Exploring molecular phenotypes of incident breast cancer through population-based proteogenomics

Proteins play key roles in malignant transformation and represent an important hub for oncogenic signaling. Elevated levels of circulating proteins could potentially be identified years before the onset of cancer and its detection by current diagnostics. This webinar focuses on exploring the power of proteomic discoveries, at the population scale in a breast cancer cohort, and the integration of proteogenomics to generate key biological insights into risk prediction that may lead to translational applications for breast cancer prevention.

Speaker: Dr. Anders Mälarstig (Director of Target Sciences, Pfizer Worldwide Research and Development)

webinar November 23 2021

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The webinar covers the following points:

  • The importance of integrating multi-omics at a systemic level to generate key biological insights for cancer prevention, diagnosis, and treatment
  • Emerging large-scale cancer proteomics analyses at the population level
  • Using high-throughput proteomics to find actionable biomarkers to better understand and treat human cancer.

Original Broadcast date:  November 23 2021

Dr. Mälarstig received his Ph.D. in cardiovascular genetics from Uppsala University in 2006 and then did postdoctoral training at the Karolinska Institute in Stockholm. In 2009 he joined Pfizer, where he is now director of Target Sciences. In his current role, he is responsible for developing and applying strategies for new drug targets and precision medicine. He has extensive experience working in international academic consortia and public-private partnerships such as the SCALLOP consortium, which recently published their first article in Nature Metabolism, entitled “Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.”

2947

Biomarker assays

~881 million

Protein data points generated

907

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