• Olink publications classified by disease area or biology

    On this find you will find our latest publication list, with the papers categorized according to the major disease area(s) addressed by the reported study. Within each category, papers are grouped by year of publication and sorted alphabetically by first author. In some cases, the article may appear in more than one category where appropriate. To jump directly to the areas of interest further down on this page, please click the appropriate link below:

    Cardiovascular diseases
    Cardiovascular/metabolic diseases
    Cardiovascular/renal and Cardiovascular/respiratory diseases
    Dermatological diseases
    Developmental biology
    Endocrine disorders
    Environmental toxicology
    Hematology
    Hepatology
    Immunological diseases/Immunology
    Immunotherapy
    Infectious diseases
    Inflammatory diseases
    Metabolic diseases
    Nephrology
    Neurology
    Neurovascular disease
    Nutritional science
    Obstetrics
    Oncology
    Opthalmology
    Other diseases & syndromes
    Respiratory disease
    Technical studies (no specific disease focus)
    Urology
    Wider proteomics studies (no specific disease focus)

    Cardiovascular diseases

    2020

    Ahmed A, Ahmed S, Arvidsson M, et. al. Elevated plasma sRAGE and IGFBP7 in heart failure. (2020) ESC Heart Failure, DOI: 10.1002/ehf2.12772
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    Ahmed S, Ahmed A, Bouzina H, Lundgren J and Rådegran R. Elevated plasma endocan and BOC in heart failure patients decrease after heart transplantation in association with improved hemodynamics. (2020) Heart and Vessels, DOI: 10.1007/s00380-020-01656-3
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    Ahmed S, Ahmed A, Säleby J, Bouzina H, Lundgren J and Rådegran G. Elevated plasma tyrosine kinases VEGF-D and HER4 in heart failure patients decrease after heart transplantation in association with improved haemodynamics. (2020) Heart and Vessels, DOI: 10.1007/s00380-019-01548-1
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    Bouwens E, van den Berg V, v M, Baart S, Caliskan K, Brugts J, Mouthaan H, van Ramshorst J, Germans T, Umans V, Boersma E and Kardys I. Circulating Biomarkers of Cell Adhesion Predict Clinical Outcome in Patients with Chronic Heart Failure. (2020) Journal of Clinical Medicine, DOI: 10.3390/jcm9010195
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    Bouzina H and Rådegran G. Plasma adrenomedullin peptides and precursor levels in pulmonary arterial hypertension disease severity and risk stratification. (2020) Pulmonary Circulation, DOI: 10.1177/2045894020931317
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    Bouzina H, Hesselstrand R and Rådegran G. Plasma insulin-like growth factor binding protein 1 in pulmonary arterial hypertension. (2020) Scandinavian Cardiovascular Journal, DOI: 10.1080/14017431.2020.1782977
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    deFilippi C, Toribio M, Wong LP, et. al. Differential Plasma Protein Regulation and Statin Effects in HIV-infected and Non-HIV-infected Patients Utilizing a Proteomics Approach Protein Regulation and Statin Effects in HIV. (2020) Journal of Infectious Diseases, DOI: 0.1093/infdis/jiaa196
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    Edfors R, Lindhagen L, Spaak J, et. al. Use of proteomics to identify biomarkers associated with chronic kidney disease and long‐term outcomes in patients with myocardial infarction. (2020) Journal of Internal Medicine, DOI: 10.1111/joim.13116
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    Fernandez C, Rysä J, Ström K, et. al. Circulating protein biomarkers predict incident hypertensive heart failure independently of N‐terminal pro‐B‐type natriuretic peptide levels. (2020) ESC Heart Failure, DOI: 10.1002/ehf2.12757
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    Ferreira JP, Xhaard C, Lamiral Z, et. al. PCSK9 Protein and rs562556 Polymorphism Are Associated With Arterial Plaques in Healthy Middle‐Aged Population: The STANISLAS Cohort. (2020) Journal of the American Heart Association, DOI: 10.1161/JAHA.119.014758
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    Garshick M, Baumer Y, Dey A, et. al. Characterization of PCSK9 in the Blood and Skin of Psoriasis. (2020) Journal of Investigative Dermatology, DOI: 10.1016/j.jid.2020.05.115
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    Kiouptsi K, Pontarollo G, Todorov H, et. al. Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice. (2020) Gut Microbes, DOI: 10.1080/19490976.2020.1767463
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    Klimczak‐Tomaniak D, Bouwens B, Schuurman A-S, et. al. Temporal patterns of macrophage‐ and neutrophil‐related markers are associated with clinical outcome in heart failure patients. (2020) ESC Heart Failure, DOI: 10.1002/ehf2.12678
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    Lind L, Gigante B, Borne Y, et. al. The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb: A meta-analysis and a longitudinal evaluation. (2020) Journal
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    Lombardi CM, Ferreira JP, Carubelli V, Anker S, Cleland J, Dickstein K, Filippatos G, Lang C, Ng L, Ponikowski P, Samani N, van Veldhuisen D, Zannad F, Voors A and Metra M. Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study. (2020) Clinical Research in Cardiology, DOI: 10.1007/s00392-019-01588-7
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    Medic Spahic J, Ricci, F, Aung, N, et. al.  Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome. (2020) BMC Cardiovascular Disorders, DOI: 10.1186/s12872-020-01465-6
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    Miñana G, Núñez J, Bayés‐Genís A, Revuelta‐López E, Ríos‐Navarro C, Núñez E, Chorro F, López‐Lereu MP, Monmeneu JV, Lupón J, Sanchis J and Lupón V. Role of PCSK9 in the course of ejection fraction change after ST‐segment elevation myocardial infarction: a pilot study. (2020) ESC Heart Failure, DOI: 10.1002/ehf2.12533
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    Molvin J, Jujic A, Melander O, Pareek M, Råstam L, Lindblad U, Daka B, Leosdottir M, Nilsson P, OLsen M and Magnusson M. Exploration of pathophysiological pathways for incident atrial fibrillation using a multiplex proteomic chip. (2020) Openheart, DOI: 10.1136/openhrt-2019-001190
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    Nelson C, Sama I, Codd V, et. al. Genetic Associations with Plasma ACE2 Concentration: Potential Relevance to COVID-19 Risk. (2020) Circulation, DOI: 10.1161/CIRCULATIONAHA.120.049007
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    Niersmann C, Röhrig K, Blüher M, Roden M, Herder C and Carstensen-Kirberg M. Proinflammatory Proteins in Primary Human Adipocytes and Activation of the Inflammatory NFĸB, p38, and ERK Pathways upon Omentin Treatment. (2020) Obesity Facts, DOI: 10.1159/000506405
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    Previtiali S, Gidaro T, Diaz-Manera J, et. al. Rimeporide as a first- in-class NHE-1 inhibitor: Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy. (2020) Pharmacological Research, DOI: 10.1016/j.phrs.2020.104999
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    Sama I, Ravera A, Santema B, et. al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors. (2020) European Heart Journal, DOI: 10.1093/eurheartj/ehaa373
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    Surhs H, Schroder J, Bové K, et. al. Inflammation, non-endothelial dependent coronary microvascular function and diastolic function—Are they linked? (2020) PLOS ONE, DOI: 10.1371/journal.pone.0236035
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    Tancin Lambert A, Kong X, Ratajczak-Tretel B, Atar D, Russell D, Skjelland M, Bjerkeli V, Skagen K, Coq M, Schordan E, Firat H, Halvorsen B and Aamodt A. Biomarkers Associated with Atrial Fibrillation in Patients with Ischemic Stroke: A Pilot Study from the NOR-FIB Study. (2020) Cerebrovascular Diseases Extra, DOI: 10.1159/000504529
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    Tromp J, Boerman L, Sama I, Maass S, Maduro J, Hummel Y, Berger M, de Bock G, Gietema J, Berendsen A and van der Meer P. Longterm survivors of early breast cancer treated with chemotherapy are characterized by a proinflammatory biomarker profile compared to matched controls (2020) European Journal of Heart Failure, DOI: 10.1002/ejhf.1758
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    Tromp J, Voors A, Sharma A, Ferreira J, Ouwerkerk W, Hillege H, Gomez K, Dickstein K, Anker S, Metra M, Lang C, Ng L, van der Harst P, van Veldhuisen D, van der Meer P, Lam C, Zannad F and Sama I. Distinct Pathological Pathways in Patients With Heart Failure and Diabetes. (2020) JACC: Heart Failure, DOI: 10.1016/j.jchf.2019.11.005
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    Wu P-H, Lin Y-T, Wu P-Y, Lee H-H, Lee S-C, Hung S-C, Chen S-C, Kuo M-C and Chiu Y-W. Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients: A Cross-Sectional Study. (2020) Journal of Clinical Medicine, DOI: 10.3390/jcm9010124
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    Wu S, Noren Hooten N, Freeman, et. al. Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration. (2020) Journal of Translational Medicine, DOI: 10.1186/s12967-020-02398-6
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    Yang X, Yang W, McVey D, Zhao G, Hu J, Poston R, Ren M, Willeit K, Coassin S, Willeit J, Webb T, Samani N, Mayr M, Kiech S and Ye S. FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease–Associated Genetic Variant and Influences Monocyte Transendothelial Migration. (2020) Journal of the American Heart Association, DOI: 10.1161/JAHA.119.014333
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    2019

    Ahmed A, Ahmed S, Arvidsson M, Bouzina H, Lundgren J and Rådegran G. Prolargin and matrix metalloproteinase‐2 in heart failure after heart transplantation and their association with haemodynamics. (2019) ESC Heart Failure, DOI: 10.1002/ehf2.12560
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    Alhamdow A, Lindh C, Albin M, Gustavsson P,  Tinnerberg H,  and Broberg K. Cardiovascular disease-related serum proteins in workers occupationally exposed to polycyclic aromatic hydrocarbons. (2019) Toxicological Science, doi: 10.1093/toxsci/kfz142
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    Arvidsson M, Ahmed A, Bouzina H and Rådegran, G. Matrix Metalloproteinase 7 in Diagnosis and Differentiation of Pulmonary Arterial Hypertension. (2019) Pulmonary Circulation, DOI: 10.1177/2045894019895414
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    Bao X, Borné Y, Yin S, Niu K, Orho-Melander M, Nilsson J, Melander O and Engström G. The associations of self-rated health with cardiovascular risk proteins: a proteomics approach. (2019) Clinical Proteomics, DOI: 10.1186/s12014-019-9258-9
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    Bom M, Levin E, Driessen R, Danad I, Van Kuijk, van Rossum A, Narula J, Min J, Leipsic J, Belo Pereira J, Taylor C, Nieuwdorp M, Raijmakers P, Koenig W, Groen A, Stroes E and Knaapen P. Predictive value of targeted proteomics for coronary plaque morphology in patients with suspected coronary artery disease. (2019) EBioMedicine, doi.org/10.1016/j.ebiom.2018.12.033
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    Borné Y, B, Sallsten G, Hedblad B, Persson M, Melander O, Nilsson J, Orho-Melander M, Barregard L and Engström G. Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study. (2019) Clinical Proteomics, doi: /10.1186/s12014-019-9231-7
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    Bouwens E, Brankovic M, Mouthaan H, Baart S, Rizopoulos D, van Boven N, Caliskan K, Manintveld O, Germans T, van Ramshorst J, Umans V, Akkerhuis KM and Kardys I. Temporal Patterns of 14 Blood Biomarker candidates of Cardiac Remodeling in Relation to Prognosis of Patients With Chronic Heart Failure—The Bio-SHiFT Study. (2019) Journal of the American Heart Association, DOI: 10.1161/JAHA.118.009555
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    Bouzina H, Hesselstrand R and Rådegran, G. Higher plasma fibroblast growth factor 23 levels are associated with a higher risk profile in pulmonary arterial hypertension. (2019) Pulmonary Circulation, DOI: 10.1177/2045894019895446
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    Chong M, Sjaarda J, Pigeyre M, Mohammadi-Shemirani P, Lali R, Shoamanesh A, Chaim Gerstein H and Paré G. Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome. (2019) Circulation, doi/10.1161/CIRCULATIONAHA.119.040180
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    Chua W, Purmah Y, Cardoso V, Gkoutos G, Tull S, Neculau G, Thomas M, Kotecha D, Lip G, Kirchhof P and Fabritz L. Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation. (2019) Eur. Heart  J., doi.org/10.1093/eurheartj/ehy815
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    Cresci S, Pereira N, Ahmad F, Byku M, de las Fuentes L, Lanfear D, Reilly C, Owens A and Wolf M. Heart Failure in the Era of Precision Medicine: A Scientific Statement From the American Heart Association. (2019) Circulation: Genomic and Precision Medicine, doi: abs/10.1161/HCG.0000000000000058
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    De With R, Marcos E, Dudink E, Spronk H, Crijins H, RienstraM and Van Gelder I. Atrial fibrillation progression risk factors and associated cardiovascular outcome in well-phenotyped patients: data from the AF-RISK study. (2019) EP Europace, DOI: 10.1093/europace/euz339
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    Fellström B, Helmersson-Karlqvist J, Lind , Soveri I, Wu P-H, Thulin M, Ärnlöv J and Larsson A. Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females. (2019) Journal of Interferon & Cytokine Research, doi: 10.1089/jir.2019.0074
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    Ferreira JP, Duarte K, Woehrle H, Cowie M, Angermann C, d’Ortho M-P, Erdmann E, Levy P, Simonds A, Somers V, Teschler H, Wegscheider K, Bresso E, Dominique‑Devignes M, Rossignol P, Koenig W and Zannad F. Bioprofiles and mechanistic pathways associated with Cheyne-Stokes respiration: insights from the SERVE-HF trial. (2019) Clinical Research in Cardiology, DOI: 10.1007/s00392-019-01578-9
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    Ferreira JP, Duarte K, Woehrle H, Cowie M, Wegscheider K, Angermann C, Angermann M-P, Erdmann E, Levy P, Simonds A, Somers V, Teschler H, Rossignol P, Koenig W and Zannad F. Biomarkers in patients with heart failure and central sleep apnoea: findings from the SERVE-HF trial. (2019) ESC Heart Failure, DOI: : 10.1002/ehf2.12521
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    Ferreira, JP, Metra M, Anker S, Dickstein K, Lang C, Ng L, Samani N, Cleland J, van Veldhuisen D, Voors A and Zannad F. Clinical correlates and outcome associated with changes in 6‐minute walking distance in patients with heart failure: findings from the BIOSTAT‐CHF study. (2019) Eur. J. Heart Failure, doi.org/10.1093/eurheartj/ehy815
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    Ferreira JP, Verdonschot J et al. Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure. The HOMAGE study. (2019) Circulation Heart Failure, DOI: 10.1161/CIRCHEARTFAILURE.118.005897
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    Gidlöf O, Evander M, Rezeli M, Marko-Varga G, Laurell T and Erlinge D. Proteomic profiling of extracellular vesicles reveals additional diagnostic biomarkers for myocardial infarction compared to plasma alone. (2019) Scientific Reports, doi /10.1038/s41598-019-45473-9
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    Gonçalves I, Singh P, Tengryd C, Cavalera M, Yao Mattisson I, Nitulescu M, Flor Person A, Volkov P, Engström G,Orho-Melander M, Nilsson J and Edsfeldt A. (2019) sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events. Stroke, doi: 10.1161/STROKEAHA.119.024379
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    Hedman Å, Hage C, Sharma A, Brosnan MJ, Buckbinder L, Gan L-M, Shah S, Linde C, Donal E, Daubert J-C, Mälarstig A, Ziemek D and Lund L. Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning. (2019) Heart, DOI: 10.1136/heartjnl-2019-315481
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    Hoes M, Tromp J, Ouwerkerk W, Bomer N, Oberdorf-Maass S, Samani N, Ng L, Lang C, van der Harst P, Hillege H, Anker S, Metra M, van Veldhuisen D, Voors A and van der Meer P. The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach. (2019) European Journal of Heart Failure, DOI: 10.1002/ejhf.1674
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    Kraen M, Frantz S, Nihlén U, Engström G, Löfdahl C, Wollmer P and Dencker M. Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking (2019) PLOS One, doi.org/10.1371/journal.pone.0211987
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    Lemming E, Byberg L, Stattin K, Ahmad S, Lind L, Elmståhl S, Larsson S, Wolk A and Michaëlsson K. Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross‐Sectional Study in 2 Independent Cohorts. (2019) Journal of the American Heart Association, doi: 10.1161/JAHA.118.011860
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    Lin Y-T, Fall T, Hammar U, Gustafsson S, Ingelsson E, Ärnlöv J, Lind L, Engström G and Sundström J. Proteomic Analysis of Longitudinal Changes in Blood Pressure. (2019) Journal of Clinical Medicine, doi: 10.3390/jcm8101585
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    Markstad H, Edsfeldt A, Yao Mattison I, Bengtsson E, Singh P, Cavalera M, Asciutto G, Björkbacka H, Nordin Fredrikson G, Dias N, Volkov P,  Orho-Melander M, Nilsson J, Engström G and Gonçalves I. High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke. (2019) Journal of the American Heart Association, doi: 10.1161/JAHA.118.009874
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    McGilligan V, Watterson S, Rjoob K, Chemaly M, Bond R, Iftikhar A, Knoery C, Leslie S, McShane A, Bjourson A and Peace A. An exploratory analysis investigating blood protein biomarkers to augment ECG diagnosis of ACS (2019) Journal of Electrocardiology, doi: 10.1016/j.jelectrocard.2019.09.002
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    Memon A, Zarrouk M, Ågren-Witteschus S, Sundquist J, Gottsäter A and Sundquist K. Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm (2019) European Journal of Preventive Cardiology, doi: 10.1177/2047487319873062
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    Ong KL, Chung RWS, Hui N, Festin K, Lundberg AK, Rye K-A, Jonasson L and Kristenson M. Usefulness of Certain Protein Biomarkers for Prediction of Coronary Heart Disease. (2019) American Journal of Cardiology, DOI: 10.1016/j.amjcard.2019.11.016
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    Rullman E, Melin M, Mandić M, Gonon A, Fernandez‑Gonzalo R and Gustafsson T. Circulatory factors associated with function and prognosis in patients with severe heart failure (2019) Clinical Research in Cardiology, dooi: 10.1007/s00392-019-01554-3
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    Schroder J, Mygind N, Frestad D, Michelsen M, Suhrs H, Bove K, Gustafsson I, Kastrup J and Prescott E. Pro-inflammatory biomarkers in women with non-obstructive angina pectoris and coronary microvascular dysfunction. (2019) IJC Heart & Vasculature, doi: /10.1016/j.ijcha.2019.100370
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    Schulte C, Barwari T, Joshi A, Theofilatos K, Zampetaki A, Barallobre-Barreiro J, Sing B, Sörensen N, Neumann J, Zeller T, Westermann D, Blankenberg S, Marber M, Liebetrau C and Mayr M. Comparative Analysis of Circulating Non-Coding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. (2019) Circulation Research, DOI: 0.1161/CIRCRESAHA.119.314937
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    Shavadia J, Granger C, Alemayehu W, Povsic T, Brener S, van Diepen S, Defilippi C and Armstrong P. High throughout targeted proteomics discovery approach and spontaneous reperfusion in ST-segment elevation myocardial infarction. (2019) American Heart Journal, DOI: 10.1016/j.ahj.2019.09.015
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    Stattin K, Lind L, Elmsta S, Wolk A, Warensjö E, Melhus H, Michaëlsson K and Byberg L. Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts (2019) Eur. J. Prevent. Cardiology, doi: 10.1177/2047487319868033
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    Säleby J, Bouzina H, Ahmed S, Lundgren J and Rådegran G. Plasma receptor tyrosine kinase RET in pulmonary arterial hypertension diagnosis and differentiation. (2019) ERJ Open Research,  DOI: 10.1183/23120541.00037-2019
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    Södergren A, Bengtsson C, Möllers B, Rantapää-Dahlqvist S and Wållberg-Jonsson S. Biomarkers associated with cardiovascular disease in patients with early rheumatoid arthritis. (2019) PlosOne, doi: 10.1371/journal.pone.0220531
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    Tromp J, Hage C, Oowerkerk W, Sanders-van Wijk S, Svedlund S, Saraste A, Ljung Faxén U, Lagerstrom Fermer M, Gan L-M, Lund L, Shah S and Lam C. Biomarker Correlates of Coronary Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction. (2019) Circulation, doi: 10.1161/CIRCULATIONAHA.119.042569
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    Uderhardt S, Ackermann J, Fillep, Hammond V, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner K, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz‑Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins P, Schabbauer G, Mackman N, Voehringer D, Nadler J, Lee J, Massberg S, Rauh M, Kiechl S, Schett G, O’Donnell V and Krönkel G. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. (2019) Experimental Medicine, DOI: 10.1084/jem.20161070
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    van den Berg V, Bouwens E, Umans V, de Maat M, Manintveld O, Caliskan K, Constantinescu A, Caliskan K, Constantinescu A, Mouthaan H, Cornel J-H, Baart S, Akkerhuis M, Boersma E and Kardys I. Longitudinally Measured Fibrinolysis Factors are Strong Predictors of Clinical Outcome in Patients with Chronic Heart Failure: The Bio-SHiFT Study. (2019) Thrombosis and Haemostasis, DOI: 10.1055/s-0039-1696973
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    van der Zwan M, Hesselink D, Clahsen-van Groningen M and Baan C. Targeted proteomic analysis detects acute T cell-mediated kidney allograft rejection in belatacept-treated patients. (2019) Therapeutic Drug Monitoring, doi: 10.1097/FTD.0000000000000587
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    Wu P-H, Chiu Y-W, Zou H-B, Lee S-C, Lin Y-T, Tsai Y-T, Kuo M-C and Hwang S-J. Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach. (2019) Nutrition, DOI: 10.3390/nu11123033
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    2018

