central nervous system. The protein is expressed at high leve...

      • Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP)

        Alpha-2-macroglobulin receptor-associated protein (also known as LDL-receptor-related protein-associated protein) is a glycoprotein that functions as a chaperone molecule.It is ...

      • BDNF/NT-3 growth factors receptor (NTRK2)

        BDNF/NT-3 growth factors receptor, NTRK2 (also known as tropomyosin-related kinase B), a membrane-bound receptor and member of the neurotrophic tyrosine receptor kinase (NTRK) f...

      • Beta-nerve growth factor (Beta-NGF)

        Beta-NGF is a neurotrophic factor with an important role in neuron survival and it has been studied in various neurological disease conditions. Beta-NGF plays also a role as a s...

      • Bone morphogenetic protein 4 (BMP-4)

        Bone morphogenetic protein 4 (also known as bone morphogenetic protein 2B) is a polypeptide belonging to the TGF-? superfamily of proteins. Its principle role is in cartilage an...

      • Brain-derived neurotrophic factor (BDNF)

        BDNF is a neurotrophic factor and a myokine which has been studied in various neurological and metabolic disease conditions. BDNF is also produced by inflammatory cells and has ...

      • Brevican core protein (BCAN)

        Brevican core protein (also known as Brain-enriched hyaluronan-binding protein) is a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expr...

      • Brorin (VWC2)

        Brorin (also known as von Willebrand factor C domain-containing protein 2) is a secreted bone morphogenic protein antagonist. It is suggested to play a role in neural developmen...

      • C-type lectin domain family 1 member B (CLEC1B)

        C-type lectin domain family 1 member B (CLEC1B) is type II membrane receptor expressed in myeloid cells and NK cells. It is believed to have roles in platelet activation and lym...

      • C-type lectin domain family 10 member A (CLEC10A)

        C-type lectin domain family 10 member A (also known as CD301) is a membrane-associated carbohydrate-binding protein and member of the C-type lectin/C-type lectin-like domain sup...

      • Cadherin-3 (CDH3)

        Cadherin-3 (also known as placental cadherin) is a calcium-dependent cell-cell adhesion glycoprotein, which like other members of the cadherin superfamily achieves cellular conn...

      • Cadherin-6 (CDH6)

        Cadherin-6 (also known as Kidney cadherin) is a calcium-dependent cell adhesion protein. Like other members of the the cadherin family, CADH6 mediates cell-cell binding in a hom...

      • Carboxypeptidase A2 (CPA2)

        Carboxypeptidase A2 is a member of the carboxypeptidase A family of enzymes, which employ a zinc ion within target proteins for hydrolysis of the peptide bond at the C-terminal ...

      • Carboxypeptidase M (CPM)

        Carboxypeptidase M is a membrane-bound arginine/lysine carboxypeptidase that is associated with monocyte to macrophage differentiation. It is believed to play important roles in...

      • Cathepsin S (CTSS)

        Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Cathepsin S is expressed by antigen presenting cells and has a long-established role i...

      • Cell adhesion molecule 3 (CADM3)

        Cell adhesion molecule 3 (also known as brain immunoglobulin receptor and nectin-like protein 1) is related to the nectin family of calcium-independent cell adhesion molecules. ...

      • Cell surface glycoprotein CD200 receptor 1 (CD200R1)

        Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an inhibitory receptor for the myeloid cell regulatory protein, CD200/OX2. It limits inflammation by inhibiting the expre...

      • CMRF35-like molecule 1 (CLM-1)

        CMRF35-like molecule 1 (CLM-1, also known as CD300f) is an inhibitory receptor of the Ig superfamily, and is expressed on myeloid cells. It mediates negative regulatory signals ...

      • CMRF35-like molecule 6 (CLM-6)

        CMRF35-like molecule 6 (also known as CD300c) is an antigen present on the surface of monocytes, neutrophils, and some T and B lymphocytes. It is believed to function as a recep...

