• Proseek Multiplex Organ Damage

    Casting a broader net to further explore the complexity of the human proteome

    Complementing and expanding on our previous portfolio of disease area-focused biomarker panels, our exploratory series offers scientists the chance to cast a wider net in the quest to identify new biomarkers and relevant protein signatures, offering many new assays focused on important biological processes with wide-ranging clinical relevance.

    The Organ Damage panel offers simultaneous analysis of 92 protein biomarkers using just 1 µL of biological sample, and all assays are subject to Olink’s strict technical validation and QC control procedures. The selection of protein biomarker assays is designed to provide the optimal dynamic range, as well as to focus on proteins relevant for processes involved in biological response to organ damage. Categorization of the proteins included in the panel was carried out via referral to widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET. The assays in this panel include proteins involved in key biological processes such as response to stress, regulation of cell proliferation, cell cycle, and cell death/apoptosis.

    An alphabetical list of the 92 proteins with links to the individual biomarker pages containing additional information and assay validation data can be found at the bottom of this page.

    An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data.

    Biological Process

    Disease Area

    Tissue Expression

    Protein Class

     

    A comprehensive list of all protein biomarkers that can be measured using the currently available biomarker panels can be seen on the biomarker library page.

    Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>

    If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.

    The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.

  • Search all our biomarkers

      Biomarkers in Proseek Multiplex Organ Damage

      • [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)

        Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.

      • 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)

        Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to redu...

      • Adhesion G-protein coupled receptor G1 (ADGRG1)

        Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collage...

      • Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

        ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitt...

      • Anterior gradient protein 2 homolog (AGR2)

        Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a ro...

      • Apoptosis-inducing factor 1, mitochondrial (AIFM1)

        Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol...

      • B-cell scaffold protein with ankyrin repeats (BANK1)

        Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.

      • BH3-interacting domain death agonist (BID)

        The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 d...

      • BMP and activin membrane-bound inhibitor homolog (BAMBI)

        Negatively regulates TGF-beta signaling.

      • C-type lectin domain family 1 member A (CLEC1A)

        C-type lectin domain family 1 member A is a protein encoded by the CLEC1A gene.

      • C-type natriuretic peptide (NPPC)

        Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive a...

      • Calcitonin (CALCA)

        Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Katacalcin is a potent p...

      • Calreticulin (CALR)

        Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin inter...

      • Carbonic anhydrase 12 (CA12)

        Reversible hydration of carbon dioxide.

      • Carbonic anhydrase 14 (CA14)

        Reversible hydration of carbon dioxide.

      • Casein kinase I isoform delta (CSNK1D)

        Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phospho...

      • Claspin (CLSPN)

        Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein whi...

      • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)

        It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on cert...

      • Cocaine esterase (CES2)

        Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl ...

      • Contactin-2 (CNTN2)

        In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels...

      • Corticoliberin (CRH)

        Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (B...

      • Desmoglein-4 (DSG4)

        Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transitio...

      • Dipeptidyl aminopeptidase-like protein 6 (DPP6)

        Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KC...

      • DNA topoisomerase 2-beta (TOP2B)

        Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

      • Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2)

        In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with d...

      • Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6)

        Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially...

      • EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)

        Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulati...

      • Enteropeptidase (TMPRSS15)

        Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin ...

      • Epidermal growth factor-like protein 7 (EGFL7)

        Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the ex...

      • Erbin (ERBIN)

        Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state...

      • Erythropoietin (EPO)

        Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

      • Fatty acid-binding protein 9 (FABP9)

        Fatty acid-binding protein 9 is a protein encoded by the FABP9 gene.

      • Forkhead box protein O1 (FOXO1)

        Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE...

      • Fructose-2,6-bisphosphatase TIGAR (TIGAR)

        Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intr...

      • Hematopoietic prostaglandin D synthase (HPGDS)

        Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggr...