    Arrigo M, Vodovar N,Von Moos S, Masson E, Segerer S, Cippà P and Mebazaa A. High accuracy of proximity extension assay technology for the quantification of plasma brain natriuretic peptide. (2018) Journal of  Clinical Laboratory Analysis, doi.org/10.1002/jcla.22574
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    Barwari T, Eminaga S, Mayr U, Lu R, Armstrong P, Chan M, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley S, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah A, Ghevaert C, Warner T, Fernández-Hernando C, Suárez Y and Mayr M. Inhibition of profibrotic microRNA-21 affects platelets and their releasate. (2018) Journal of Clinical Investigation, doi.org/10.1172/jci.insight.123335.
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    Berntsson J, Smith G, Johnson L, Söderholm M, Borné Y, Melander O, Orho-Melander M, Nilsson J and Engström G. Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke. (2018) Heart, doi:10.1136/heartjnl-2018-313684
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    Borné Y, Gränsbo K, Nilsson J, Melander O, Orho-Melander M, Smith G and Engström G. Vascular Endothelial Growth Factor D, Pulmonary Congestion, and Incidence of Heart Failure. (2018) JACC, doi.org/10.1016/j.jacc.2017.11.058
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    Bouzina H and Rådergran G. Low plasma stem cell factor combined with high transforming growth factor-α identifies high-risk patients in pulmonary arterial hypertension. (2018) ERJ Open Research, DOI: 10.1183/23120541.00035-2018.
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    Brankovic M, Akkerhuis K, Mouthaan H, Brugts J, Manintveld O, van Ramshorst J, Germans T, Umans V, Boersma E and Kardys I. Cardiometabolic biomarkers and their temporal patterns predict poor outcome in chronic heart failure (Bio-SHiFT study). (2018) The Journal of Clinical Endocrinology & Metabolism, DOI: 10.1210/jc.2018-01241
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    Brankovic M, Akkerhuis K, Mouthaan H, Constantinescu A, Caliskan K, van Ramshorst J, Germans T, Umans V and Kardys I. Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure.(2018) International Journal of Cardiology, DOI: 10.1016/j.ijcard.2018.08.001
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    Dencker M, Gårdinger Y, Björgell O and Hlebowicz J. Effect of food intake on biomarkers for cardiovascular disease and inflammation analyzed with the Proseek Multiplex CVD II kit. (2018) Genetics and Molecular Research, DOI: 10.4238/gmr16039884
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    Enroth S, Maturi, V, Berggrundi, M, Bosdotter Enroth S, Moustakas A, Johansson Å and Gyllensten U. Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases. (2018) Scientific Reports, DOI:10.1038/s41598-018-23860-y
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    Feldreich T, Nowak C, Fall T, Carlsson A, Carrero J-J, Ripsweden J, Qureshi AR, Heimbürger O, Barany P, Stenvinke P, Vuilleumier N, Kalra P, Green D and Ärnlöv J. Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease. (2018) Journal of Nephrology, doi: 10.1007/s40620-018-0556-5
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    Figarska S, Gustafsson S, Sundström J, Ärnlöv J, Mälarstig A, Elmståhl S, Fall T, Lind L and Ingelsson E. Associations of Circulating Protein Levels With Lipid
    Fractions in the General Population
    (2018) Arteriosclerosis, Thrombosis, and Vascular Biology, doi:/10.1161/ATVBAHA.118.311440
    Article link>

    Gezelius E, Flou Kristensen A, Bendahl P, Hisada Y, Risom Kristensen S, Ek L, Bergman B, Wallberg M, Falkmer U, Mackman N, Pedersen S and Belting M. Coagulation biomarkers and prediction of venous thromboembolism and survival in small cell lung cancer: A sub-study of RASTEN – A randomized trial with low molecular weight heparin. (2018) PLOS ONE, doi: 10.1371/journal.pone.0207387
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    Grufman H, Yndigegn T, Gonçalves I, Nilsson J and Schiopu A. Elevated IL-27 in patients with acute coronary syndrome is associated with adverse ventricular remodeling and increased risk of recurrent myocardial infarction and cardiovascular death (2018) Cytokine, doi.org/10.1016/j.cyto.2017.11.002
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    Halak S, Östling G, Edsfeldt A, Kennbäck C, Dencker M, Gonçalves I and Asciutto G. Spotty Carotid Plaques Are Associated with Inflammation and the Occurrence of Cerebrovascular Symptoms (2018) Cerebrovascular Diseases Extra, doi.org/10.1159/000485258
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    Holm Nielsen S, Tengryd C, Edsfeldt A, Brix S, Genovese F, Bengtsson E, Karsdal M, Leeming D, Nilsson J and Goncalves I. Markers of Basement Membrane Remodeling Are Associated With Higher Mortality in Patients With Known Atherosclerosis. (2018) Journal of the American Heart Association, DOI: 10.1161/JAHA.118.009193
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    Johansson M, Ricci F, Aung N, Sutton R, Melander O and  Fedorowski A. Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension (2018) Hypertension, doi.org/10.1161/HYPERTENSIONAHA.117.10365
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    Johansson M, Ricci F, Aung N, Sutton R, Melander O and  Fedorowski A. Inflammatory biomarker profiling in classical orthostatic hypotension: Insights from the SYSTEMA cohort (2018) Int. J. Cadiol., doi.org/10.1016/j.ijcard.2017.12.020
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    Kulasingam A, Hvas A-M, Lerkevang Grove E, Løkke Funck K and Dalby Kristensen S. Detection of biomarkers using a novel proximity extension assay in patients with ST-elevation myocardial infarction. (2018) Thrombosis Research, doi.org/10.1016/j.thromres.2018.10.011
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    Lendvai N, Tsakos I, Devlin S.,Schaffer W, Hassoun H, Lesokhin A, Landau H, Korde H, Mailankody S, Smith E, Chung D, Koehne G, Shah G, Alexander A, Patel M, Ballagi A, Grundberg I, Giralt S and Landgren O. Predictive biomarkers and practical considerations in the management of carfilzomib-associated cardiotoxicity (2018) Leukemia & Lymphoma, doi.org/10.1080/10428194.2017.1403020
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    Ljungberg J, Janiec M, Bergdah I, Holmgren A, Hultdin J, Johansson B, Näslund U, Siegbahn A, Fall T and Söderberg S. Proteomic Biomarkers for Incident Aortic Stenosis Requiring Valvular Replacement. (2018) Circulation, doi.org/10.1161/CIRCULATIONAHA.117.030414
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    Manor O, Zubair N, Conomos M, Xu X, Rohwer J, Krafft C, Lovejoy J and Magis A. A Multi-omic Association Study of Trimethylamine N-Oxide. (2018) Cell Reports, DOI: 10.1016/j.celrep.2018.06.096
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    Memon A, Sundquist K,  PirouziFard M,  Elf J,  Strandberg K,  Svensson P,  Sundquist J and Zöller B. Identification of novel diagnostic biomarkers for deep venous thrombosis. (2018) British Journal of Haematology, doi.org/10.1111/bjh.15206
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    Muhammad IF, Borné Y, Melander O, Orho-Melander M, Nilsson J, Söderholm M and Engström G. FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke (2018) Stroke, DOI: 10.1161/STROKEAHA.118.022063
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    Olsson KW, Larsson A, Jonzon A and Sindelar R. Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22–27 weeks’ gestation. (2018) Pediatric Research, doi.org/10.1038/s41390-018-0182-x
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    Ouwerkerk W, Zwinderman A, Ng L, Demissei B, Hillege H, Zannad F, van Veldhuisen D, Samani N, Ponikowski P, Metra M, ter Maaten J, Lang C van der Harst P, Filippatos G, Dickstein K, Cleland J, Anker S and Voors A. Biomarker-Guided Versus Guideline-Based Treatment of Patients With Heart Failure : Results From BIOSTAT-CHF. (2018) Journal of the American College of Cardiology, doi.org/10.1016/j.jacc.2017.11.041
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    Pan J, Michaëlsson E, Shaw P, Kuruvilla S, Kramer C, Gan L-M, Keeley E, and Salerno, M. Extracellular volume by cardiac magnetic resonance is associated with biomarkers of inflammation in hypertensive heart disease. (2018) Journal of hypertension, doi: 10.1097/HJH.0000000000001875
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    Santema B, Kloosterman M, Van Gelder I, Mordi I, Lang C, Lam C, Anker S, Cleland J, Dickstein K, Filippatos G, Van der Harst P, Hillege H, Ter Maaten J, Metra M, Ng L, Ponikowski P, Samani N, Van Veldhuisen D, Zwinderman A, Zannad F, Damman K, Van der Meer P, Rienstra M and Voors A. Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction. (2018) European Heart Journal, doi:10.1093/eurheartj/ehy421
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    Shore A, Colhoun H, Natali A, Palombo C, Khan F, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, Gates P, Looker H, Dove F, Belch J, Pinnola S, Venturi S, Kozakova M, Goncalves I, Kravic J, Björkbacka H and Nilsson J. Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study. (2018) Diabetes Care, doi: 10.2337/dc18-0185
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    Söderholm M and Engström G. Fibroblast Growth Factor 23 and Incidence of Subarachnoid Hemorrhage. (2018) Stroke, DOI: 10.1161/STROKEAHA.115.010565.
    Article link>

    ter Maaten J, Voors A, Damman K van der Meer P, Anker S, Cleland J, Dickstein K, Filippatos G, Harst P, Hillege H, Lang C, Metra M, Navis G, Ng L, Ouwerkerk W, Ponikowski P, Samani N, van Veldhuisen D, Zannad F, Zwinderman A and de Borst M. Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure (2018) International Journal of Cardiology,doi: 10.1016/j.ijcard.2017.10.010
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    Timotin A, Cinato M,Boal F, Dejean S, Anesia R, Arnaut O, Lagente C, Roncalli J, Desmoulin F, Tronchere H and Kunduzova O. Differential protein profiling as a potential multi-marker approach for obese patients with heart failure: A retrospective study. (2018) Scientific Reports, doi:, 10.1038/s41598-018-26118-9
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    Toribio M, Fitch K, Stone L, Zanni M, Loa J, de Filippi C, Sponseller C, Lee H, Grundberg I, Thompson M, Aberg J and Grinspoon S. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. (2018) EBioMedicine, doi.org/10.1016/j.ebiom.2018.08.039
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    Tromp J, Westenbrink D, Ouwerkerk W, van Veldhuisen D, Samani N, Ponikowski P, Metra M, Anker S, Cleland J, Dickstein K,  Filippatos G, van der Harst P, Lang, C, Ng L, Zannad F, Zwinderman A, Hillege H, van der Meer P and Voors A. Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction. (2018) JACC, doi.org/10.1016/j.jacc.2018.06.050
    Article link>

    Vohra A and  Asnani A. Biomarker Discovery in Cardio-Oncology. (2018) Current Cardiology Reports, doi.org/10.1007/s1188
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    Vroegindewey M, Oemrawsingh R, Kardys I, Asselbergs F, van der Harst P, Oude Ophuis A, Cramer G, Maas A, Hong Kie The S, Wardeh A, Mouthaan H, Boersma E and Akkerhuis M. The temporal pattern of immune and inflammatory proteins prior to a recurrent coronary event in post-acute coronary syndrome patients. (2018) Biomarkers, doi: 10.1080/1354750X.2018.1539768
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    Wigren M, Svenugnsson E, Yao Mattisson I, Gustafsson J, Gunnarsson I, Zickert A, Elvin K, Jensen-Urstad K, Bengtsson A, Gullstrand B, Nordin Fredrikson G and Nilsson J. Cardiovascular disease in systemic lupus erythematosus is associated with increased levels of biomarkers reflecting receptor-activated apoptosis (2018) Atherosclerosis, doi: 10.1016/j.atherosclerosis.2018.01.022
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    Zhernakova D, Le T, Kurilshikov A, Atanasovska B, Bonder M, Sanna S, Claringbould A, Võsa U, Deelen P, LifeLines cohort study, BIOS consortium, Franke L, de Boer R, Kuipers F, Netea M, Hofker M, Wijmenga C, Zhernakova A and Fu J. Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome. (2018) Nature Genetics, doi.org/10.1038/s41588-018-0224-7
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    2017

    Bayes-Genis A, Núñez J, Zannad F, Ferreira J, Anker S, Cleland J, Dickstein K, Filippatos G, Lang C, Ng L, Ponikowski P, Samani N, van Veldhuisen D, , Zwinderman A, Metra M, Lupón J and Voors A. The PCSK9-LDL Receptor Axis (2017) J. Am. College Cardiology, doi: 10.1016/j.jacc.2017.08.057
    PubMed link>

    Björkbacka H, Yao Mattisson I, Wigren M, Melander O, Fredrikson G, Bengtsson E, Gonçalves I, Almgren P, Lagerstedt J, Orho-Melander M, Engström G and Nilsson J. Plasma stem cell factor levels are associated with risk of cardiovascular disease and death. (2017) Journal of Internal Medicine, doi/10.1111/joim.12675
    Article link >

    Cornelis M,   Gustafsson S,  Ärnlöv J, Elmståhl S, Söderberg S,  Sundström J,   Michaëlsson K,  Lind L and Ingelsson E. Targeted proteomic analysis of habitual coffee consumption. (2017) Journal of Internal Medicine, doi.org/10.1111/joim.12703
    Article link>

    deFilippi C and Seliger S. A Multibiomarker Approach to Heart Failure Prognostication : A Work in Progress (2017) JACC: Heart Failure, doi.org/10.1016/j.jchf.2017.02.019 [editorial]
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    Dencker M, Gårdinger Y, Björgell O, and Hlebowicz J. Effect of food intake on 92 biomarkers for cardiovascular disease (2017) PLOS One, doi.org/10.1371/journal.pone.0178656
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    Drum C, Tan W, Chan S-P, Pakkiri L, Chong J, Liew O-W, Ng T-P, Ling L-H,  Sim D, Leong K-T, Yeo D, Ong H-Y,  Jaufeerally F, Wong R, Chai P, Low A, Davidsson P, Liljeblad M, Söderling A-S, Gan L-M, Bhat R, Purnamawati K, Lam C and Richards M. Thymosin Beta‐4 Is Elevated in Women With Heart Failure With Preserved Ejection Fraction (2017) Journal of the American Heart Association, doi.org/10.1161/JAHA.117.005586
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    Flintholm Raft K, Frestad D, Michelsen M, Suhrs H, Rask A, Nilsson M, Hermann T and Prescott E. Peripheral Endothelial Function and Coronary Flow Velocity Reserve Are Not Associated in Women with Angina and No Obstructive Coronary Artery Disease: The iPOWER Study (2017) Journal of Vascular Research, doi.org/10.1159/000479374
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    Folkersen L, Fauman E, Sabater-Lleal M, Strawbridge R, Frånberg M, Sennblad B, Baldassarre D, Veglia F, Humphries S, Rauramaa R, de Faire U, Smit A, Giral P, Kurl S, Mannarino E, Enroth S, Johansson Å, Bosdotter Enroth S, Gustafsson S, Lind L, Lindgren C, Morris A, Giedraitis V, Silveira A, Franco-Cereceda A, Tremoli E, IMPROVE study group , Gyllensten U, Ingelsson E, Brunak S, Eriksson P, Ziemek D, Hamsten A and Mälarstig A. Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. (2017) PLOS Genetics 13(4), doi.org/10.1371/journal.pgen.1006706
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    Gohar A, Gonçalves I, Vrijenhoek J, Haitjema S, van Koeverden I, Nilsson J, de Borst G, de Vries J-P, Pasterkamp G, den Ruijter H, Björkbacka H and de Jager S. Circulating GDF-15 levels predict future secondary manifestations of cardiovascular disease explicitly in women but not men with atherosclerosis (2017) International Journal of Cardiology, http://dx.doi.org/10.1016/j.ijcard.2017.03.101
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    Hage C, Michaëlsson E, Linde C, Donal E, Daubert J-C, Gan L-M and Lund L. Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction. (2017) Circulation: Cardiovascular Genetics, doi.org/10.1161/CIRCGENETICS.116.001633
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    Hofmann R, Tornvall P, Witt N, Alfredsson J, Svensson L, Jonasson L and Nilsson L. Supplemental oxygen therapy does not affect the systemic inflammatory response to acute myocardial infarction (2017) Journal of Internal Medicine, DOI: 10.1111/joim.12716
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    Langley S, Willeit K, Didangelos A, Perisic Matic L, Skroblin P, Barallobre-Barreiro J, Lengquist MN, Rungger G,Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B,Paulweber B, Willeit P, Shalhoub J, Pasterkamp G,Davies A, Monaco C, Hedin U, Shanahan C, Willeit J, Kiechl S and Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. (2017) Journal of  Clinical Investigation, doi:10.1172/JCI86924
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    Mahdessian H, Perisic Matic L, Lengquist M, Gertow K, Sennblad B, Baldassarre D, Veglia F, Humphries S, Rauramaa R, de Faire U, Smit A, Giral P, Kurl S, Mannarino E, Tremoli E, Hamsten A, Eriksson P, Hedin U, Mälarstig A, IMPROVE study group. Integrative Studies Implicate Matrix Metalloproteinase 12 as a Culprit Gene for Large-Artery Atherosclerotic Stroke. (2017) Journal of Internal Medicine, DOI: 10.1111/joim.12655
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    Mohammad M, Noc N, Lang I, Holzer M, Clemmensen P, Jensen U, Metzler B and Erlinge, D. Proteomics in Hypothermia as Adjunctive Therapy in Patients with ST-Segment Elevation Myocardial Infarction: A CHILL-MI Substudy (2017) Therapeutic Hypothermia and Temperature Management, doi.org/10.1089/ther.2016.0041
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    Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum J, Alexander V, Willeit J, Kiech S and Mayr M. Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III (2017) Journal of the American College of Cardiology, Vol 69 (7) DOI: 10.1016/j.jacc.2016.11.065 (Online Appendix)
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    Skau E, Henriksen E, Wagner P, Hedberg P, Siegbahn A and Leppert J. GDF-15 and TRAIL-R2 are powerful predictors of long-term mortality in patients with acute myocardial infarction (2017) European Journal of Preventive Cardiology, doi.org/10.1177/2047487317725017
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    Smith G and Gerszten R. Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease (2017) Circulation, doi.org/10.1161/CIRCULATIONAHA.116.025446
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    Stenemo M, Nowak C, Byberg L, Sundström J, Giedraitis V, Lind L, Ingelsson E, Fall T and Ärnlöv J. Circulating proteins as predictors of incident heart failure in the elderly (2017) European Journal of Heart Failure, doi: 10.1002/ejhf.980
    Article link>

