Some of the proteins addressed by our panels have a very broad range of expression levels in vivo, which makes it difficult to develop an assay in multiplex that can measure both healthy and diseased individuals.
For example, some of the assays on the CVD-panels are developed mainly to measure the elevated levels that can be seen after or during cardiovascular disease. If you would still like to use the results from an assay with low detectability you can use non-parametric statistics (i.e. detected vs. not detected in your groups).