      • Inactive tyrosine-protein kinase 7 (PTK7)

        Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt sign...

      • Integrin beta-1-binding protein 1 (ITGB1BP1)

        Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heter...

      • Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA)

        Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Re...

      • Kidney Injury Molecule (KIM1)

        May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidney injury and repair....

      • Leukotriene A-4 hydrolase (LTA4H)

        Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

      • Linker for activation of T-cells family member 2 (LAT2)

        Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B...

      • Lutropin subunit beta (LHB)

        Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

      • Macrophage erythroblast attacher (MAEA)

        Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with t...

      • Macrophage-capping protein (CAPG)

        Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage funct...

      • Melanoma-associated antigen D1 (MAGED1)

        Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act a...

      • Methionine aminopeptidase 1 (METAP1)

        Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small an...

      • Mevalonate kinase (MVK)

        May be a regulatory site in cholesterol biosynthetic pathway.

      • Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)

        May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.

      • Mothers against decapentaplegic homolog 1 (SMAD1)

        Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates t...

      • NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)

        NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22...

      • NEDD8 ultimate buster 1 (NUB1)

        Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8...

      • Neutrophil cytosol factor 2 (NCF2)

        NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

      • Nibrin (NBN)

        Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is inv...

      • Nitric oxide synthase, endothelial (NOS3)

        Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth ...

      • Nucleobindin-2 (NUCB2)

        Calcium-binding protein. May have a role in calcium homeostasis. Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intak...

      • Parvalbumin alpha (PVALB)

        In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

      • Paxillin (PXN)

        Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

      • Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)

        Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomeri...

      • Perilipin-1 (PLIN1)

        Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays...

      • Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)

        Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, th...

      • Placenta growth factor (PGF)

        Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1...

      • Platelet-derived growth factor C (PDGFC)

        Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattra...

      • Pleiotrophin (PTN)

        Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplasti...

      • Plexin domain-containing protein 1 (PLXDC1)

        Plays a critical role in endothelial cell capillary morphogenesis.

      • Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)

        Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein rece...

      • Probetacellulin (BTC)

        Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

      • Programmed cell death protein 1 (PDCD1)

        Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antig...

      • Prolow-density lipoprotein receptor-related protein 1 (LRP1)

        Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in ...

      • Proteasome subunit alpha type-1 (PSMA1)

        The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at ...

      • Protein amnionless (AMN)

        Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the productio...

      • Protein enabled homolog (ENAH)

        Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial a...

      • Protein fosB (FOSB)

        FosB interacts with Jun proteins enhancing their DNA binding activity.

      • Protein max (MAX)

        Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a trans...

      • Protein phosphatase 1B (PPM1B)

        Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it ...

      • Ras association domain-containing protein 2 (RASSF2)

        Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degrada...

      • Ras GTPase-activating protein 1 (RASA1)

        Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.

      • Receptor-type tyrosine-protein phosphatase eta (PTPRJ)

        Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, O...

      • Renin receptor (ATP6AP2)

        Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin ...

      • REST corepressor 1 (RCOR1)

        Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NR...

      • Retinoic acid receptor responder protein 1 (RARRES1)

        Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.

      • Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

        Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contai...

      • Serpin A9 (SERPINA9)

        Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).

      • Serum paraoxonase/arylesterase 2 (PON2)

        Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid pe...

      • Syntaxin-8 (STX8)

        Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

      • Syntaxin-binding protein 3 (STXBP3)

        Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in ad...

      • Troponin I, cardiac muscle (TNNI3)

        Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

      • Tyrosine-protein kinase Fes/Fps (FES)

        Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and ce...

      • Tyrosine-protein kinase Fgr (FGR)

        Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, includin...

      • Tyrosine-protein kinase Yes (YES1)

        Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation....

      • Vascular endothelial growth factor C (VEGFC)

        Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May f...

      • Vasohibin-1 (VASH1)

        Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial ...

      • Wiskott-Aldrich syndrome protein (WAS)

        Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possibl...