    Sukma Dewi I, Gidlöf O, Hollander Z, Lam K, Benson M, Braun O, Nilsson J, Tebbutt S, Ng R,  Öhman J, McManus B and Smith G. Immunological Serum Protein Profiles for Noninvasive Detection of Acute Cellular Rejection After Heart Transplantation. (2017) Journal of the American College of Cardiology, doi.org/10.1016/j.jacc.2017.10.012
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    Uderhardt S, Ackermann J, Fillep T, Hammond V, Willeit J, Santer P, Mayr M, Biburger M, Miller M, Zellner K, Stark K, Zarbock A, Rossaint J, Schubert I, Mielenz D, Dietel B, Raaz‑Schrauder D, Ay C, Gremmel T, Thaler J, Heim C, Herrmann M, Collins P, Schabbauer G, Mackman N, Voehringer D, Nadler J, Lee J, Massberg S, Rauh M, Kiechl S, Schett G, O’Donnell V and Krönke G. Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease. JEM (2017), doi.org/10.1084/jem.20161070
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    Vallejo J,Dunér P, Fredrikson G, Nilsson J and Bengtsson E. Autoantibodies against aldehyde-modified collagen type IV are associated with risk of development of myocardial infarction. (2017) Journal of Internal Medicine, doi/10.1111/joim.12659/full
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    West N, Corrigan J, Owen R, Hoole S, Brown A, Blatcher S and Newby, A. Percutaneous Sampling of Local Biomolecule Gradients Across Coronary Artery Atherosclerotic Plaques.(2017) JACC: Basic to Translational Science, doi: 10.1016/j.jacbts.2017.07.007
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    Willeit K, Pechlaner R, Willeit P, Skroblin P, Paulweber B, Schernthaner C, Toell T, Egger G, Weger S, Oberhollenzer M, Kedenko L, Iglseder B, Bonora E, Schett G, Mayr M, Willeit J and Kiechl S. Association Between Vascular Cell Adhesion Molecule 1 and Atrial Fibrillation. JAMA Cardiology (2017), doi:10.1001/jamacardio.2017.0064
    Article link>

    2016

    Edsfeldt A, Bengtsson E, Asciutto G, Dunér P, Björkbacka H, Fredrikson G.N, Nilsson J, Goncalves I. High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy. Cerebrovasc Dis. (2016); 41:199-203
    Article link >

    Eisenberg T. et. al. Cardioprotection and lifespan extension by the natural polyamine spermidine (2016) Nature Medicine, DOI: 10.1038/nm.4222.
    PubMed link>

    Gonçalves I, Hultman K, Dunér, P, Edsfeldt A, Hedblad B, Nordin Fredrikson G, Björkbacka H, Nilsson J and Bengtsson E. High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.  Open Heart. (2016) 3: doi:10.1136
    Article link >

    Grönberg C, Asciutto G, Persson A, Nordin Fredrikson G, Nilsson J, Gonçalves I and Björkbacka H. Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up. (2016) Cytokine, doi.org/10.1016/j.cyto.2016.06.009
    Article link>

    Huang B, Svensson P, Ärnlov J, Sundström J, Lind L and Ingelsson E. Effects of cigarette smoking on cardiovascular-related protein profiles in two community-based cohort studies. (2016) Atherosclerosis, 10.1016/j.atherosclerosis.2016.09.014
    Article link>

    Lind L, Sundström J, Stenmo M, Hagström E and Ärnlöv J. Discovery of new biomarkers for atrial fibrillation using a custom-made proteomics chip. (2016) Heart, 10.1136/heartjnl-2016-309764
    Article link>

    Schiopu A, Bengtsson E, Goncalves I, Nilsson J, Nordin Fredrikson G and Björbacka H. Associations Between Macrophage Colony-Stimulating Factor and Monocyte Chemotactic Protein 1 in Plasma and First-Time Coronary Events: A Nested Case–Control Study. (2016) J. Am Heart Assoc., 10.1161/JAHA.115.002851
    Article link>

    Shaw P, Yang Y, Gonzalez J, Kuruvilla S, Gottbrecht M, Epstein F,Gan L, Keeley E, Kramer C, Salerno M. Extracellular volume by CMR is associated with serum biomarkers of extracellular matrix turnover and inflammation in hypertensive heart disease. Journal of Cardiovascular Magnetic Resonance (2016)  doi:10.1186/1532-429X-18-S1-O103
    Article link >

    2015

    Asciutto G, Dias NV, Edsfeldt A, Nitulescu M, Persson A, Nilsson M, Dunér P, Nilsson J, Gonçalves I. Low elastin content of carotid plaques is associated with increased risk of ipsilateral stroke. PLoS One. (2015) Mar 24;10(3):e0121086. doi: 10.1371/journal.pone.0121086.
    PubMed link >

    Helseth R, Weiss T, Opstad T, Siegbahn A, Solheim S, Freynhofer M, Huber K, Arnesen H and Seljeflot S. Associations between circulating proteins and corresponding genes expressed in coronary thrombi in patients with acute myocardial infarction. Thrombosis Res. (2015), 136: 1240-1244
    PubMed link >

    Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton A, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley S, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey R, Mayr M. Association of MicroRNAs and YRNAs with Platelet Function. Circ Res. (2015) Feb 5;118(3):420-32. doi: 10.1161/CIRCRESAHA
    Pubmed link >

    Lind L, Siegbahn A, Lindahl B, Stenemo M, Sundström J, Ärnlöv J. Discovery of new risk markers for ischemic stroke using a novel targeted proteomics chip. Stroke. (2015) Dec;46(12):3340-7. doi: 10.1161/STROKE AHA.115.010829
    PubMed link >

    Lind L, Ärnlöv J, Lindahl B, Siegbahn A, Sundström J, Ingelsson E. Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis. Atherosclerosis. (2015) Jul 14;242(1):205-210. doi: 10.1016/j.atherosclerosis.2015.07.023.
    PubMed link >

    Rattik S, Wigren M, Björkbacka H, Nordin Fredriksson G, Hedblad B, Siegbahn A, Bengtsson E, Schiopu A, Edsfeldt A, Dunér P, Grufman H, Concalves I and Nilsson J. High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events. Arterioscler Thromb Vasc Biol. (2015) Jan;35(1):222-8. doi: 10.1161/ATVBAHA.114.304369, Epub 2014
    PubMed link >

    Wigren M, Rattik S, Hultman K, Björkbacka H, Nordin-Fredrikson G, Bengtsson E, Hedblad B, Siegbahn A, Goncalves I, Nilsson J. Decreased levels of stem cell factor in subjects with incident coronary events. J Intern Med. (2015) Oct 14. doi: 10.1111/joim.12443.
    PubMed link >


    Cardiovascular/metabolic diseases

    2020

    Vavruch K, Nowak C, Feldreich Y, et. al. Using proximity extension proteomics assay to discover novel biomarkers associated with circulating leptin levels in patients with type 2 diabetes. (2020) Scientific Reports, DOI: 10.1038/s41598-020-69473-2
    Article link>

    2019

    Kozakova M, Morizzo C, Goncalves I, Natali A, Nilsson J and Palombo C. Cardiovascular organ damage in type 2 diabetes mellitus: the role of lipids and inflammation. (2019) Cardiovascular Diabetology, doi: /10.1186/s12933-019-0865-6
    Article link>

    2018

    Al-Talabany S, Mordi I, Houston G, Colhoun H, Weir-McCall J, Matthew S, Looker H, Levin D, Belch J, Dove F, Khan F and Lang C. Epicardial adipose tissue is related to arterial stiffness and inflammation in patients with cardiovascular disease and type 2 diabetes. (2018) BMC Cardiovascular Disorders, doi.org/10.1186/s12872-018-0770-z
    Article link>

    Kuschnerus K, Straessler E, Müller M, Lüscher T, Landmesser U and Kränkel N. Increased Expression of miR-483-3p Impairs the Vascular Response to Injury in Type 2 Diabetes. (2018) Diabetes, doi.org/10.2337/db18-0084
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    Lareyre F, Moratal C, Chikande J, Jean-Baptiste E, Hassen-Khodja R, Neels J, Chinetti G and Raffort J. Investigation of Plasma Inflammatory Profile in Diabetic Patients With Abdominal Aortic Aneurysm: A Pilot Study (2018) Vascular and Endovascular Surgery, doi:/10.1177/1538574418784717
    Article link>

    Natali A, Nesti L, Venturi E, Shore A, Khan F, Gooding K, Gates P, Looker H, Dove F, Goncalves I, Persson M and Nilsson J. Metformin is the key factor for elevated plasma GDF‐15 levels in type 2 diabetes: a nested, case‐control study. (2018) Diabetes, Obesity and Metabolism, doi.org/10.1111/dom.13519
    Article link>

    Nowak C, Carlsson A, Östgren CJ, Nyström F, Alam M, Feldreich T, Sundström J, Carrero J-J, Leppert J, Hedberg P, Henriksen E, Cordeiro A, Giedraitis V, Lind L, Inglesson E, Fall T and Ärnlöv J. Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes. (2018) Diabetologia, doi.org/10.1007/s0012
    Article link>

    Rattik S, Engelbertsen D, Wigren M, Ljungcrantz I,  Östling G, Persson M, Nordin Fredrikson G, Bengtsson E, Nilsson  J and Björkbacka H. Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease.  (2018) Diabetes and Vascular Disease Research, DOI: 10.1177/1479164118817942
    Article link>

    2017

    Yao Mattisson I, Björkbacka H, Wigren H, Edsfeldt A, Melander O, Nordin Fredrikson G, Bengtsson E, Gonçalves I, Orho-Melander M, Engström G, Almgren P and Nilsson J. Elevated Markers of Death Receptor-Activated Apoptosis are Associated with Increased Risk for Development of Diabetes and Cardiovascular Disease. (2017) EBioMedicine, doi.org/10.1016/j.ebiom.2017.11.023
    Article link>

    2016

    Goncalves I, Edsfeldt A, Colhoun H, Shore A, Palombo C, Natali A, Nordin Fredrikson G, Björbacka H, Wigren M, Bengtsson E, Östling G, Aizawa K, Casanova F, Persson M, Gooding K, Gates P, Khan F, Looker H, Adams F, Belch J, Pinnola S, Venturi E, Kozakova M, Gan L, Schnecke C and Nilsson J. Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. (2016) BMC Cardiovascular Disorders, 16:171 DOI 10.1186/s12872-016-0346-8
    Article link>

    Jahn L , Lee Hartline, Nagashree Rao, Brent Logan, Justin J Kim, Kevin Aylor , Li-Ming Gan, Helena U Westergren, and Eugene J Barrett. Insulin enhances endothelial function throughout the arterial tree in healthy but not metabolic syndrome subjects. J. Clin. Endocrinol. Metab. (2016) doi: 10.1210/jc.2015-3293
    PubMed link >

    Westergren H, Svedlund S, Momo R, Blomster J, Wåhlander K, Rehnström E, Greasley P, Regina Fritsche‑Danielson R, Oscarsson J and Gan L-M. Insulin resistance, endothelial function, angiogenic factors and clinical outcome in non‑diabetic patients with chest pain without myocardial perfusion defects. Cardiovasc Diabetol (2016) 15:36 DOI 10.1186
    Article link >

    2015

    Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, Östling G, Aizawa K, Casanova F, Persson M, Gooding K, Strain D, Kahn F, Looker HC, Adams F, Belch J, Pinnoli S, Venturi E, Kozakova M, Gan LM, Schnecke V, Nilsson J. Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. Arterioscler Thromb Vasc Biol. (2015) May 7. pii: ATVBAHA.115.305631.
    PubMed link >


    Cardiovascular/renal diseases

    2016

    Carlsson A, Sundström J, Carrero J, Gustafsson S, Stenemo M, Larsson A, Lind L and Ärnlöv J. Use of a proximity extension assay proteomics chip to discover new biomarkers associated with albuminuria. (2016) Eur J. Prev. Cardiol., DOI: 10.1177/2047487316676134.
    PubMed link>


    Cardiovascular/respiratory diseases

    2016

    Lund N, Gränsbo, K, Wernersson C and Melander O. Cardiometabolic biomarkers are predictors of readmission and death in patients hospitalized for Lacute dyspnea (2016) Am. J. Emergency Med., http://dx.doi.org/10.1016/j.ajem.2016.12.048
    Article link >

    2015

    Wiklund K, Gränsbo K, Lund N, Peyman M, Tegner L, Toni-Bengtsson M, Wiel M, Melander O. Inflammatory biomarkers predicting prognosis in patients with acute dyspnea. Am. J. Emerg. Med. (2015) doi: 10.1016/j.ajem.2015.10.052.
    PubMed link >


    Dermatological diseases

    2020

    Garshick M, Baumer Y, Dey A, et. al. Characterization of PCSK9 in the Blood and Skin of Psoriasis. (2020) Journal of Investigative Dermatology, DOI: 10.1016/j.jid.2020.05.115
    Article link>

    Garshick M, Tawil M, Barrett T, et. al. Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis Via COX-1. (2020) Arteriosclerosis, Thrombosis, and Vascular Biology, DOI: 10.1161/ATVBAHA.119.314008
    Article link>

    Rojahn T, Vorstandlechner V, Krausgruber T, et. al. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis. (2020) Journal of Allergy and Clinical Immunology, DOI: 10.1016/j.jaci.2020.03.041
    Article link>

    2019

    Bissonnette R, Maai C, Forman S, Bhatia N, Lee M, Fowler J, Tyring S, Pariser D, Sofen H, Dhawan S, Zook M, Zammit D, Usansky H, Denis L, Rao N, Song T, Pavel A and Guttman-Yassky E. (2019) The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate‐to‐severe atopic dermatitis: results from a randomized double‐blind placebo‐controlled study. British Journal of Dermatology, Doi: 10.1111/bjd.17932
    Article link>

    Brunner P, He H, Pavel A, Czarnowicki T, Lefferdink R, Erickson T, Canter T, Puar N, Rangel S, Malik K, Estrada Y, Krueger J, Guttman-Yassky E and Paller A. The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult, longstanding disease.  (2019) Journal of the American Academy of Dermatology, doi: 10.1016/j.jaad.2019.04.036
    Article link>

    He H. Li R, Choi S, Zhou L, Pavel A, Estrada Y, Krueger J and Guttman-Yassky E. Increased cardiovascular and atherosclerosis markers in blood of older atopic dermatitis patients. (2019) Annals of Allergy, Asthma & Immunology, doi: 10.1016/j.anai.2019.10.013
    Article link>

    Kragstrup T, Adams M, Lomholt S, Nielsen M, Heftdal L, Schafer P and Deleuran B. IL-12/IL-23p40 identified as a downstream target of apremilast in ex vivo models of arthritis. (2019) Therapeutic Advances in Musculoskeletal Disease, doi.org/10.1177/1759720X19828669
    Article link>

    Pavel A, Zjou L, Diaz A, Ungar B, Dan J, He H, Estrada Y, Xu H, Fernades M, Renert-Yuval, Krueger J and Guttman-Yassky E. The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature (2019) Journal of the American Association of Dermatology, doi: 10.1016/j.jaad.2019.10.039
    Article link>

    Tomalin L, Kim J, Correa da Rosa J, Lee J, Fitz L, Berstein G, Valdez H, Wolk R, Krueger J and Suárez-Fariñas M. Early quantification of systemic inflammatory-proteins predicts long-term treatment response to Tofacitinib and Etanercept: Psoriasis response predictions using blood. (2019) Journal of Investigative Dermatology, DOI: 10.1016/j.jid.2019.09.023
    Article link>

    2018

    Vossen A, van der Zee1 H, Davelaar N, Mus A, van Doorn M and Prens E. Apremilast for moderate hidradenitis suppurativa: no significant change in lesional skin inflammatory biomarkers. (2018) Journal of the European Academy of Dermatology and Venereology, doi.org/10.1111/jdv.15354
    Article link>

    2017

    Brunner P, Suárez-Fariñas M, He H, Malik K, Wen H-C, Gonzalez J, Chan T, Estrada Y, Zheng X, Khattri S, Dattola N, Krueger J and Guttman-Yassky E. The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins. (2017) Scientific Reports, DOI:10.1038/s41598-017-09207-z
    Article link>

    Kim J, Tomalin L, Lee J, Fitz L, Berstein G, Correa-da Rosa J, Garcet S, Lowes M, Valdez H, Wolk R, Suarez-Farinas M and Krueger J. Reduction of inflammatory and cardiovascular proteins in the blood of psoriasis patients; differential responses between tofacitinib and etanercept after 4 weeks of treatment. (2017) Journal of Investigative Dermatology, doi:10.1016/j.jid.2017.08.040A
    Article link>


    Developmental biology

    2018

    Lindgren K, Gülen Yaldir F, Hreinsson J, Holte J, Kårehed K, Sundström-Poromaa I, Kaihola H and Åkerud H. Differences in secretome in culture media when comparing blastocysts and arrested embryos using multiplex proximity assay. (2018) Upsala Journal of Medical Sciences, DOI:10.1080/03009734.2018.1490830
    Article link>

    2016

    Kaihola H, Yaldir F, Hreinsson J, Hörnaeus K, Bergquist J, Olivier J, Åkerud H and Sundström-Poromaa I. Effects of Fluoxetine on Human Embryo Development. (2016) Frontiers in Cellular Neuroscience, doi: /10.3389/fncel.2016.00160
    Article link >


    Endocrine disorders

    2019

    Hatziagelaki E1, Pergialiotis V2, Kannenberg JM3,4, Trakakis E, Tsiavou A, Markgraf DF, Carstensen-Kirberg M, Pacini G, Roden M, Dimitriadis G and Herder C. Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome. (2019) Exp Clin Endocrinol Diabetes, 10.1055/a-0992-9114
    Article link>