      • Contactin-5 (CNTN5)

        Contactin-5 (also known as Neural recognition molecule NB-2) is a member of the contactin family, which mediate cell surface interactions during nervous system development. CNTN...

      • Cytotoxic and regulatory T-cell molecule (CRTAM)

        Cytotoxic and regulatory T-cell molecule (also known as CD_antigen: CD355) is mainly expressed in cells of the immune system, but also in Purkinje neurons in cerebellum. CRTAM i...

      • Dickkopf-related protein 4 (Dkk-4)

        Dickkopf-related protein 4 (Dkk-4) is a secreted protein with two cysteine rich regions and is involved in embryonic development via inhibition of the Wnt signaling pathway. Dkk...

      • Dipeptidyl peptidase 1 (CTSC)

        Dipeptidyl peptidase 1 (also known as cathepsin C) is a lysosomal exo-cysteine protease belonging to the peptidase C1 family. In immune/inflammatory cells, this protein appears ...

      • Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22)

        Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) is a member of the ADAM family of membrane-anchored proteins. ADAM 22 is highly expressed in the brain, ...

      • Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23)

        Disintegrin and metalloproteinase domain-containing protein 23 (ADAM23) is a non-catalytic metalloprotease-like protein and member of the large ADAM protein family. ADAM23 is hi...

      • Draxin (DRAXIN)

        Draxin (also known as dorsal inhibitory axon guidance protein and neucrin) is a secreted glycoprotein that plays an important role in neural development, particularly for the sp...

      • Ephrin type-B receptor 6 (EPHB6)

        Ephrin type-B receptor 6 is a kinase-defective receptor for ephrin-B1 and ephrin-B2, and modulates cell adhesion and migration both positively and negatively following ephrin st...

      • Ephrin-A4 (EFNA4)

        Ephrin-A4 (also known as EPH-related receptor tyrosine kinase ligand 4) is a member of the ephrin family, which comprise the largest subfamily of receptor protein-tyrosine kinas...

      • Epithelial discoidin domain-containing receptor 1 (DDR1)

        Epithelial discoidin domain-containing receptor 1 (also known as CD167a) is a receptor tyrosine kinase belonging to a subfamily with homology to a region to the Dictyostelium di...

      • Ezrin (EZR)

        Ezrin (also known as cytovillin and villin-2) is a member of the ERM protein family and functions as a protein-tyrosine kinase substrate in microvilli. It is probably involved i...

      • Fc receptor-like protein 2 (FcRL2)

        Fc receptor-like protein 2, FCRL2 (also known as CD307b) is a member of the immunoglobulin receptor superfamily that may have an regulatory role in normal and neoplastic B cell ...

      • Galectin-8 (gal-8)

        Gal-8 (also known as prostate carcinoma tumor antigen 1) is a beta-galactoside-binding lectin that has been implicated in many functions, such as development, differentiation, c...

      • GDNF family receptor alpha-1 (GFR-alpha-1)

        GDNF family receptor alpha-1(also known as RET ligand 1 and TGF-beta-related neurotrophic factor receptor 1) is the functional receptor for glial cell-derived neurotropic factor...

      • GDNF family receptor alpha-3 (GDNFR-alpha-3)

        GDNF family receptor alpha-3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. it functions as a receptor for the gli...

      • Glial cell line-derived neurotrophic factor (GDNF)

        hGDNF is a neurotrophic factor that is involved in neuron survival and regeneration, and has been suggested for potential treatment of Parkinson?s disease. hGDNF has been descri...

      • Glypican-5 (GCP5)

        Glypican-5 is a cell surface heparan sulfate and a member of the glypican-related integral membrane proteoglycan family. This integral membrane proteoglycan contains a core prot...

      • Granulocyte Colony-Stimulating Factor (G-CSF)

        Granulocyte colony-stimulating factor, G-CSF (also known as pluripoietin) is a glycoprotein hormone that functions as a cytokine and induces granulocytes via stimulation of the ...

      • Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha)

        Granulocyte macrophage colony-stimulating factor receptor (also known as CD116) is a receptor for GMCSF, which stimulates the production of white blood cells. The activated rece...

      • Granzyme A (GZMA)

        Granzyme A (also known as Hanukkah factor) is a protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morpholo...

      • Growth/differentiation factor 8 (GDF-8)

        Growth/differentiation factor 8 (also known as myostatin) is a member of the TGF beta protein family. It acts as a myokine, that is secreted by myocytes and inhibits muscle cell...

      • Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)

        Hydroxyacylglutathione hydrolase, mitochondrial (also known as glyoxalase II) is a thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and...

      • Interleukin-12 subunit beta, Interleukin-12 subunit alpha (IL-12B, IL-12A)

        Interleukin-12 is a heterodimeric cytokine encoded by two separate genes, IL-12A and IL-12B. It is involved in the differentiation of naive T cells into Th1 cells, and also stim...

      • Interleukin-5 receptor subunit alpha (IL-5R-alpha)

        Interleukin-5 receptor subunit alpha (also known as CD125) is a subunit of the heterodimeric cytokine receptor for interleukin-5. Activation by IL-5 results in stimulation of B ...

      • Junctional adhesion molecule B (JAM-B)

        Junctional adhesion molecule B (also known as junctional adhesion molecule 2) is a type I membrane protein that localizes to the tight junctions of epithelial and endothelial ce...

      • Kynureninase (KYNU)

        Kynureninase (also known as L-kynurenine hydrolase) catalyzes the cleavage of L-kynurenine, which is an important metabolite of L-tryptophan. L-kynurenine and its breakdown prod...

      • Latexin (LXN)

        Latexin, LTX (also known as endogenous carboxypeptidase inhibitor) is the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. LTX acts as a potent inhibitor...

      • Layilin (LAYN)

        Layilin (LAYN) is a transmembrane protein with homology to C-type lectins, and functions as a receptor for the extracellular matrix glycosaminiglycan, hyaluronate. It has also b...

      • Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

        Leucine-rich repeat transmembrane protein FLRT2 is a member of the fibronectin leucine rich transmembrane protein family, which function in cell adhesion and/or receptor signall...

      • Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2)

        Leukocyte-associated immunoglobulin-like receptor 2 (also known as CD306) is a member of the immunoglobulin superfamily and contains an Ig-like C2-type domain. By analogy wih th...

      • Linker for activation of T-cells family member 1 (LAT)

        Linker for activation of T-cells family member 1 (also known as p36-38) is a transmembrane protein that is expressed in multiple cell-types within the immune system. It acts as ...

      • Lysosome membrane protein 2 (SCARB2)

        Lysosome membrane protein 2 (also known as CD36) is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Animal studies suggest th...

      • Macrophage scavenger receptor types I and II (MSR1)

        Macrophage scavenger receptor types I and II (also known as CD204) represent two isoforms produced by the MSR1 gene. These are membrane glycoproteins implicated in the pathologi...

      • MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1)

        MAM domain-containing glycosylphosphatidylinositol anchor protein 1, MDGA1 (also known as MAM domain-containing protein 3) is a membrane protein expressed in brain, heart, skele...

      • Matrilin-3 (MATN3)

        Matrilin-3 is a member of the von Willebrand factor A domain-containing protein family, and is expressed only in cartilaginous tissues.It is a major component of the extracellul...

      • Mesencephalic astrocyte-derived neurotrophic factor (MANF)

        Mesencephalic astrocyte-derived neurotrophic factor (also known as protein ARMET) selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulate...

      • N-acylethanolamine-hydrolyzing acid amidase (NAAA)

        N-acylethanolamine-hydrolyzing acid amidase (also known as acid ceramidase-like protein) degrades bioactive fatty acid amides to their corresponding acids. It plays an important...