    2017

    Bergthorsdottir R, Ragnarsson O, Skrtic S, Glad K, Nilsson S, Louis Ross I, Leonsson-Zachrisson M and Johannsson G. Visceral Fat and Novel Biomarkers of Cardiovascular Disease in Patients with Addison’s Disease; a case-control study (2017) The Journal of Clinical Endocrinology & Metabolism, doi.org/10.1210/jc.2017-01324
    Article link>


    Environmental toxicology

    2019

    Alhamdow A, Lindh C, Albin M, Gustavsson P,  Tinnerberg H,  and Broberg K. Cardiovascular disease-related serum proteins in workers occupationally exposed to polycyclic aromatic hydrocarbons. (2019) Toxicological Science, doi: 10.1093/toxsci/kfz142
    Article link>

    Alhamdow A, Tinnerberg H, Lindh C, Albin M and Broberg K. Cancer-related proteins in serum are altered in workers occupationally exposed to polycyclic aromatic hydrocarbons: a cross-sectional study. (2019) Carcinogenesis, doi.org/10.1093/carcin/bgz022
    Article link>

    Gliga A, Taj T, Hedmer M, Assarsson E, Rylander L, Albin M and Broberg K. Mild steel welding is associated with alterations in circulating levels of cancer‑related proteins (2019) Archives of Toxicology.doi: 10.1007/s00204-019-02594-4
    Article link>

    Herzog J, Schmidt F, Hahad O, Hamidreza Mahmoudpour S, Mangold A, Garcia Andreo P, Prochaska J, Koeck T, Wild P, Sørensen M, Daiberi A and Münze T. Acute exposure to nocturnal train noise induces endothelial dysfunction and pro-thromboinflammatory changes of the plasma proteome in healthy subjects. (2019) Basic Research in Cardiology, DOI: 10.1007/s00395-019-0753-y
    Article link>


    Hematology

    2019

    Langer A, Leader A, Kim-Schulze S, Ginzburg Y, Merad M and Glassberg J. Inhaled steroids associated with decreased macrophage markers in nonasthmatic individuals with sickle cell disease in a randomized trial. (2019) Annals of Hematology, doi.org/10.1007/s00277-019-03635-9
    Article link>


    Hepatology

    2020

    Atabaki-Pasdar N, Ohlsson M,  Viñuela A, et. al. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. (2020) PLOS Medicine, DOI: 10.1371/journal.pmed.1003149
    Article link>

    Zhang C, Bjornson E, Arif M, et. al. The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non‐alc33oholic fatty liver disease. (2020) Molecular Systems Biology, DOI: 10.15252/msb.209495
    Article link>

    2018

    Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen M, Lundbom J, Hakkarainen A, Sirén R, Nieminen M, Lauerma K, Taskinen M-J, Mardinoglu A and Boren J. Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome. (2018) Scientific Reports, DOI:10.1038/s41598-018-31865-w
    Article link>

    Mardinoglu A , Wu H , Bjornson E , Zhang  C, Hakkarainen A , Rasanen S , Lee S , Mancina R , Bergentall  M , Pietilainen K , Soderlund  S , Matikainen N , Stahlman M , Bergh, P-O , Adiels  M , Piening B, Graner M , Lundbom N , Williams K, Romeo S , Nielsen  J , Snyder M , Uhlen M , Bergstrom G , Perkins R , Marschall H-U , Backhed F , Taskinen M-R and Boren J. An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. (2018) Cell Metabolism, doi.org/10.1016/j.cmet.2018.01.005
    Article link>


    Immunological diseases/Immunology

    2020

    Agasing A, Wu Q, Khatri B, et. al. Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica. (2020) Nature Communications, DOI: 10.1038/s41467-020-16625-7
    Article link>

    Brodin P. Technologies for assessing vaccine responses in the very young. (2020) Current Opinion in Immunology, DOI: 10.1016/j.coi.2020.03.011
    Article link>

    Carranza-León D, Oeser A, Marton A, Wang P, Gore J, Titze J, Stein C, Chung C and Ormseth M. Tissue sodium content in patients with systemic lupus erythematosus: association with disease activity and markers of inflammation. (2020) Lupus, DOI: 10.1177/0961203320908934
    Article link>

    Cirovic B, de Bree LC, Groh L, et. al. BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment. (2020) Cell Host & Microbe, DOI: 10.1016/j.chom.2020.05.014
    Article link>

    Hyland M, Mennan C, Wilson E, Clayton A and Kehoe O. Pro-Inflammatory Priming of Umbilical Cord Mesenchymal Stromal Cells Alters the Protein Cargo of Their Extracellular Vesicles. (2020) Cells, DOI: 10.3390/cells9030726
    Article link>

    Lutckii A, Strunz B, Zhirkov A, et. al.  Evidence for B cell maturation but not trained immunity in uninfected infants exposed to hepatitis C virus. (2020) Gut, DOI: 0.1136/gutjnl-2019-320269
    Article link>

    Mourtis P, Koeken V, de Bree LC, et. al. BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations. (2020) Journal of Immunological Research, DOI: 10.1155/2020/5812743
    Article link>

    Rabe T, Lazar K, Cambronero C, Goelz R and Hamprecht K. Human Cytomegalovirus (HCMV) Reactivation in the Mammary Gland Induces a Proinflammatory Cytokine Shift in Breast Milk. (2020) Microorganisms, DOI: 10.3390/microorganisms8020289
    Article link>

    van der Heijden E, Blokland S, Hillen M, et. al. Leflunomide–hydroxychloroquine combination therapy in patients with primary Sjögren’s syndrome (RepurpSS-I): a placebo-controlled, double-blinded, randomised clinical trial. (2020) The Lancet Rheumatology, DOI: 10.1016/S2665-9913(20)30057-6
    Article link>

    Zhong W, Danielsson H, Tebani A, et. al. Dramatic changes in blood protein levels during the first week of life in extremely preterm infants. (2020) Pediatric Research, DOI: 10.1038/s41390-020-0912-8
    Article link>

    2019

    Björk A, Thorlacius G, Mofors J, Richardsdotter Andersson E, Ivanchenko M, Tingström J, James T, Brokstad K, Cox R, Jonsson R, Kvarnström M and Wahren-Herlenius M. Viral antigens elicit augmented immune responses in primary Sjögren’s syndrome. (2019) Rheumatology, DOI: 10.1093/rheumatology/kez509
    Article link>

    Bränn E, Edvinsson Å, Rostedt Punga A, Sundström-Poromaa I and Skalkidou A. Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum. (2019) Scientific Reports, doi.org/10.1038/s41598-018-38304-w
    Article link>

    Goel G, Tye-Din J, Qiao S-W, Russell A, Mayassi T, Ciszewski C, Sarna V, Wang S, Goldstein K, Dzuris J, Williams L, Xavier R, Lundin K, Jabri B, Sollid L and Anderson R. Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. (2019) Science Advances, doi: 10.1126/sciadv.aaw7756
    Article link>

    Henriksson H, White R, Iliadis S, Fransson E, Papadopoulos F, Sundström-Poromaa I and Skalkidou A. Spring peaks and autumn troughs identified in peripheral inflammatory markers during the peripartum period. (2019) Scientific Reports, 10.1038/s41598-019-51527-9
    Article link>

    Ji J, Fu T, Dong C, Zhu W, Yang J, Kong X, Zhang Z, Bao Y, Zhao R, Ge X, Sha X, Lu Z, Li J and Gu Z. Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells. (2019) Aging, DOI: 10.18632/aging.102052
    Article link>

    van der Zwan M, Hesselink D, Clahsen-van Groningen M and Baan C. Targeted proteomic analysis detects acute T cell-mediated kidney allograft rejection in belatacept-treated patients. (2018) Therapeutic Drug Monitoring, doi: 10.1097/FTD.0000000000000587
    Article link>

    2018

    Bhandage A, Jin Z, Korol S, Shenb Q, Pe Y, Deng Q, Espes D, Carlsson P-O, Kamali-Moghaddamb M and Birnir B. GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4+ T Cells and Is Immunosuppressive in Type 1 Diabetes. (2018) EBioMedicine, doi.org/10.1016/j.ebiom.2018.03.019
    Article link>

    Brodin P. The biology of the cell: insights from mass cytometry. (2018) The FEBS Journal, doi: 10.1111/febs.14693
    Article link>

    Chowdhury R, Vallania F, Yang Q, Lopez Angel C, Darboe F, Penn-Nicholson A, Rozot V, Nemes E, Malherbe S, Ronacher K, Walzl G, Hanekom W, Davis M, Winter J, Chen X, Scriba T, Khatri P and Chien Y-H. A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (2018) Nature, doi: 10.1038/s41586-018-0439-x
    Article link>

    Olin A,  Henckel E, Chen Y, Lakshmikanth T, Pou C, Mikes J, Gustafsson A, Bernhardsson AK, Zhang C, Bohlin K and Brodin P. Stereotypic immune system development in newborn children. (2018) Cell, doi.org/10.1016/j.cell.2018.06.045.
    Article link>

    2017

    Lakshmikanth T, Olin A, Chen Y, Mikes J, Fredlund E, Remberger M, Omazic B and Brodin P. Mass Cytometry and Topological Data Analysis Reveal Immune Parameters Associated with Complications after Allogeneic Stem Cell Transplantation (2017) Cell Reports, doi.org/10.1016/j.celrep.2017.08.021
    Article link>

    Mrazek F, Schneiderova P, Kriegova E, Raida L, Kuba A, Gajdos P, KönigovaJana N, Onderkova J and Ambruzova Z. Profile of Inflammation-Associated Proteins in Early Post-Transplant Samples of Patients After Allogeneic Hematopoietic Stem Cell Transplantation: a Preliminary Study. (2017) Archivum Immunologiae et Therapiae Experimentalis, DOI: 10.1007/s00005-016-0446-2.
    Article link >

    Zhang W, Ambikan A, Sperk M, van Domselaar R, Nowak P, Noyan K, Russom A,, Sönnerborg A and Neogi U. Transcriptomics and Targeted Proteomics Analysis to Gain  Insights Into the Immune-control Mechanisms of HIV-1 Infected Elite Controllers. (2017) EBioMedicine, doi:10.1016/j.ebiom.2017.11.031
    Article link>


    Immunotherapy

    2020

    Babačić H,  Lehtiö J, Pico de Coaña Y, Pernemalm M and Eriksson H. In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma. (2020) Journal for ImmunoTherapy of Cancer, DOI: 10.1136/jitc-2019-000204
    Article link>

    Kasanen H, Hernberg M, Mäkelä S, Brück O, Juteau S, Kohtamäki L, Ilander M, Mustjoki S and Kreutzman A. Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients. (2020) Cancer Immunology, Immunotherapy, DOI: 10.1007/s00262-020-02497-9
    Article link>

    Pedersen JG, Madsen AT, Gammelgaard, KR, et. al.  Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors. (2020) Cancers, DOI: /10.3390/cancers12061414
    Article link>

    Reustle A, Di Marco M, Meyerhoff C, et. al. Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy. (2020) Genome Medicine, DOI: 0.1186/s13073-020-00731-8
    Article link>

    2019

    Nixon A, Schalper K, Jacobs I, Potluri S, Wang I-M and Fleener C. Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential? (2019) Journal for Immunotherapy of Cancer, DOI: 10.1186/s40425-019-0799-2
    Article link>

    Ravi D, Sarkar S, Purvey S, Passero F, Beheshti A, Chen Y, Mokhtar M, David K, Konry T and Evens A. Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural killer-cell therapy in CD20 resistant non-hodgkin lymphoma. (2019) Leukemia, DOI: 10.1038/s41375-019-0663-x
    Article link>

    Taylor M, Hughes A, Walton J, Coenen-Stass A, Magiera L, Mooney L, Bell S, Staniszewska A, Sandin L, Barry S, Watkins A, Carnealli L and Hardaker E. Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery. (2019) Journal for Immunotherapy of Cancer, DOI: 10.1186/s40425-019-0794-7
    Article link>

    2018

    Enblad G, Karlsson H, Gammelgård G, Wenthe J, Lövgren T, Amini M, Wikstrom K, Essand M, Savoldo B, Hallböök H, Höglund M, Dotti G, Brenner M, Hagberg H and Loskog A. A Phase I/IIa Trial Using CD19-Targeted ThirdGeneration CAR T Cells for Lymphoma and Leukemia. (2018) Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-18-0426
    Article link>

    2017

    Eriksson E, Milenova I, Wenthe J, Stahle M, Leja-Jarblad J, Ullenhag G, Dimberg A, Moreno R, Alemany R and Loskog A. (2017) Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus. Clinical Cancer Research, Doi: 10.1158/1078-0432.CCR-17-0285
    Article link>

    2016

    Loskog A, Maleka A, Mangsbo S, Svensson E, Lundberg C, Nilsson A, Krause J, Agnarsdottir M, Sundin A, Ahlström H, Tötterman T and Ullenhag G. Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients. British Journal of Cancer (2016) 114, 872–880. doi:10.1038/bjc.2016.42
    Article link >


    Infectious diseases

    2020

    Arunachalam P, Wimmers F, Mok C, et. al. Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans. (2020) Science, DOI: 10.1126/science.abc6261
    Article link>

    Bue M, Leth Bergholt N, Kruse Jensen L, et. al. Inflammatory proteins in infected bone tissue – An explorative porcine study. (2020) Bone Reports, DOI: 10.1016/j.bonr.2020.100292
    Article link>

    deFilippi C, Toribio M, Wong LP, et. al. Differential Plasma Protein Regulation and Statin Effects in HIV-infected and Non-HIV-infected Patients Utilizing a Proteomics Approach Protein Regulation and Statin Effects in HIV. (2020) Journal of Infectious Diseases, DOI: 0.1093/infdis/jiaa196
    Article link>

    Lopera Maya EA, van der Graaf A, Lanting P, et. al. Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes. (2020) Frontiers in Genetics, DOI: 10.3389/fgene.2020.00613
    Article link>

    Lutckii A, Strunz B, Zhirkov A, et. al.  Evidence for B cell maturation but not trained immunity in uninfected infants exposed to hepatitis C virus. (2020) Gut, DOI: 0.1136/gutjnl-2019-320269
    Article link>

    Mourtis P, Koeken V, de Bree LC, et. al. BCG-Induced Trained Immunity in Healthy Individuals: The Effect of Plasma Muramyl Dipeptide Concentrations. (2020) Journal of Immunological Research, DOI: 10.1155/2020/5812743
    Article link>

    Nelson C, Sama I, Codd V, et. al. Genetic Associations with Plasma ACE2 Concentration: Potential Relevance to COVID-19 Risk. (2020) Circulation, DOI: 10.1161/CIRCULATIONAHA.120.049007
    Article link>

    Rabe T, Lazar K, Cambronero C, Goelz R and Hamprecht K. Human Cytomegalovirus (HCMV) Reactivation in the Mammary Gland Induces a Proinflammatory Cytokine Shift in Breast Milk. (2020) Microorganisms, DOI: 10.3390/microorganisms8020289
    Article link>

    Sama I, Ravera A, Santema B, et. al. Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors. (2020) European Heart Journal, DOI: 10.1093/eurheartj/ehaa373
    Article link>

    Schmidt I, Verma A, Waikar S. Circulating plasma angiotensin-converting enzyme 2 concentrations in patients with kidney disease. (2020) European Heart Journal, DOI: 10.1093/eurheartj/ehaa523
    Article link>

    Swärd P, Edsfeldt A, Reepalu A, et. al. Age and sex differences in soluble ACE2 may give insights for COVID-19. (2020) Critical Care, DOI: 10.1186/s13054-020-02942-2
    Article link>

    Taslimi Y, Agbajogu C, Brynjolfsson SF, et. al. Profiling Inflammatory Response in Lesions of Cutaneous Leishmaniasis Patients Using a Non-Invasive Sampling Method Combined With a High-Throughput Protein Detection Assay. (2020) Cytokine, DOI: 10.1016/j.cyto.2020.155056
    Article link>

    Wang Y, Wang Y, Luo W, et. al.  A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells. (2020) International Journal of Medical Sciences, DOI: 10.7150/ijms.46695
    Article link>

    2019

    Babu H, Sperk M,Ambikan A, Rachel G, Viswanathan V, Tripathy S, Nowak P, Hanna L and Sperk U. Plasma Metabolic Signature and Abnormalities in HIV-Infected Individuals on Long-Term Successful Antiretroviral Therapy. (2019) Metabolites, doi: 10.3390/metabo9100210
    Article link>

    Klarström Engström K, Zhang B and Demirel I. Human renal fibroblasts are strong immunomobilizers during a urinary tract infection mediated by uropathogenic Escherichia coli. (2019) Scientific Reports, doi.org/10.1038/s41598-019-38691-8
    Article link>

    Lindblad A,  Persson K and Demirel I. IL-1RA is part of the inflammasome-regulated immune response in bladder epithelial cells and influences colonization of uropathogenic E. Coli  (2019) Cytokine, DOI: 10.1016/j.cyto.2019.154772
    Article link>

    Raijmakers R, Koeken V, Jansen A, Keijmel S, Roerink M, Joosten L, Netea M, van der Meer J and Bleeker-Rovers C. Cytokine profiles in patients with Q fever fatigue syndrome. (2019) Journal of Infection, doi.org/10.1016/j.jinf.2019.01.006
    Article link>

    Sun B, Fernandes N and Pulliam L. Profile of neuronal exosomes in HIV cognitive impairment exposes gender differences. (2019) AIDS, DOI: 10.1097/QAD.0000000000002272
    Article link >

    2018

    Defilippi C, Lo J, Christenson R, Grundberg I, Stone L, Zanni M, Lee H and Grinspoon S. Novel mediators of statin effects on plaque in HIV: a proteomics approach. (2018) AIDS, doi.org/10.1097/QAD.0000000000001762
    PubMed link>

    Chowdhury R, Vallania F, Yang Q, Lopez Angel C, Darboe F, Penn-Nicholson A, Rozot V, Nemes E, Malherbe S, Ronacher K, Walzl G, Hanekom W, Davis M, Winter J, Chen X, Scriba T, Khatri P and Chien Y-H. A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (2018) Nature, doi: 10.1038/s41586-018-0439-x
    Article link>

    Monaghan T, Mullish B, Patterson J, Wong G, Marchesi J, Xu H, Jilani T and Kao D. Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway. (2018) Gut Microbes, doi: 10.1080/19490976.2018.1506667
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    Sperk M, Zhang W, Nowak P and Neogi U. Plasma soluble factor following two decades prolonged suppressive antiretroviral therapy in HIV-1-positive males. (2018) Medicine, doi, 10.1097/MD.0000000000009759
    Article link>

    2017

    Cowley C, Owen A, Shiels S, Millar J,  Woolley R, Ives N, Osman H, Moss P and Bion J. Safety and Efficacy of Antiviral Therapy for Prevention of Cytomegalovirus Reactivation in Immunocompetent Critically Ill Patients.  (2017) JAMA Internal Medicine, doi:10.1001/jamainternmed.2017.0895
    Article link>

    Zhang W, Ambikan A, Sperk M, van Domselaar R, Nowak P, Noyan K, Russom A,, Sönnerborg A and Neogi U. Transcriptomics and Targeted Proteomics Analysis to Gain  Insights Into the Immune-control Mechanisms of HIV-1 Infected Elite Controllers. (2017) EBioMedicine, doi:10.1016/j.ebiom.2017.11.031
    Article link>