      • Neprilysin (NEP)

        Neprilysin (also known as membrane metallo-endopeptidase, neutral endopeptidase, or CD10), is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydroph...

      • Netrin receptor UNC5C (UNC5C)

        Netrin receptor UNC5C (also known as protein unc-5 homolog C) belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell ...

      • Neuroblastoma suppressor of tumorigenicity 1 (NBL1)

        Neuroblastoma suppressor of tumorigenicity 1 (also known as DAN domain family member 1) is a member of the CAN (Cerberus and DAN) family of proteins, which contain a domain res...

      • Neurocan core protein (NCAN)

        Neurocan core protein (NCAN) is a chondroitin sulfate proteoglycan that is expessed specifically in the brain, and modulates neuronal adhesion and neurite growth during developm...

      • Neuronal cell adhesion molecule (Nr-CAM)

        Neuronal cell adhesion molecule (Nr-CAM) is ankyrin-binding protein that belongs to the immunoglobulin superfamily. Nr-CAM is essential for normal responses to cell-cell contact...

      • Neuropilin-2 (NRP2)

        Neuropilin-2 (also known as Vascular endothelial cell growth factor 165 receptor 2) is a member of the neuropilin family of receptor proteins. It functions as a high affinity re...

      • Neutral ceramidase (N-CDase)

        Neutral ceramidase, N-CDase (also known as N-acylsphingosine amidohydrolase 2 and non-lysosomal ceramidase) hydrolyzes the sphingolipid ceramide into sphingosine and free fatty ...

      • Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1)

        Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1) is an enzyme which catalyzes biosynthesis of the coenzyme NAD, which is central to many metabolic redox...

      • NKG2D ligand 2 (N2DL-2)

        NKG2D ligand 2, N2DL-2 (also known as UL16-binding protein 2) is a cell surface glycoprotein that is related to MHC class I molecules, although it lacks the typical alpha 3 doma...

      • NT-3 growth factor receptor (NTRK3)

        NT-3 growth factor receptor (also known as tropomyosin receptor kinase C ) is a tyrosine-protein kinase receptor that interacts with multiple substrates such as SHC1, PI-3 kinas...

      • OX-2 membrane glycoprotein (CD200)

        OX-2 membrane glycoprotein (also known as CD200) is a type-1 membrane glycoprotein that belongs to the immunoglobulin superfamily. Indirect evidence suggests that suggest that t...

      • Platelet-derived growth factor receptor alpha (PDGF-R-alpha)

        Platelet-derived growth factor receptor alpha is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. It plays an essential role in ...

      • Plexin-B1 (PLXNB1)

        Plexin-B1 (also known as semaphorin receptor SEP) is a type I membrane protein that is highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and li...

      • Plexin-B3 (PLXNB3)

        Plexin-B3 (PLXNB3) is a receptor for the semaphorin, SEMA5A, which plays an important role in axon guidance, invasive growth and cell migration. Via its interaction with SEMA5A,...

      • Poliovirus receptor (PVR)

        Poliovirus receptor (also known as CD155 and Nectin-like protein 5) is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. The normal cellular function for PV...

      • Protogenin (PRTG)

        Protogenin (also known as protein Shen-Dan) is a membrane protein and member of the immunoglobulin superfamily. It is considered to be primarily a developmental protein that may...

      • R-spondin-1 (RSPO1)

        R-spondin-1 is is a secreted protein that interacts with WNT4 and is vital for the process of female sex development. Recently, R-Spondin 1 expression was reported to be elevate...

      • Repulsive guidance molecule A (RGMA)

        Repulsive guidance molecule A (RGMA) belongs to a family of glycosylphosphatidylinositol-linked cell-membrane-associated proteins that perform several functions in the developin...

      • RGM domain family member B (RGMB)

        RGM domain family member B (RGMB) is a glycosylphosphatidylinositol-anchored member of the repulsive guidance molecule family. The main role of this protein is presumed to be in...