    Inflammatory diseases

    2020

    Björk A, Richardsdotter Andersson E, Imgenberg-Kreuz J, Thorlacius G, Mofors J, Syvänen A-C, Kvarnström M, Nordmark G and Wahren-Herlenius M. Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren’s syndrome. (2020) RMD Open, DOI: 10.1136/rmdopen-2019-000995
    Article link>

    Garshick M, Tawil M, Barrett T, et. al. Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis Via COX-1. (2020) Arteriosclerosis, Thrombosis, and Vascular Biology, DOI: 10.1161/ATVBAHA.119.314008
    Article link>

    Jodeleit H, Milchram L, Soldo R, Beikircher G, Schönthaler S, Al-amodi O, Wolf E, Beige F, Weinhäusel A, Siebeck M and Gropp R. Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis. (2020) PLOS One, DOI: 10.1371/journal.pone.0228615
    Article link>

    Majster M, Lira-Junior R, Höög C, et. al. Salivary and Serum Inflammatory Profiles Reflect Different Aspects of Inflammatory Bowel Disease Activity. (2020) Inflammatory Bowel Diseases, DOI: 10.1093/ibd/izaa190
    Article link>

    Moraes L, Magnusson M, Mavroudis G, Polster A, Jonefjäll B, Törnblom H, Sundin J, Simrén M, Strid H and Öhman P. Systemic Inflammatory Protein Profiles Distinguish Irritable Bowel Syndrome (IBS) and Ulcerative Colitis, Irrespective of Inflammation or IBS-Like Symptoms. (2020) Inflammatory Bowel Diseases, DOI: 10.1093/ibd/izz322
    Article link>

    Panezai J, Alic A, Ghaffarc A, Benchimold D, Altamasha M, Klingeb B, Engström PE and Larsson A. Upregulation of circulating inflammatory biomarkers under the influence of periodontal disease in rheumatoid arthritis patients. (2020) Cytokine, DOI: 10.1016/j.cyto.2020.155117
    Article link>

    Panezai J, Altamash M, Engstrӧm P-E and Larsson A. Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters. (2020) Journal of Diabetes Research, DOI: 10.1155/2020/6450742
    Article link>

    Perricos A, Wenzl R, Husslein H, et. al. Does the Use of the “Proseek® Multiplex Oncology I Panel” on Peritoneal Fluid Allow a Better Insight in the Pathophysiology of Endometriosis, and in Particular Deep-Infiltrating Endometriosis? (2020) Journal of Clinical Medicine, DOI: 10.3390/jcm9062009
    Article link>

    Rojahn T, Vorstandlechner V, Krausgruber T, et. al. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis. (2020) Journal of Allergy and Clinical Immunology, DOI: 10.1016/j.jaci.2020.03.041
    Article link>

    2019

    Dyskova T, Kriegova E, Slobodova Z, Zehnalova S, Kudelka M, Schneiderova P, Fillerova R and Gallo J. Inflammation time-axis in aseptic loosening of total knee arthroplasty: A preliminary study. (2019) PLOSOne, doi: 10.1371/journal.pone.0221056
    Article link>

    Ek, M, Roth B, Engström G and Ohlsson B. AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis. (2019) Int. J. Mol. Sci., doi.org/10.3390/ijms20010189
    Article link>

    Lee HS and Cleynen I. Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making? (2019) Cells, doi:10.3390/cells8060535
    Article link>

    Mavroudis G, Magnusson M, Isaksson S, Sundin J, Simrén M, Öhman L and Strid H. Mucosal and systemic immune profiles differ during early and late phase of the disease in patients with active ulcerative colitis. (2019) Journal of Crohns and Colitis, doi:10.1093/ecco-jcc/jjz072
    Article link>

    Södergren A, Bengtsson C, Möllers B, Rantapää-Dahlqvist S and Wållberg-Jonsson S. Biomarkers associated with cardiovascular disease in patients with early rheumatoid arthritis. (2019) PlosOne, doi: 10.1371/journal.pone.0220531
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    Vancamelbeke M, Laeremans T, Vanhove W, Arnauts W, Santo Ramalho A, Farré R, Cleynen I, Ferrante M and Vermeire S. Butyrate does not protect against inflammation-induced loss of c and cytokine production in primary cell monolayers from patients with ulcerative colitis. (2019) Journal of Crohns and Colitis, DOI: 10.1093/ecco-jcc/jjz064
    Article link >

    Wiberg A, Olsson-Strömberg U, Herman S, Kultima K and Burman J. Profound but Transient Changes in the Inflammatory Milieu of the Blood During Autologous Hematopoietic Stem Cell Transplantation. (2019) Biology of Blood and Marrow Transplantation, DOI: 10.1016/j.bbmt.2019.09.010
    Article link>

    Zhou H, Xi L, Ziemek D, O’Neil S, Lee J, Stewart Z, Zhan Y, Zhao S, Zhang Y, Page K, Huang A, Maciejewski M, Zhang B, Gorelick K, Fitz L, Pradhan V, Cataldi F, Vincent M, von Schack D, Hung K and Hassan-Zahraee M. Molecular Profiling of Ulcerative Colitis Subjects from the TURANDOT Trial Reveals Novel Pharmacodynamic/ Efficacy Biomarkers. (2019) Journal of Crohns and Colitis, doi.org/10.1093/ecco-jcc/jjy217
    Article link>

    2018

    Aqrawi L, Ivanchenko M, Björk A, Ramírez Sepúlveda J, Imgenberg-Kreuz J, Kvarnström M, Haselmayer P, Jensen J, Nordmark G, Chemin K, Skarstein G and Wahren-Herlenius M. Diminished CXCR5 expression in peripheral blood of patients with Sjögren’s syndrome may relate to both genotype and salivary gland homing. (2018) Clinical & Experimental  Immunology, doi: 10.1111/cei.13118
    Article link>

    Lagali N, Badian R, Liu X, Feldreich T, Ärnlöv J, Paaske Utheim T, Dahlin L and Rolandsson O. Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 9. (2018) Scientific Reports, DOI:10.1038/s41598-018-32410-5
    Article link>

    Lampinen M, Vessby J, Fredricsson A, Wanders A, Rorsman F and Carlson M. High Serum sCD40 and a Distinct Colonic T Cell Profile in Ulcerative Colitis Associated With Primary Sclerosing Cholangitis. (2018) Journal of Crohn’s and Colitis, doi.org/10.1093/ecco-jcc/jjy170
    Article link>

    Löfgren M, Svala E, Lindahl A, Skiöldebrand E and Ekman S. Time-dependent changes in gene expression induced in vitro by interleukin-1β in equine articular cartilage. (2018) Research in Veterinary Science, doi.org/10.1016/j.rvsc.2018.04.013
    Article link>

    Nuora A, Tupasela T, Jokioja J, Tahvonen R, Kallio H, Yanga B, Viitanen M and Linderborg K. The effect of heat treatments and homogenisation of cows’ milk on gastrointestinal symptoms, inflammation markers and postprandial lipid metabolism (2018) International Dairy Journal, doi.org/10.1016/j.idairyj.2018.05.017
    Article link>

    Toribio M, Fitch K, Stone L, Zanni M, Loa J, de Filippi C, Sponseller C, Lee H, Grundberg I, Thompson M, Aberg J and Grinspoon S. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. (2018) EBioMedicine, doi.org/10.1016/j.ebiom.2018.08.039
    Article link>

    2017

    Andersson E, Bergemalm D, Kruse R, Neumann G, D’Amato M, Repsilber D, and Halfvarson J. Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles. (2017) PLOS One, doi.org/10.1371/journal.pone.0186142
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    Molin C, Westerberg E and Rostedt Punga A. Profile of upregulated inflammatory proteins in sera of Myasthenia Gravis patients (2017) Scientific Reports, doi:10.1038/srep39716.
    Article link>

    Panezai J, Ghaffar A, Altamash M, Sundqvist K-G, Engström P-E and Larsson A. Correlation of serum cytokines, chemokines, growth factors and enzymes with periodontal disease parameters. (2017) PLOS ONE, doi.org/10.1371/journal.pone.0188945
    Article link>

    Petrackova A, Smrzova A, Gajdos P, Schubertova M, Schneiderova P, Kromer P, Snasel V, Skacelova M, Mrazek F, Zadrazil J, Horak P and Kriegova E. Serum protein pattern associated with organ damage and lupus nephritis in systemic lupus erythematosus revealed by PEA immunoassay. (2017) Clinical Proteomics, DOI: 10.1186/s12014-017-9167-8
    Article link>

    Savola P, Brück O, Olson T, Kelkka T, Kauppi M, Kovanen P, Kytölä S, Sokka-Isler T, Loughran T, Leirisalo-Repo M and Mustjoki S. Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. (2017) Haematologica, doi:10.3324/haematol.2017.175729
    Article link>

    Zwicker S, Lira-Junior R, Höög C, Almer S and Boström E. Systemic Chemokine Levels with “Gut-Specific” Vedolizumab in Patients with Inflammatory Bowel Disease—A Pilot Study (2017) International Journal of Molecular Sciences, doi: 10.3390/ijms18081827
    Article link>

    2016

    Berntson L, Hedlund-Treutiger I and Alving K. Anti-inflammatory effect of exclusive enteral nutrition in patients with juvenile idiopathic arthritis. (2016) Clinical and Experimental Rheumatology, 34(5):941-945
    Article link>

    2015

    Kalla R, Kennedy NA, Hjelm F, Modig E, Sundell M, Söderholm J, Andreassen B, Bergemalm D, Ventham NT, Hjortswang H, Petr R, Vatn MH, Halfvarson J, Gullberg M, Satsangi J. OC-015 Proximity extension assay technology identifies novel serum biomarkers for predicting inflammatory bowel disease: IBD character consortium. Gut (2015);64:A8 doi:10.1136/gutjnl-2015-309861.15
    Article link >


    Metabolic diseases

    2020

    Chen Z-Z and Gerszten R. Metabolomics and Proteomics in Type 2 Diabetes. (2020) Circulation Research, DOI: 10.1161/CIRCRESAHA.120.315898
    Article link>

    Dommel S, Berger C, Kunath A, et. al. The Fabp4-Cre-Model is Insufficient to Study Hoxc9 Function in Adipose Tissue. (2020) Biomedicines, DOI: 10.3390/biomedicines8070184
    Article link>

    Figarska, S, Rigdon, J, Ganna, A, et. al. Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention. (2020) Scientific Reports, DOI: 10.1038/s41598-020-64636-7
    Article link>

    Niersmann C, Röhrig K, Blüher M, Roden M, Herder C and Carstensen-Kirberg M. Proinflammatory Proteins in Primary Human Adipocytes and Activation of the Inflammatory NFĸB, p38, and ERK Pathways upon Omentin Treatment. (2020) Obesity Facts, DOI: 10.1159/000506405
    Article link>Tromp J, Voors A, Sharma A, Ferreira J, Ouwerkerk W, Hillege H, Gomez K, Dickstein K, Anker S, Metra M, Lang C, Ng L, van der Harst P, van Veldhuisen D, van der Meer P, Lam C, Zannad F and Sama I. Distinct Pathological Pathways in Patients With Heart Failure and Diabetes. (2020) JACC: Heart Failure, DOI: 10.1016/j.jchf.2019.11.005
    Article link>

    Weivoda M, Chew CK, Monroe D, Farr J, Atkinson E, Geske J, Eckhardt B, Thicke B, Ruan M, Tweed A, McCready L, Rizza R, Matveyenko A, Kassem M, Levin Andersen T, Vella A, Drake M, Clarke B, Oursler MJ and Khosla S. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. (2020) Nature Communications, DOI: 10.1038/s41467-019-14003-6
    Article link>

    Wu S, Noren Hooten N, Freeman, et. al. Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration. (2020) Journal of Translational Medicine, DOI: 10.1186/s12967-020-02398-6
    Article link>

    2019

    Beijer K, Nowak C, Sundström J, Ärnlöv J, Fall T and Lind L. In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study. (2019) Diabetologia, doi: 10.1007/s00125-019-4960-8
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    Jokioja J, Linderborg Kortesniemi M, Nuora A, Heinonen J, Sainio T, Viitanen M, Kallio H and Yang B. Anthocyanin-rich extract from purple potatoes decreases postprandial glycemic response and affects inflammation markers in healthy men. (2019) Food Chemistry, DOI: 10.1016/j.foodchem.2019.125797
    Article link>

    Li Z, Rasmussen T, Rasmussen M, Li J, Henríquez Olguín C, Kot W, Nielsen D and Jensen T. The Gut Microbiome on a Periodized Low-Protein Diet Is Associated With Improved Metabolic Health.  (2019) Frontiers in microbiology, DOI: 10.3389/fmicb.2019.00709
    Article link>

    Lind L, Elmståhl S and Ingelsson E. Cardiometabolic Proteins Associated with Metabolic Syndrome.  (2019) Metabolic Syndrome and Related Disorders, doi.org/10.1089/met.2018.0123
    Article link>

    Lind L, Figarska S, Sundström J, Fall T, Ärnlöv J and Inglesson E. Changes in Proteomic Profiles are Related to Changes in BMI and Fat Distribution During 10 Years of Aging. (2019) Obesity, DOI: 10.1002/oby.22660
    Article link>

    Molvin J, Pareek M, Jujic A, Melander O, Råstam L, Lindblad U, Daka B, Leósdóttir M, Nilsson P, Olsen M and Magnusson M. Using a Targeted Proteomics Chip to Explore Pathophysiological Pathways for Incident Diabetes– The Malmö Preventive Project. (2019) Scientific Reports,  DOI:10.1038/s41598-018-36512-y
    Article link>

    Muhammad I, Borné Y, Bao X, Melander O, Orho-Melander M, Nilsson P, Nilsson J and Engström G. Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study. (2019) Diabetes Care, doi: 10.2337/dc18-2556
    Article link >

    Niewczas M, Pavkov M, Skupien J, Smiles A, Dom Z, Wilson J, Park J, Nair V, Schlafly A, Saulnier P-J, Satake E, Simeone C, Shah H, Qiu C, Looker H, Fiorina P, Ware C, Sun J, Doria A, Kretzler M, Susztak K, Duffin K, Nelson R and Krolewski A. A Signature of Circulating Inflammatory Proteins Enriched for TNF Receptor Superfamily and High Risk of ESRD in Diabetes.  (2019) Nature Medicine, doi.org/10.1038/s41591-019-0415-5
    Article link>

    Rajan M, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton N, Biörserud C, Lindahl T, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman J, Perkins R, Wallenius V, Lange S and Börgeson E. Comparative analysis of obesity related cardiometabolic and renal biomarkers in human plasma and serum. (2019) Scientific Reports, DOI: 10.1038/s41598-019-51673-0
    Article link>

    Reiche M, den Toom M, Willemsen L, van Os B, Gijbels M, Gerdes N, Aarts S and Lutgens E. Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction. (2019) BMJ Open Diabetes Research and Care, DOI: 10.1136/bmjdrc-2019-000829
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    Ziegler D, Strom A, Bönhof G, Kannenberg J, Heier M, Rathman W, Peters A, Meisinger C, Roden M, Thorand B and Herder C. Deficits in systemic biomarkers of neuroinflammation and growth factors promoting nerve regeneration in patients with type 2 diabetes and polyneuropathy. (2019) BMJ Open Diabetes Research & Care. DOI: 10.1136/bmjdrc-2019-000752
    Article link>

    2018

    Bao X, Borné Y, Faqir Muhammad I, Nilsson J, Lind L, Melander O, Niu K, Orho-Melander M and Engström G. Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer–Cardiovascular Cohort (2018)  Diabetologia, DOI/10.1007/s00125-018-4751-7
    Article link>

    Dencker M, Arvidsson D, Karlsson M, Wollmer P, Andersen L and Thorsson O. Galectin-3 levels relate in children to total body fat, abdominal fat, body fat distribution, and cardiac size (2018) European J. Paediatrics, doi: 10.1007/s00431-017-3079-5
    Article link>

    Fernandez C, Rysä J, Almgren P, Nilsson J, Engström G, Orho‐Melander M, Ruskoaho H and Melander O. Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality. (2018) Journal of Internal Medicine, doi.org/10.1111/joim.12783
    Article link>

    Lagali N, Badian R, Liu X, Feldreich T, Ärnlöv J, Paaske Utheim T, Dahlin L and Rolandsson O. Dendritic cell maturation in the corneal epithelium with onset of type 2 diabetes is associated with tumor necrosis factor receptor superfamily member 9. (2018) Scientific Reports, DOI:10.1038/s41598-018-32410-5
    Article link>

    Piening B, Zhou W, Contrepois K, Röst H, Urban G, Mishra T, Hanson B, Bautista E, Leopold S, Yeh C, Spakowicz D, Banerjee I, Chen C, Kukurba K, Perelman D, Craig C, Colbert E, Salins D, Rego S, Lee S, Zhang C, Wheeler J, Sailani R, Liang L, Abbott C, Gerstein M, Mardinoglu A, Smith U, Rubin D, Pitteri S, Sodergren E, McLaughlin T, Weinstock G and Snyder M. Integrative Personal Omics Profiles during Periods of Weight Gain and Loss (2018) Cell Systems, doi.org/10.1016/j.cels.2017.12.013
    Article link>

    Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen M, Lundbom J, Hakkarainen A, Sirén R, Nieminen M, Lauerma K, Taskinen M-J, Mardinoglu A and Boren J. Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome. (2018) Scientific Reports, DOI:10.1038/s41598-018-31865-w
    Article link>

    Schlesinger S, Herder C, Kannenberg J, Huth C, Carstensen-Kirberg M, Rathmann W, Bönhof G, Koenig W, Heier M, Peters A, Meisinger C, Roden M, Thorand B and Ziegler D. General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort. (2018) Diabetes Care, doi.org/10.2337/dc18-1842
    Article link>

    Shah R, Hwang S-J, Yero A, Tanriverdi K, Pico A, Yao C, Murthy V, Ho J, Vitseva O, Demarco D, Shah S, Iafrati M, Levy D and Freedman J. Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community. (2018) Arteriosclerosis, Thrombosis, and Vascular Biology, doi/abs/10.1161/ATVBAHA.118.311928
    Article link>

    2017

    Dencker M, Danielson A, Karlsson M, Wollmer P, Andersen L and Thorsson O. Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children. (2017) Journal of Pediatric Endocrinology and Metabolism, https://doi.org/10.1515/jpem-2016-0278.
    Article link >

    Harlid S, Myte R and Van Guelpen B. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. (2017) Mediators of Inflammation, doi:10.1155/2017/4803156
    Article link>

    2015

    Nowak C, Sundström J, Gustafsson S, Giedraitis V, Lind L, Ingelsson E, Fall T.Protein biomarkers for insulin resistance and type 2 diabetes risk in two large community cohorts. Diabetes. (2015) Sep 29. pii: db150881.
    PubMed link >


    Nephrology

    2020

    Edfors R, Lindhagen L, Spaak J, et. al. Use of proteomics to identify biomarkers associated with chronic kidney disease and long‐term outcomes in patients with myocardial infarction. (2020) Journal of Internal Medicine, DOI: 10.1111/joim.13116
    Article link>

    von Moos S, Segerer S, Davenport A, Sadoune M, Gerritsen K, Pottecher J, Ruschitzka F, Mebazaa A, Arrigo M and Cippà P. Vascular endothelial growth factor D is a biomarker of fluid overload in haemodialysis patients. (2020) Nephrology Dialysis Transplantation, DOI: 10.1093/ndt/gfz281
    Article link>

    Wu P-H, Lin Y-T, Wu P-Y, Lee H-H, Lee S-C, Hung S-C, Chen S-C, Kuo M-C and Chiu Y-W. Association between Circulation Indole-3-Acetic Acid Levels and Stem Cell Factor in Maintenance Hemodialysis Patients: A Cross-Sectional Study. (2020) Journal of Clinical Medicine, DOI: 10.3390/jcm9010124
    Article link>

    2019

    Fellström B, Helmersson-Karlqvist J, Lind , Soveri I, Wu P-H, Thulin M, Ärnlöv J and Larsson A. Associations Between Apolipoprotein A1, High-Density Lipoprotein Cholesterol, and Urinary Cytokine Levels in Elderly Males and Females. (2019) Journal of Interferon & Cytokine Research, doi: 10.1089/jir.2019.0074
    Article link>

    Schulz C-A, Engström G, Nilsson G, Almgren P, Petkovic M, Christensson A, Nilsson P, Melander O and Orho-Melander M. Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years. (2019)  Nephrology Dialysis Transplantation, doi/10.1093/ndt/gfy382/5284694
    Article link>

    Niewczas M, Pavkov M, Skupien J, Smiles A, Dom Z, Wilson J, Park J, Nair V, Schlafly A, Saulnier P-J, Satake E, Simeone C, Shah H, Qiu C, Looker H, Fiorina P, Ware C, Sun J, Doria A, Kretzler M, Susztak K, Duffin K, Nelson R and Krolewski A. A Signature of Circulating Inflammatory Proteins Enriched for TNF Receptor Superfamily and High Risk of ESRD in Diabetes.  (2019) Nature Medicine, doi.org/10.1038/s41591-019-0415-5
    Article link>

    van der Zwan M, Hesselink D, Clahsen-van Groningen M and Baan C. Targeted proteomic analysis detects acute T cell-mediated kidney allograft rejection in belatacept-treated patients. (2018) Therapeutic Drug Monitoring, doi: 10.1097/FTD.0000000000000587
    Article link>

    Wu P-H, Chiu Y-W, Zou H-B, Lee S-C, Lin Y-T, Tsai Y-T, Kuo M-C and Hwang S-J. Exploring the Benefit of 2-Methylbutyric Acid in Patients Undergoing Hemodialysis Using a Cardiovascular Proteomics Approach. (2019) Nutrition, DOI: 10.3390/nu11123033
    Article link>

    2018

    Cañadas-Garre M, Anderson K, McGoldrick J, Maxwell A and McKnight A. Proteomic and metabolomic approaches in the search for biomarkers in chronic kidney disease. (2018) Journal of Proteomics, doi:10.1016/j.jprot.2018.09.020
    Article link>

    Feldreich T, Nowak C, Fall T, Carlsson A, Carrero J-J, Ripsweden J, Qureshi AR, Heimbürger O, Barany P, Stenvinke P, Vuilleumier N, Kalra P, Green D and Ärnlöv J. Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease. (2018) Journal of Nephrology, doi: 10.1007/s40620-018-0556-5
    Article link>

    Sällman Almén M, Björk J, Nyman U, Lindström V, Jonsson M, Abrahamson M, Schiller Vestergren A, Lindhe Ö, Franklin G, Christensson A and Grubb A. Shrunken pore syndrome is associated with increased levels of atherosclerosis promoting proteins. (2018) Kidney International Reports, doi.org/10.1016/j.ekir.2018.09.002.
    Article link>

    2017

    Carlsson A, Ingelsson E, Sundström J, Carrero J, Gustafsson S, Feldreich T, Stenemo M, Larsson A, Lind L and Ämlöv J.Use of Proteomics To Investigate Kidney Function Decline over 5 Years. Clinical Journal of the American Society of Nephrology (2017), doi: 10.2215/CJN.08780816
    Article link>


    Neurology

    2020

    Agasing A, Wu Q, Khatri B, et. al. Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica. (2020) Nature Communications, DOI: 10.1038/s41467-020-16625-7
    Article link>

    Begum G, Reddy R, Yakoub K, Belli A, Davies D and Di Pietro V. Differential Expression of Circulating Inflammatory Proteins Following Sport-Related Traumatic Brain Injury. (2020) International Journal of Medical Sciences, DOI: 10.3390/ijms21041216
    Article link>

    Bergman J, Svenningsson A, Liv P, et. al. Location matters: highly divergent protein levels in samples from different CNS compartments in a clinical trial of rituximab for progressive MS. (2020) Fluids Barriers CNS, DOI: 10.1186/s12987-020-00205-4
    Article link>

    Danielson M, Wiklund A, Granath F, Blennow K, Mkrtchian S, Nellgård B, Oras J, Jonsson Fagerlund M, Granström A, Schening A, Rasmussen L, Erlandsson Harris H, Zetterberg H, Zetterberg S-E and Eriksson L. Neuroinflammatory markers associate with cognitive decline after major surgery: findings of an explorative study. (2020) Annals of Neurology, DOI: 10.1002/ana.25678
    Article link>

    Ghai V, Fallen S, Baxter D, Scherler K, Kim T-K, Zhou Y, Meabon J, Logsdon A, Banks WA, Schindler A, Cook D, Peskinf E, Lee I and Wang K. Alterations in plasma microRNA and protein levels in war veterans with chronic mild traumatic brain injury. (2020) Journal of Neurotrauma, DOI: 10.1089/neu.2019.6826
    Article link>

    Harris S, Cox S, Bell S, Marioni R, Prons B, Pattie A, Corley J, Muñoz Maniega S, Valdés Hernández M, Morris Z, John S, Bronson P, Tucker-Drob E, Starr J, Bastin M, Wardlaw J, Butterworth A and Deary I. Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age. (2020) Nature Communications, DOI: /10.1038/s41467-019-14161-7
    Article link>

    Huang J, Khademi M, Fugger L, et. al. Inflammation-related plasma and CSF biomarkers for multiple sclerosis. (2020) PNAS, DOI: 10.1073/pnas.1912839117
    Article link>

    Jonsjö M, Olsson G, Wicksell R, Alving K, Holmström L and Andreasson A. The role of low-grade inflammation in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) – associations with symptoms. (2020) Psychoneuroendocrinology, DOI: 10.1016/j.psyneuen.2019.104578
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    Kuan P-F, Clouston S, Yang X, et. al. Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders. (2020) Translational Psychiatry, DOI: 10.1038/s41398-020-00958-4
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    Ljunggren M, Theorell-Haglöw J, Freyhult E, Sahlin C, Franklin K, Malinovschi A, Janson C and Lindberg E. Association between proteomics and obstructive sleep apnea phenotypes in a community‐based cohort of women. (2020) Journal of Sleep Research, DOI: 10.1111/jsr.13041
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    Nilsson I, Millischer V, Göteson A, Hübel C, Thornton L, Bulik C, Shalling M and Landén M. Aberrant inflammatory profile in acute but not recovered anorexia nervosa. (2020) Brain, Behavior and Immunity, DOI: 10.1016/j.bbi.2020.05.024
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    Santaella A, Kuiperij HB, van Rumund A, Esselink R, van Gool A, Bloem B and Verbeek  M. Inflammation biomarker discovery in Parkinson’s disease and atypical parkinsonisms. (2020) BMC Neurology, DOI: 10.1186/s12883-020-1608-8
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    Saxena S, Lokhande H, Gombolay G, et. al. dentification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases. (2020) Scientific Reports, DOI: 10.1038/s41598-020-69182-w
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    2019

    Carlström K, Ewing E, Granqvist M, Gyllenberg A, Aeinehband S, Lind Enoksson S, Checa A, Badam T, Huang J, Gomez-Cabrero D, Gustafsson M, Al Nimer F, Wheelock C, Kockum I, Olsson T, Jagodic M and Pieh F. Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes. (2019) Nature Communications, doi: /10.1038/s41467-019-11139-3
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    Dyhrfort P, Shen Q, Clausen F, Thulin M, Enblad P, Kamali-Moghaddam M, Hillered L and Lewén A. Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care. (2019) Journal of Neurotrauma, doi.org/10.1089/neu.2018.6320
    Article link>

    Hillary R, Stevenson A, Cox S, et. al. An epigenetic predictor of death captures multi-modal measures of brain health. (2019) Molecular Psychiatry, DOI: 10.1038/s41380-019-0616-9
    Article link>

    Hysing E-H, Smith L, Thulin M, Karlsten R, Bothelius K and Gordh T. Detection of systemic inflammation in severely impaired chronic pain patients and effects of a multimodal pain rehabilitation program. (2019) Scandinavian Journal of Pain, DOI: 10.1515/sjpain-2018-0340
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    Jabbari E, Woodside J, Guo T, Magdalinou N, Chelban V, Athauda D, Lees A, Foltynie T, Houlden H, Church A, Hu M, Rowe J, Zetterberg H and Morris H. Proximity extension assay testing reveals novel diagnostic biomarkers of atypical parkinsonian syndromes (2019) J Neurol Neurosurg Psychiatry, doi: 10.1136/jnnp-2018-320151
    Article link>

    Pulliam L, Sun B, Mustapic M, Chawla S and Kapogiannis D. Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease. (2019) Journal of NeuroVirology,  doi: 10.1007/s13365-018-0695-4
    Article link>

    Sun B, Fernandes N and Pulliam L. Profile of neuronal exosomes in HIV cognitive impairment exposes gender differences. (2019) AIDS, DOI: 10.1097/QAD.0000000000002272
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    Sundberg I, Rasmusson A, Ramklint M, Just D, Ekselius L and Cunningham J. Daytime Melatonin Levels in Saliva are Associated with Inflammatory Markers and Anxiety Disorders. (2019) Psychoneuroendocrinology, DOI: 10.1016/j.psyneuen.2019.104514
    Article link>

    van Ton A, Verbeek M, Alkema W, Pickkers P and Abdo W.  Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer’s disease. (2020) Brain, Behavior and Immunity, DOI: 10.1016/j.bbi.2020.06.027
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    Wang H, Davison M, Wang K, Xia T-H, Kramer M, Call K, Luo J, Wu X, Zuccarino R, Bacon C, Bai Y, Moran J, Gutmann L, Feely S, Grider T, Rossor A, Reilly M, Svaren J and Shy M. Transmembrane protease serine 5: a novel Schwann cell plasma marker for CMT1A. (2019) Annals of Clinical & Translational Neurology, DOI: 10.1002/acn3.50965
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    Whelan C, Mattsson N, Nagle M, Vijayaraghavan S, Hyde C, Janelidze S, Stomrud E, Lee J, Fitz L, Samad T, Ramaswamy G, Margolin R, Mälarstig A and Hansson O. Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease. (2019) Acta Neuropathologica Communications, DOI: 10.1186/s40478-019-0795-2
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    Wiberg A, Olsson-Strömberg U, Herman S, Kultima K and Burman J. Profound but Transient Changes in the Inflammatory Milieu of the Blood During Autologous Hematopoietic Stem Cell Transplantation. (2019) Biology of Blood and Marrow Transplantation, DOI: 10.1016/j.bbmt.2019.09.010
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    Ziegler D, Strom A, Bönhof G, Kannenberg J, Heier M, Rathman W, Peters A, Meisinger C, Roden M, Thorand B and Herder C. Deficits in systemic biomarkers of neuroinflammation and growth factors promoting nerve regeneration in patients with type 2 diabetes and polyneuropathy. (2019) BMJ Open Diabetes Research & Care. DOI: 10.1136/bmjdrc-2019-000752
    Article link>

    2018

    Bränn E, Fransson E, White R, Papadopoulos F, Edvinsson Å, Kamali‐Moghaddam M, Cunningham J, Sundström‐Poromaa I and Skalkidou  A. Inflammatory markers in women with postpartum depressive symptoms (2018) Journal of Neuroscience Research, doi.org/10.1002/jnr.24312
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    Carlyle B, Trombetta B and Arnold S. Proteomic Approaches for the Discovery of Biofluid Biomarkers of Neurodegenerative Dementias (2018) Proteomes, doi:10.3390/proteomes6030032
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    Di Pietro V, Porto E, Ragusa M, Barbagallo C, Davies D, Forcione M, Logan A, Di Pietro C, Purrello M, Grey M, Hammond D, Sawlani V, Barbey A and Belli A. Salivary microRNAs: diagnostic markers of mild traumatic brain injury in contact-sport. (2018) Frontiers in Molecular Neuroscience, doi.org/10.3389/fnmol.2018.00290
    Article link>

    Edvinsson Å, Bränn E,  Hellgren C, Freyhult E, White R, Kamali-Moghaddam M, Olivier J, Bergquist J, Boström A, Schiöth H, Skalkidou A, Cunningham J and Sundström-Poroma  I. Lower inflammatory markers in women with antenatal depression brings the M1/M2 balance into focus from a new direction. (2018) Psychoneuroendocrinology, doi: 10.1016/j.psyneuen.2017.02.027
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    Herder C, Kannenberg J, Carstensen-Kirberg M, Strom A, Bönhof G, Rathmann W, Huth C, Koenig W, Heier M, Krumsiek J, Peters A, Meisinger C, Roden M, Thorand B and Ziegler D. A Systemic Inflammatory Signature Reflecting Crosstalk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4/FF4 Study (2018) Diabetes, doi: 10.2337/db18-0060
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    Lagerstedt L, Egea-Guerrero J, Rodríguez-Rodríguez A, Bustamante A, Montaner J, El Rahal A, Andereggen R, Rinaldi L, Sarrafzadeh A, Schaller K and Sanchez J-C. Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury. (2018) PLOS ONE, doi.org/10.1371/journal.pone.0193278
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    Schlesinger S, Herder C, Kannenberg J, Huth C, Carstensen-Kirberg M, Rathmann W, Bönhof G, Koenig W, Heier M, Peters A, Meisinger C, Roden M, Thorand B and Ziegler D. General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort. (2018) Diabetes Care, doi.org/10.2337/dc18-1842
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    Solheim N, Gregersen I, Halvorsen B, Bjerkeli V, Stubhaug A, Gordh T and Rosseland L. Randomized controlled trial of intra-articular ketorolac on pain and inflammation after minor arthroscopic knee surgery. (2018) Acta Anaesthesiologica Scandinavica, doi:10.3390/ijms18122697
    Article link>

    2017

    Bränn E, Papadopoulos F, Fransson E, White R, Edvinsson Å, Hellgren C, Kamali-Moghaddam M, Boström A, Schiöth H, Sundström-Poromaa H and Skalkidou A. Inflammatory markers in late pregnancy in association withpostpartum depression—A nested case-control study (2017) Psychoneuroendocrinology, doi.org/10.1016/j.psyneuen.2017.02.029
    Article link>

    Bäckryd E, Lind A-L, Thulin M,  Larsson A, Gerdle B and Gordh T. High levels of cerebrospinal fluid chemokines point to the presence of neuroinflammation in peripheral neuropathic pain: a cross-sectional study of 2 cohorts of patients compared with healthy controls. (2017) Pain, doi:10.1097/j.pain.0000000000001061
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    Bäckryd E, Tanum L, Lind A-L, Larsson A and Gordh T. Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma. (2017) Journal of Pain Research, https://doi.org/10.2147/JPR.S128508
    Article link>

    Dencker M, Björgell O and Hlebowicz J. Effect of food intake on 92 neurological biomarkers in plasma. (2017) Brain and Behaviour, DOI: 10.1002/brb3.747.
    Article link>

    Gerdle B, Ghafouri B, Ghafouri N, Bäckryd E and Gordh T. Signs of ongoing inflammation in female patients with chronic widespread pain. A multivariate, explorative, cross-sectional study of blood samples. (2017) Medicine, http://dx.doi.org/10.1097/MD.0000000000006130
    Article link>

    Hill L, Di Pietro V, Hazeldine J, Davies D, Tomman E, Logan A and Belli A. Cystatin D (CST5): An ultraearly inflammatory biomarker of traumatic brain injury. (2017)  Scientific Reports, DOI:10.1038/s41598-017-04722-5
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    Solheim N, Östlund, S, Gordh T and Rosseland L.A. Women report higher pain intensity at a lower level of inflammation after knee surgery compared with men. (2017) Pain Reports, doi: 10.1097/PR9.0000000000000595
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    Stensson N, Ghafouri B, Gerdle B and Ghafouri N. Alterations of anti-inflammatory lipids in plasma from women with chronic widespread pain – a case control study (2017) Lipids in Health &  Disease, DOI: 10.1186/s12944-017-0505-7
    Article link>

    2016

    Andreasson U, Blennow K and Zetterberg H. Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders. Alzheimer’s & Dementia (2016), 3, 98-102.
    Article link>

    Moen A, Lind A-L, Thulin M, Kamali-Moghaddam M, Røe C, Gjerstad J and Gordh T. Inflammatory serum protein profiling of patients with lumbar radicular pain one year after disc herniation. Int. J. Inflammation (2016) Article ID 3874964.
    Article link >

    2015

    Isgren A, Jakobsson J, Pålsson E, Ekman C J, Johansson A G.M., Sellgren C, Blennow K, Zetterberg H and Landén M. Increased cerebrospinal fluid interleukin-8 in bipolar disorder patients associated with lithium and antipsychotic treatment. Brain Behav Immun. (2015) Jan;43:198-204. doi: 10.1016/j.bbi.2014.10.001.
    PubMed link >

    Miclescu AA, Svahn M, Gordh TE. Evaluation of the protein biomarkers and the analgesic response to systemic methylene blue in patients with refractory neuropathic pain: a double-blind, controlled study. J Pain Res. (2015) Jul 15;8:387-97. doi: 10.2147/JPR.S84685. eCollection 2015.
    PubMed link >

    2014

    Hillered L, Dahlin AP, Clausen F, Chu J, Bergquist J, Hjort K, Per Enblad P and Lewén A. Cerebral microdialysis for protein biomarker monitoring in the neurointensive care setting – a technical approach. Front Neurol. (2014); 5: 245.
    PubMed link >


    Neurovascular disease

    2019

    Lee M-J, Fallen S, Zhou Y, Baxter D, Scherler K, Kuo M-F and Wang K. The Impact of Moyamoya Disease and RNF213 Mutations on the Spectrum of Plasma Protein and MicroRNA. (2019) Journal of Clinical Medicine, doi: 10.3390/jcm8101648
    Article link>

    2018

    Tewari S, Renney G, Brewin J, Gardner K, Kirkham F, Inusa B, Barrett J, Menzel S, Thein S-L, Ward M and Rees D. Proteomic Analysis Of Plasma From Children With Sickle Cell Anemia And Silent Cerebral Infarction (2018) Haematolgica, Doi:10.3324/haematol.2018.187815
    Article link>


    Nutritional science

    2019

    Jokioja J, Linderborg Kortesniemi M, Nuora A, Heinonen J, Sainio T, Viitanen M, Kallio H and Yang B. Anthocyanin-rich extract from purple potatoes decreases postprandial glycemic response and affects inflammation markers in healthy men. (2019) Food Chemistry, DOI: 10.1016/j.foodchem.2019.125797
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    Kuang A, Erlund I, Herder C, Westerhuis J, Tuomilehto J and Cornelis M. Targeted proteomic response to coffee consumption. (2019) European Journal of Nutrition, doi: 10.1007/s00394-019-02009-1
    Article link>