      • Roundabout homolog 2 (ROBO2)

        Roundabout homolog 2 (ROBO2) is a member of the large immunoglobulin superfamily of proteins and functions as a receptor for SLIT2, playing a significant role in neural developm...

      • Scavenger receptor class A member 5 (SCARA5)

        Scavenger receptor class A member 5 (SCARA5) is a glycosylated membrane receptor for the the blood-iron homeostasis regulating protein, ferritin. SCARA5 mediates cellular uptake...

      • Scavenger receptor class F member 2 (SCARF2)

        Scavenger receptor class F member 2 (SCARF2) is a single-pass type I membrane protein that belongs to the scavenger family of proteins. It may function as a cellular adhesion p...

      • Secreted frizzled-related protein 3 (sFRP-3)

        Secreted frizzled-related protein 3 (sFRP-3) is an extracellular plasma membrane protein that is expressed in chondrocytes during embryonic development, and functions as an anta...

      • Serine/threonine-protein kinase receptor R3 (SKR3)

        Serine/threonine-protein kinase receptor R3 (also known as activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It is an im...

      • Sialic acid-binding Ig-like lectin 9 (Siglec-9)

        Sialic acid-binding Ig-like lectin 9, Siglec-9 (also known as CD329) is a carbohydrate-binding type I membrane protein that preferentially binds to alpha-2,3- or alpha-2,6-linke...

      • Sialoadhesin (SIGLEC1)

        Sialoadhesin, SIGLEC1 (also known as CD169) is a lectin found on the surface of macrophages that predominantly binds neutrophils, but also other immune system cell-types, by in...

      • SPARC-related modular calcium-binding protein 2 (SMOC2)

        SPARC-related modular calcium-binding protein 2, SMOC2 (also known as smooth muscle-associated protein 2) is part of the SPARC family of proteins, whose members are highly expre...

      • Sphingomyelin phosphodiesterase (SMPD1)

        Sphingomyelin phosphodiesterase (also known as acid sphingomyelinase) belongs to the sphingomyelin phosphodiesterase family. This enzyme converts sphingomyelin to ceramide and h...

      • Tenascin-R (TN-R)

        Tenascin-R (TN-R, also known as janus and restrictin) is an extracellular matrix protein expressed primarily in the central nervous system. It interactions with different cells ...

      • Testican-1 (SPOCK1)

        Testican-1 (also known as protein SPOCK) forms the protein core of a plasma proteoglycan that is related to glycoproteins such as SPARC. Its similarity to thyropin-type cysteine...

      • Thy-1 membrane glycoprotein (THY 1)

        Thy-1 membrane glycoprotein (also known as CD90) is a glycophosphatidylinositol-anchored cell surface protein that has been used as a marker for a variety of stem cells, as well...

      • Transmembrane protease serine 5 (TMPRSS5)

        Transmembrane protease serine 5, TMPRSS5 (also known as spinesin) is a membrane-bound serine protease. It is mainly expressed in the brain, particulrly in neurons, their axons, ...

      • Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)

        Tumor necrosis factor receptor superfamily member 12A (also known as tweak-receptor and CD266) is a type I membrane protein receptor for TNFSF12/TWEAK. It is a weak inducer of a...

      • Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)

        Tumor necrosis factor receptor superfamily member 21 (also known as death receptor 6) is a cell surface receptor of the TNFR superfamily, which activates the JNK and NF-?B pathw...

      • Tumor necrosis factor receptor superfamily member 27 (EDA2R)

        Tumor necrosis factor receptor superfamily member 27, EDA2R (also known as ectodysplasin A2 receptor) is a type III transmembrane protein that functions as a receptor for ectody...

      • WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 (WFIKKN1)

        WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 (WFIKKN1) is a protease-inhibitor that contains multiple distinct protease inhibitor domains. These struct...