    Lemming E, Byberg L, Stattin K, Ahmad S, Lind L, Elmståhl S, Larsson S, Wolk A and Michaëlsson K. Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross‐Sectional Study in 2 Independent Cohorts. (2019) Journal of the American Heart Association, doi: 10.1161/JAHA.118.011860
    Article link >

    Obstetrics

    2019

    Henriksson H, White R, Iliadis S, Fransson E, Papadopoulos F, Sundström-Poromaa I and Skalkidou A. Spring peaks and autumn troughs identified in peripheral inflammatory markers during the peripartum period. (2019) Scientific Reports, 10.1038/s41598-019-51527-9
    Article link>

    Oncology

    2020

    Ali, A.S., Perren, A., Lindskog, C. et. al. Candidate protein biomarkers in pancreatic neuroendocrine neoplasms grade 3. (2020) Scientific Reports, DOI: /10.1038/s41598-020-67670-7
    Article link>

    Babačić H,  Lehtiö J, Pico de Coaña Y, Pernemalm M and Eriksson H. In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma. (2020) Journal for ImmunoTherapy of Cancer, DOI: 10.1136/jitc-2019-000204
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    Johansson P, Krona C, Kundu S, et. al. A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma. (2020) Cell Reports, DOI: 10.1016/j.celrep.2020.107897
    Article link>

    Kasanen H, Hernberg M, Mäkelä S, Brück O, Juteau S, Kohtamäki L, Ilander M, Mustjoki S and Kreutzman A. Age-associated changes in the immune system may influence the response to anti-PD1 therapy in metastatic melanoma patients. (2020) Cancer Immunology, Immunotherapy, DOI: 10.1007/s00262-020-02497-9
    Article link>

    Landin D, Ährlund-Richter A, Mirzaie L, et. al. Immune related proteins and tumor infiltrating CD8 + lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV ) and clinical outcome. (2020) Head & Neck, DOI: 10.1002/hed.26364
    Article link>

    Pedersen JG, Madsen AT, Gammelgaard, KR, et. al.  Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors. (2020) Cancers, DOI: /10.3390/cancers12061414
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    Reustle A, Di Marco M, Meyerhoff C, et. al. Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy. (2020) Genome Medicine, DOI: 0.1186/s13073-020-00731-8
    Article link>

    Söderlund S, Persson I, Ilander M, Guilhot J, Hjorth-Hansen H, Koskenvesa P, Richter J, Saussele S, Mustjoki S and Olsson-Strömberg U. Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy. (2020) Leukemia Research, DOI: 10.1016/j.leukres.2020.106310
    Article link>

    Tromp J, Boerman L, Sama I, Maass S, Maduro J, Hummel Y, Berger M, de Bock G, Gietema J, Berendsen A and van der Meer P. Longterm survivors of early breast cancer treated with chemotherapy are characterized by a proinflammatory biomarker profile compared to matched controls (2020) European Journal of Heart Failure, DOI: 10.1002/ejhf.1758
    Article link>

    2019

    Alhamdow A, Tinnerberg H, Lindh C, Albin M and Broberg K. Cancer-related proteins in serum are altered in workers occupationally exposed to polycyclic aromatic hydrocarbons: a cross-sectional study. (2019) Carcinogenesis, doi.org/10.1093/carcin/bgz022
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    Berggrund M, Enroth S, Lundberg M, Assarsson E, Stålberg K, Lindquist D, Hallmans G, Grankvist K, Olovsson M and Gyllensten U. Identification of candidate plasma protein biomarkers for cervical cancer using the multiplex proximity extension assay. (2019) Molecular and Cellular Proteomics, doi.org/10.1074/mcp.RA118.001208
    Article link>

    Bhardwaj M, Gies A, Weigl K, Tikk K, Benner A, Schrotz-King P, Borchers C and Brenner H. Evaluation and Validation of Plasma Proteins Using Two Different Protein Detection Methods for Early Detection of Colorectal Cancer. (2019) Cancers, doi: 10.3390/cancers11101426
    Article link>

    Björkman K, Mustonen H, Kaprio T, Haglund C and Böckelman C. Mucin 16 and kallikrein 13 as potential prognostic factors in colon cancer: Results of an oncological 92-multiplex immunoassay. (2019) Tumor Biology, doi 10.1177/1010428319860728
    Article link >

    Chandran V, Welinder C, Månsson A-S, Offer S, Freyhult E, Pernemalm M, Lund S, Pedersen S, Lehtiö J, Marko-Varga G, Johansson M, Englund E, Sundgren P and Beltin M. Ultrasensitive immunoprofiling of plasma extracellular vesicles identifies syndecan-1 as a potential tool for minimally invasive diagnosis of glioma. (2019) Clinical Cancer Research, DOI: 10.1158/1078-0432.CCR-18-2946
    Article link>

    Dencker M,  Björgell O and Hlebowicz J. Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel.  (2019) BMC Research Notes, doi.org/10.1186/s13104-019-4237-9
    Article link>

    Djureinovic D, Pontén V, Landelius P, Al Sayegh S, Kappert K, Kamali-Moghaddam M, Micke P and Ståhle E. (2019) Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung. BMC Cancer, Doi: 10.1186/s12885-019-5943-3
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    Dubbelboer I, Pavlovic N, Heindryckx F, Sjögren E and Lennernäs H. (2019) Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile. Cancers, Doi: 10.3390/cancers11071024
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    Enroth S, Berggrund M, Lycke M, Broberg J, Lundberg M, Assarsson E, Olovsson M, Stålberg K, Sundfeldt K and Gyllensten U. High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancer. (2019) Communications Biology, doi: 10.1038/s42003-019-0464-9
    Article link>

    Finkernagel F, Reinartz S, Schuldner M, Malz A, Jansen J, Wagner M, Worzfeld T, Graumann J, von Strandmann EP and Müller R. Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. (2019) Theranostics, DOI: 10.7150/thno.37549
    Article link>

    Gliga A, Taj T, Hedmer M, Assarsson E, Rylander L, Albin M and Broberg K. Mild steel welding is associated with alterations in circulating levels of cancer‑related proteins (2019) Archives of Toxicology.doi: 10.1007/s00204-019-02594-4
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    Graumann J, Finkernagel F, Reinartz S, Stief T, Brödje D, Renz H, Jansen J, Wagner U, Worzfeld T, Pogge von Strandmann E and Mülle R. Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma. (2019) Frontiers in Oncology, DOI: 10.3389/fonc.2019.01150
    Article link>

    Kreutzman A, Yadav B, Brummendorf T, Gjertsen B-T, Lee M, Janssen J, Kasanen T, Koskenvesa P, Lotfi K, Markevärn B, Olsson-Strömberg U, Stentoft J, Stenke L, Söderlund S, Udby L, Richter J, Hjorth-Hansen H Mustjoki S. (2019) Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line. OncoImmunology, Doi: 10.1080/2162402X.2019.1638210
    Article link>

    Lindahl G, Abrahamsson A and Dabrosin C. Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women. (2019) European Journal of Clinical Nutrition, doi: 10.1038/s41430-019-0396-y
    Article link>

    Muinau T, Prasanna H Boruah H and  Pal M. Multi-biomarker panel signature as the key to diagnosis of ovarian cancer. (2019) Heliyon, DOI: 10.1016/j.heliyon.2019.e02826
    Article link>

    Nixon A, Schalper K, Jacobs I, Potluri S, Wang I-M and Fleener C. Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential? (2019) Journal for Immunotherapy of Cancer, DOI: 10.1186/s40425-019-0799-2
    Article link>

    Offer S, Menard J, Enríquez Pérez J, de Oliveira K, Chandran V, Johansson M, Bång-Rudenstam A,  Siesjö P, Ebbesson A, Hedenfalk I, Sundgren P, Darabi A and Belting M. Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration. (2019) Journal of Experimental & Clinical Cancer Research, doi: 10.1186/s13046-019-1228-6
    Article link >

    Ravi D, Sarkar S, Purvey S, Passero F, Beheshti A, Chen Y, Mokhtar M, David K, Konry T and Evens A. Interaction kinetics with transcriptomic and secretory responses of CD19-CAR natural killer-cell therapy in CD20 resistant non-hodgkin lymphoma. (2019) Leukemia, DOI: 10.1038/s41375-019-0663-x
    Article link>

    Sabhachandani P, Sarkar S, Mckenney S, Dashnamoorth R, Evens A and Konry T. Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release. (2019) Journal of Controlled Release, doi.org/10.1016/j.jconrel.2018.12.010
    Article link>

    Shen Q, Polomb K, Williams C, Souza de Oliveira FM, Guergova-Kuras M, Lisacek F, Karlsson N, Roviello F and Kamali-Moghaddama M. A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer. (2019) EBioMedicine, 10.1016/j.ebiom.2019.05.044
    Article link>

    Skubitz A, Boylan K, Geschwind K, Cao Q, Starr T, Geller M, Celestino J, Bast Jr R, Lu K and Koopmeiners J. Simultaneous Measurement of 92 Serum Protein Biomarkers for the Development of a Multiprotein Classifier for Ovarian Cancer Detection. (2019) Cancer Prevention Research, DOI: 10.1158/1940-6207.CAPR-18-0221
    Article link >

    Taylor M, Hughes A, Walton J, Coenen-Stass A, Magiera L, Mooney L, Bell S, Staniszewska A, Sandin L, Barry S, Watkins A, Carnealli L and Hardaker E. Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery. (2019) Journal for Immunotherapy of Cancer, DOI: 10.1186/s40425-019-0794-7
    Article link>

    Wierenga A, Cao J, Mouthaan H, van Weeghel C, Verdijk R, van Duinen S, Kroes W, Dogrusöz M, Marinkovic M, van der Burg S, Luyten G and Jager M. Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma. (2019) Investigative Ophthalmology & Visual Science, DOI: 10.1167/iovs.19-28309
    Article link>

    Zamaratskaia G, Omar NAM, Brunius C, Hallmans G, Johansson J-E, Andersson S-O, Larsson A, Åman P. and Landberg R. Consumption of whole grain/bran rye instead of refined wheat decrease concentrations of TNF-R2, e-selectin, and endostatin in an exploratory study in men with prostate cancer. (2019) Clinical Nutrition, doi.org/10.1016/j.clnu.2019.01.007
    Article link>

    2018

    Abrahamsson A, Rzepecka A and Dabrosin C. Equal Pro-inflammatory Profiles of CCLs, CXCLs, and Matrix Metalloproteinases in the Extracellular Microenvironment In Vivo in Human Dense Breast Tissue and Breast Cancer.(2018) Frontiers in Immunology, doi: 10.3389/fimmu.2017.01994
    Article link>

    Barriuso J, Custodio A, Afonso R, Alonso V, Astudillo A, Capdevila J, Carbonero R, Grande E, Jimenez-Fonseca P, Marazuela M, Rodríguez-Antona C and Aller Y. Prognostic and predictive biomarkers for somatostatin analogs, peptide receptor radionuclide therapy and serotonin pathway targets in neuroendocrine tumours. (2018) Cancer Treatment Reviews, doi.org/10.1016/j.ctrv.2018.09.00
    Article link>

    Birgirsson H, Tsimogiannis K, Freyhult E and Kamali-Moghaddam M. Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer. (2018) Translational Oncology, doi:/10.1016/j.tranon.2018.05.012
    Article link>

    Buckley A, Lynam-Lennon N, Kennedy S, Dunne M, Aird J, Foley E, Clarke N, Ravi N, O’Toole D, Reynolds J, Kennedy B and O’Sullivan J. (2018) Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma. Oncotarget, Doi: 10.18632/oncotarget.25950
    Article link>

    Caja L,Tzavlaki K, Dadras M, Tan E-J, Hatem G, Maturi N, Morén A, Wik L, Watanabe Y, Savary K, Kamali-Moghaddan M, Uhrbom L, Heldin C-H and Moustakas A. Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells. (2018) Oncogene, doi:10.1038/s41388-018-0136-0
    Article link>

    Camargo MC, Sivins A, Isajevs S, Folkmanis V, Rudzite D, Gulley M, Offerhaus J, Leja M and Rabkin C. Associations of Epstein-Barr Virus-Positive Gastric
    Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response.
    (2018) Cancers, doi:10.3390/cancers10090284
    Article link>

    Enblad G, Karlsson H, Gammelgård G, Wenthe J, Lövgren T, Amini M, Wikstrom K, Essand M, Savoldo B, Hallböök H, Höglund M, Dotti G, Brenner M, Hagberg H and Loskog A. A Phase I/IIa Trial Using CD19-Targeted ThirdGeneration CAR T Cells for Lymphoma and Leukemia. (2018) Clinical Cancer Research, doi: 10.1158/1078-0432.CCR-18-0426
    Article link>

    Enroth S, Berggrund M, Lycke M, Lundberg M, Assarsson E, Olovsson M, Stålberg K, Sundfeldt K and Gyllensten U. A two-step strategy for identification of plasma protein biomarkers for endometrial and ovarian cancer. (2018) Clinical Proteomics, doi: 10.1186/s12014-018-9216-y
    Article link>

    Franzén B, Alexeyenko A, Kamali-Moghaddam M, Hatschek T, Kanter L, Ramqvist T, Kierkegaard G, Auer G, Landegren U and Lewensohn R. Protein profiling of fine needle aspirates reveals subtype‐associated immune signatures and involvement of chemokines in breast cancer. (2018) Molecular Oncology, doi.org/10.1002/1878-0261.12410
    Article link>

    Franzén B, Kamali‐Moghaddam M,  Alexeyenko A, Hatschek T, Becker S, Wik L, Kierkegaard J, Eriksson A, Reddy Muppani N, Auer G, Landegren U and Lewensohn R. A fine needle aspiration‐based protein signature discriminates benign from malignant breast lesions. (2018) Molecular Oncology, DOI: 10.1002/1878-0261.12350
    Article link>

    Gezelius E, Flou Kristensen A, Bendahl P, Hisada Y, Risom Kristensen S, Ek L, Bergman B, Wallberg M, Falkmer U, Mackman N, Pedersen S and Belting M. Coagulation biomarkers and prediction of venous thromboembolism and survival in small cell lung cancer: A sub-study of RASTEN – A randomized trial with low molecular weight heparin. (2018) PLOS ONE, doi: 10.1371/journal.pone.0207387
    Article link>

    Gupta V and Bernardini M. Algorithms Used in Ovarian Cancer Detection: A Minireview on Current and Future Applications (2018) Journal of Applied Laboratory Medicine, DOI: 10.1373/jalm.2017.025817
    Article link>

    Palma M, Krstic A, Peña Perez L, Berglöf A, Meinke S, Wang Q, Blomberg KE, Kamali‐Moghaddam M, Shen Q, Jaremko G, Lundin J, De Paepe A, Höglund P, Kimby E, Österborg A, Månsson R and Smith E. Ibrutinib induces rapid down‐regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia‐related genes in blood and lymph nodes. (2018) British Journal of Haematology, doi.org/10.1111/bjh.15516
    Article link>

    Peng L, Cantor D, Huang C, Wang K, Baker M and Nice EC. Tissue and plasma proteomics for early stage cancer detection. (2018) Molecular Omics, 10.1039/C8MO00126J
    Article link>

    Qian J, Tikk K, Weigl K, Balavarca Y and Brenner H. Fibroblast growth factor 21 as a circulating biomarker at various stages of colorectal carcinogenesis. (2018) British Journal of Cancer, doi.org/10.1038/s41416-018-0280-x
    Article link>

    Qian J, Tikk K, Werner S, Balavarca Y, Saadat M, Hechtner M and Brenner H. Biomarker discovery study of inflammatory proteins for colorectal cancer early detection demonstrated importance of screening setting validation.(2018) Journal of Clinical Epidemiology, DOI: 10.1016/j.jclinepi.2018.07.016
    Article link>

    Ramqvist T, Näsman A, Franzén B, Bersani C, Alexeyenko A, Becker S, Haeggblom L, Kolev A, Dalianis T and Munck-Wikland E. Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome. (2018) Int. J. Mol. Sciences, doi:10.3390/ijms19040978
    Article link>

    Yeung V, Webber J, Dunlop E, Morgan H, Hutton J, Gurney M, Jones E, Falcon-Perez J, Tabi Z, Errington R and Clayton A. Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma (2018) Nanoscale, doi/10.1039/C8NR02417K
    Article link>

    2017

    Boldrup L,Troiano G,Gu X, Coates P,Fåhraeus R, Wilms T, Norberg-Spaak L, Wang L and Nylander K. Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue. (2017) Oncotarget, doi:10.18632/oncotarget.21402
    Article link>

    Boylan K, Geschwind K, Koopmeiners J, Geller M, Starr T and Skubitz A. A multiplex platform for the identification of ovarian cancer biomarkers (2017) Clinical Proteomics, DOI 10.1186/s12014-017-9169-6
    Article link>

    Bryan R, Gordon N, Abbotts B, Zeegers M, Cheng K, James N and  Ward D. Multiplex screening of 422 candidate serum biomarkers in bladder cancer patients identifies syndecan-1 and macrophage colony stimulating factor 1 as prognostic indicators. (2017) Translational Cancer Research, doi:10.21037/tcr.2017.04.19
    Article link>

    Chen H, Qian J, Werner S, Cuk K, Knebel P and Brenner H. Development and validation of a panel of five proteins as blood biomarkers for early detection of colorectal cancer. (2017) Clinical Epidemiology, doi: 10.2147/CLEP.S144171
    Article link>

    Eriksson E, Milenova I, Wenthe J, Stahle M, Leja-Jarblad J, Ullenhag G, Dimberg A, Moreno R, Alemany R and Loskog A. (2017) Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus. Clinical Cancer Research, Doi: 10.1158/1078-0432.CCR-17-0285
    Article link>

    Harlid S, Myte R and Van Guelpen B. The Metabolic Syndrome, Inflammation, and Colorectal Cancer Risk: An Evaluation of Large Panels of Plasma Protein Markers Using Repeated, Prediagnostic Samples. (2017) Mediators of Inflammation, doi:10.1155/2017/4803156
    Article link>

    Kupcova Skalnikova H, Cizkova J, Cervenka J and Vodicka P. Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research (2017) Int. J. Mol. Sci., doi:10.3390/ijms18122697
    Article link>

    Mazurkiewicz M, Hillert E-K, Wang X, Pellegrini P, Hägg Olofsson M, Selvaraju K, D’Arcy P and Linder S. Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition. (2017) Oncotarget, doi: 10.18632/oncotarget.15501
    Article link>

    Savola P, Brück O, Olson T, Kelkka T, Kauppi M, Kovanen P, Kytölä S, Sokka-Isler T, Loughran T, Leirisalo-Repo M and Mustjoki S. Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. (2017) Haematologica, doi:10.3324/haematol.2017.175729
    Article link>

    Schiza A, Wenthe J, Mangsbo S, Eriksson E, Nilsson A, Tötterman T, Loskog A and Ulenhag G. Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients. (2017) Journal of Translational Medicine, DOI: 10.1186/s12967-017-1182-z
    Article link>

    Yeh C, Adusumilli R, Kullolli M, Mallick P, John E and Pitteri S. Assessing biological and technological variability in protein levels measured in pre-diagnostic plasma samples of women with breast cancer. (2017) Biomarker Research, DOI 10.1186/s40364-017-0110-y
    Article link>

    2016

    Berggrund M, Ekman D, Gustavsson I, Sundfeldt K, Olovsson M, Enroth S and Gyllensten U. Protein Detection Using the Multiplexed Proximity Extension Assay (PEA) from Plasma and Vaginal Fluid Applied to the Indicating FTA Elute Micro Card. J. Circ. Biomark. (2016), 5:9. doi:10.5772/64000
    Article link >

    Chen H, Knebel P and Brenner H. Empirical evaluation demonstrated importance of validating biomarkers for early detection of cancer in screening settings to limit the number of false-positive findings. (2016) Journal Clinical Epidemiology, doi.org/10.1016/j.jclinepi.2016.01.022
    Article link>

    Darmanis S, Gallant C, Marinescu V,  Niklasson M, Segerman A,  Flamourakis G,  Fredriksson S, Assarsson E, Lundberg M, Nelander S, Westermark B and  Landegren U. Simultaneous Multiplexed Measurement of RNA and Proteins in Single Cells. (2016) Cell Reports 14, 380-389.
    Article link >

    Edfeldt K, Daskalakis K, Bäcklin C, Norlén O, Tiensuu Janson E, Westin G, Hellman P and Stålberg P. DcR3, TFF3 and Midkine are Novel Serum Biomarkers in Small Intestinal Neuroendocrine Tumors. (2016) Neuroendocrinology, DOI: 10.1159/000452891
    PubMed link>

    Genshaft A, Li S, Gallant C, Darmanis S, Prakadan S, Ziegler C, Lundberg M, Fredriksson S, Hong J, Regev A, Livak K, Landegren U and Shalek A. Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction. (2016) Genome Biology, 17:188 DOI 10.1186/s13059-016-1045-6
    Article link>

    Loskog A, Maleka A, Mangsbo S, Svensson E, Lundberg C, Nilsson A, Krause J, Agnarsdottir M, Sundin A, Ahlström H, Tötterman T and Ullenhag G. Immunostimulatory AdCD40L gene therapy combined with low-dose cyclophosphamide in metastatic melanoma patients. British Journal of Cancer (2016) 114, 872–880. doi:10.1038/bjc.2016.42
    Article link >

    Mailankody S, Devlin S, Korde N, Lendvai N, Lesokhin A, Landau H, Hassoun H, Ballagi A, Ekman D, Chung D, Patel M, Koehne G, Giralt S and Landgren O. Protein profiling in plasma cell disorders: a feasibility study. (2016) Leukemia & Lymphoma, DOI: 10.1080/10428194.2016.1258699
    PubMed link>

    Schneiderova P, Pika T, Gajdos P, Fillerova R, Kromer P, Kudelka M, Minarik J, Papajik T, Scudla V and Kriegova E. Serum protein fingerprinting by PEA immunoassay coupled with a pattern-recognition algorithms distinguishes MGUS and multiple myeloma. (2016) Oncotarget.
    Article link >

    Söderlund S, Christiansson L, Persson I, Hjorth-Hansen H, Richter J, Simonsson B, Mustjoki S, Olsson-Strömberg U and Loskog A. Plasma proteomics in CML patients before and after initiation of tyrosine kinase inhibitor therapy reveals induced Th1 immunity and loss of angiogenic stimuli. (2016) Leukemia Research, DOI: 10.1016/j.leukres.2016.09.019
    Article link>

    2015

    Chen H, Zucknick M, Werner S, Knebel P, Brenner H. Head-to-Head Comparison and Evaluation of 92 Plasma Protein Biomarkers for Early Detection of Colorectal Cancer in a True Screening Setting. Clin Cancer Res. (2015) Jul 15;21(14):3318-26. doi: 10.1158/1078-0432.CCR-14-3051. Epub 2015 May 26.
    PubMed link >

    Christiansson L, Söderlund S, Mangsbo S, Hjort-Hansen H, Höglund M, Markevärn B, Richter J, Stenke L, Mustjoki S, Loskog A, Olsson-Strömberg U. The tyrosine kinase inhibitors imatinib and dasatinib reduce myeloid suppressor cells and release effector lymphocyte responses. Mol Cancer Ther. (2015) May;14(5):1181-91. doi: 10.1158/1535-7163.MCT-14-0849.
    PubMed link >

    Mahboob S, Ahn SB, Cheruku HR, Cantor D, Rennel E, Fredriksson S, Edfeldt G, Breen EJ, Khan A, Mohamedali A, Muktadir MG, Ranganathan S, Tan S-H, Nice E, Baker MS. A novel multiplexed immunoassay identifies CEA, IL-8 and prolactin as prospectivemarkers for Dukes’ stages A-D colorectal cancers. Clinical Proteomics (2015) Apr 8;12(1):10. doi:10.1186/s12014-015-9081-x. eCollection 2015.
    PubMed link >

    Enroth S, Johansson Å, Bosdotter Enroth S and Ulf Gyllensten U. Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs. Nature Commun. (2014) Aug 22;5:4684. doi: 10.1038/ncomms5684.
    PubMed link >


    Opthalmology

    2020

    Lois N, Gardner E, McFarland M, et. al. A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema. (2020) Journal of Clinical Medicine, DOI: /10.3390/jcm9072225
    Article link>

    2018

    Csösz E, Tóth N, Deák, E, Csutak A and Tözsér J. Wound-Healing Markers Revealed by Proximity Extension Assay in Tears of Patients following Glaucoma Surgery. (2018) Int. J. Mol. Sci, doi:10.3390/ijms19124096
    Article link>


    Other diseases & syndromes

    2020

    Bue M, Leth Bergholt N, Kruse Jensen L, et. al. Inflammatory proteins in infected bone tissue – An explorative porcine study. (2020) Bone Reports, DOI: 10.1016/j.bonr.2020.100292
    Article link>

    Horati H, Janssens H, Margaroli C, Veltmana M, Stolarczyk M, Kilgoreb M, Chou G, Peng L, Tiddens H, Chandler J, Tirouvanziam R and Scholte B. Airway profile of bioactive lipids predicts early progression of lung disease in cystic fibrosis. (2020) Journal of Cystic Fibrosis, DOI: 10.1016/j.jcf.2020.01.010
    Article link>

    Previtiali S, Gidaro T, Diaz-Manera J, et. al. Rimeporide as a first- in-class NHE-1 inhibitor: Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy. (2020) Pharmacological Research, DOI: 10.1016/j.phrs.2020.104999
    Article link>

    Weivoda M, Chew CK, Monroe D, Farr J, Atkinson E, Geske J, Eckhardt B, Thicke B, Ruan M, Tweed A, McCready L, Rizza R, Matveyenko A, Kassem M, Levin Andersen T, Vella A, Drake M, Clarke B, Oursler MJ and Khosla S. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. (2020) Nature Communications, DOI: 10.1038/s41467-019-14003-6
    Article link>

    2019

    Zheng J, Maerz W, Gergei I et. al. Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures. (2019) Journal of Bone and Mineral Research, DOI: 10.1002/jbmr.3803
    Article link>

    2018

    Panezai J, Ghaffar A, Altamash M, Engström P-E and Larsson A. Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. (2018) PLOS ONE, doi.org/10.1371/journal.pone.0197235
    Article link>

    2017

    Roerink M, Knoop H, Bronkhorst E, Mouthaan H, Luuk Hawinkels J, Joosten L and van der Meer J. Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment. (2017) Journal of Translational Medicine, doi: 10.1186/s12967-017-1371-9
    Article link>

    2015

    Pauk M, Grgurevic L, Brkljacic J, Kufner V Bordukalo-Niksic T, Grabusic K, Razdorov G, Rogic D, Zuvic M, Oppermann H, Babitt J, Lin H, Volarevic S and Vukicevic S. Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice (2015) International Orthopaedics, doi: 10.1007/s00264-014-2550-4
    PubMed link>


    Respiratory disease

    2020

    Jónsdóttir B, Ziebell Severinsen M, von Wowern F, San Miguel C, Goetze J and Melander O. ST2 Predicts Mortality In Patients With Acute Hypercapnic Respiratory Failure Treated With Noninvasive Positive Pressure Ventilation. (2020) International Journal of Chronic Obstructional Pulmonary Disease, DOI: 10.2147/COPD.S211448
    Article link>

    2019

    Kraen M, Frantz S, Nihlén U, Engström G, Löfdahl C, Wollmer P and Dencker M. Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking (2019) PLOS One, doi.org/10.1371/journal.pone.0211987
    Article link>

    Salomonsson M, Malinovschi A, Kalm‐Stephens P, Dahlin J, Janson C, Alving K and Hallgren J. Circulating mast cell progenitors correlate with reduced lung function in allergic asthma. (2019) Clinical & Experimental Allergy, doi: 10.1111/cea.13388
    Article link>

    Tebroke J, Lieverse J, Säfholm J, Schulte G, Nilsson G and Rönnberg E. Wnt-3a Induces Cytokine Release in Human Mast Cells. (2019) Cells, DOI: 10.3390/cells8111372
    Article link>

    Tsolakis N, Nordvall L, Janson C, Rydell N, Malinovschi A and Alving K. Characterization of a subgroup of non-type 2 asthma with cow’s milk hypersensitivity in young subjects. (2019) Clinical and Translational Allergy, doi.org/10.1186/s13601-019-0250-2
    Article link>

    2018

    Kasaian M, Lee J, Brennan A, Danto S, Black K, Fitz L and Dixon A. Proteomic analysis of serum and sputum analytes distinguishes controlled and poorly-controlled asthmatics. (2018) Journal of the British Society for Allergy and Clinical Immunology, doi.org/10.1111/cea.13151
    Article link>

    2017

    Bhargava M, Viken K, Wang Q, Jagtap P, Bitterman P, Ingbar D and Wendt C. Bronchoalveolar Lavage Fluid Protein Expression in Acute Respiratory Distress Syndrome. (2017) Scientific Reports, DOI:10.1038/s41598-017-07791-8
    Article link>

    Jónsdóttir B, Jaworowski Å, San Miguel C and Melander O. IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation (2017) BMC Pulmonary Medicine, DOI: 10.1186/s12890-017-0377-7
    Article link >


    Technical studies

    2020

    Raffield L, Dang H, Pratte K, et. al. Comparison of Proteomic Assessment Methods in Multiple Cohort Studies. (2020) Proteomics, DOI: 10.1002/pmic.201900278
    Article link>

    2018

    Frändberg S, Asp J, Waldner B, Holgersson J and Palmqvist L. Concentration of the CDCP1 protein in human cord plasma may serve as a predictor of hematopoietic stem and progenitor cell content. (2018) Stem Cell Research, doi.org/10.1016/j.scr.2018.03.008
    Article link>

    Siarta B, Marques Souza de Oliveirac F, Shenc Q, Björkestenc J, Pekard T, Steinborne R, Nimmerichterf A, Kamali-Moghaddamc M and Wallnerb B. Protein measurements in venous plasma, earlobe capillary plasma and in plasma stored on filter paper. (2018) Analytical Biochemistry, doi.org/10.1016/j.ab.2018.11.016
    Article link>

    2017

    Björkesten J, Enroth S, Shen Q, Wik L, Hougaard D, Cohen A, Sörensen L, Giedraitis V, ingelsson M, Larsson A, Kamali-Moghaddam M and Landegren U. Stability of Proteins in Dried Blood Spot Biobanks (2017) Molecular & Cellular Proteomics, doi: 10.1074/mcp.RA117.000015
    Article link>

    Larssen P, Wik L, Czarnewski P, Eldh M, Lof L, Ronquist J, Dubois L, Freyhult E, Gallant C, Oelrich J, Larsson A, Ronquist G, Villablanca E, Landegren U, Gabrielsson S and Kamali-Moghaddam M. Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assay (2017) Molecular & Cellular Proteomics, doi: 10.1074/mcp.M116.064725
    Article link>

    Shen Q, Björkesten J, Galli J, Ekman D, Broberg J, Nordberg N, Tillander A, Kamali-Moghaddam M, Tybring G and Landegren U. Strong impact on plasma protein profiles by precentrifugation delay but not by repeated freeze-thaw cycles, as analyzed using multiplex proximity extension assays. (2017) Clinical Chemistry and Laboratory Medicine, doi: 10.1515/cclm-2017-0648
    Article link>

    2016

    Enroth S, Hallmans G, Grankvist K and Gyllensten, U. Effects of long-term storage time and original sampling month on biobank plasma protein concentrations. EBioMedicine (2016), 201608.038
    Article link >

    Yang X, Tang Y, Alt, R, Xie, X and Lia, F. Emerging techniques for ultrasensitive protein analysis. Analyst (2016), 10.1039/C6AN00059B. (Review article).
    Article link >

    2015

    Greenwood C, Ruf D, Kirvell S, Johnson G, Dhillon HS, Bustin SA. Proximity assays for sensitive quantification of proteins. Biomol Det and Quantif. (2015). 4:10-16.
    Article link >

    2014

    Assarsson E, Lundberg M, Holmquist G, Björkesten J, Thorsen SB, Ekman D, Eriksson A, Rennel Dickens E, Ohlsson S, Edfeldt G, Andersson A-C, Lindstedt P, Stenvang J, Gullberg M, and Fredriksson S. Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability. PLOS one. April 24, (2014).
    Article link >

    Solier C, Langen H. Antibody-based proteomics and biomarker research – current status and limitations. Proteomics. (2014) Mar;14(6):774-83. doi: 10.1002/pmic.201300334.
    PubMed link >


    Urology

    2019

    Dizeyi N, Yao Mattisson I, Ramnemark L, Grabe M and Abrahamsson P-A. (2019) The effects of Cernitin® on inflammatory parameters and benign prostatic hyperplasia: An in vitro study. Phytotherapy Research, doi: 10.1002/ptr.6438
    Article link>


    Wider proteomics studies

    2020

    Hillary R, Trejo-Banos D, Kousathanas A, et. al. Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. (2020) Genome Medicine, DOI: 10.1186/s13073-020-00754-1
    Article link>

    Nice, E. The status of proteomics as we enter the 2020s: Towards personalised/precision medicine. (2020) Analytical Biochemstry, DOI: 10.1016/j.ab.2020.113840
    Article link>

    Zhong W, Gummesson A, Tebani A, et al.  Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort. (2020) Genome Medicine, DOI: 10.1186/s13073-020-00755-0
    Article link>

    2019

    Benson M, Ngo D, Ganz P and Gerszten R. Emerging Affinity Reagents for High Throughput Proteomics. (2019) Circulation, DOI: 10.1161/CIRCULATIONAHA.119.039912
    Article link>

    Bergholt N, Olesen M and Foldager C. Age-Dependent Systemic Effects of a Systemic Intermittent Hypoxic Therapy In Vivo. (2019) High Altitude Medicine & Biology, doi.org/10.1089/ham.2018.0113
    Article link >

    Kellie J, Sikorski T, An B, Chen Z, Moghieb A, Busz M, Szapacs M and Angel T. A new era for proteomics. (2019) Bioanalysis, DOI: 10.4155/bio-2019-0191
    Article link>

    Lind L, Sundström J, Larsson A, Lampa E, Ärnlöv J and Ingelsson E. Longitudinal effects of aging on plasma proteins levels in older adults – associations with kidney function and hemoglobin levels. (2019) PLOS One.doi.org/10.1371/journal.pone.0212060
    Article link>

    Rajan M, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton N, Biörserud C, Lindahl T, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman J, Perkins R, Wallenius V, Lange S and Börgeson E. Comparative analysis of obesity related cardiometabolic and renal biomarkers in human plasma and serum. (2019) Scientific Reports, DOI: 10.1038/s41598-019-51673-0
    Article link>

    Uhlén M et al. The human secretome. (2019) Science Signaling, DOI: 10.1126/scisignal.aaz0274
    Article link>

    2018

    Landegren U, Al-Amin R and Björkesten J. A myopic perspective on the future of protein diagnostics. (2018) New Biotechnology, doi.org/10.1016/j.nbt.2018.01.002
    Article link>

    Sun B, Maranville J, Peters J, Stacey D, Staley J, Blackshaw J, Burgess S, Jiang T, Paige E, Surendran P, Oliver-Williams C, Kamat M, Prins B, Wilcox S, Zimmerman E, Chi A, Bansal N, Spain S, Wood A, Morrel N, Bradley J, Janjic N, Roberts D, Ouwehand W. Todd J, Soranzo N. Suhre K, Dirk D,  Fox C, Plenge R, Danesh J, Runz H and Butterworth A. Genomic atlas of the human plasma proteome (2018) Nature,  doi: 10.1038/s41586-018-0175-2
    Article link>

    Sundkvist A, Myte R, Bodén, S, Enroth S, Gyllensten U, Harlid S and van Guelpen B. Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff. (2018) Scientific Reports, DOI:10.1038/s41598-018-20794-3
    Article link>

    2017

    Ahsan M, Ek W, Rask-Andersen M, Karlsson T, Lind-Thomsen A, Enroth S, Gyllensten U and Johansson Å. The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases. (2017) PLOS Genetics, DOI: 10.1371/journal.pgen.1007005
    Article link>

    Brodin P & Davis M. Human immune system variation (2017), Nat. Rev. Immunol, 17, 21-29
    Article link >

    Price N, Magis A, Earls J, Glusman G, Levy R, Lausted C, McDonald D, Kusebauch U, Moss C, Zhou Y, Qin S, Moritz R, Brogaard K, Omenn G, Lovejoy J and Hood L. A wellness study of 108 individuals using personal, dense, dynamic data clouds. Nature Biotechnology (2017), doi:10.1038/nbt.3870
    Article link>

    Schwenk J, Omenn G, Sun Z, Campbell D, Baker M, Overall C, Aebersold R, Moritz R and Deutsch E. The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays (2017) Journal of Proteome Research, doi:10.1021/acs.jproteome.7b00467
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    Villani A-C, Satija1 R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, Griesbeck M, Butler A, Zheng S, Lazo S, Jardine L, Dixon D, Stephenson E, Nilsson E, Grundberg I, McDonald D, Filby A, Li W, De Jager P, Rozenblatt-Rosen O, Lane A, Haniffa M, Regev A and Hacohen N. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. (2017) Science, DOI: 10.1126/science.aah4573
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    2015

    Enroth S, Bosdotter Enroth S, Johansson Å, Gyllensten U. Effect of genetic and environmental factors on protein biomarkers for common noncommunicable disease and use of personally normalized plasma protein profiles (PNPPP). Biomarkers. (2015) Sep;20(6-7):355-64. doi: 10.3109/1354750X.2015.1093546.
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    Enroth S, Enroth SB, Johansson Å, Gyllensten U. Protein profiling reveals consequences of lifestyle choices on predicted biological aging. Sci Rep. (2015) Dec 1;5:17282. doi: 10.1038/srep17282
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    Larsson A, Carlsson L, Gordh T, Lind A-L, Thulin M, Kamali-Moghaddam M. The effects of age and gender on plasma levels of 63 cytokines. Clin Cancer Res. (2015) Jul 15;21(14):3318-26. doi: 10.1158/1078-0432.CCR-14-3051.
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    Larsson A, Carlsson L, Lind A-L, Gordh T, Bodolea C, Kamali-Moghaddam M, Thulin M. The body mass index (BMI) is significantly correlated with levels of cytokines and chemokines in cerebrospinal fluid. Cytokine. (2015) Jul 15. pii: S1043-4666(15)30020-X. doi: 10.1016/j.cyto.2015.07.010.
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