Oncology_II

Gene
KIR2DL2

Uniprot
P43627

Protein
Killer cell immunoglobulin-like receptor 2DL2

See alternative names
Natural killer-associated transcript 6,
p58 natural killer cell receptor clone CL-43,
MHC class I NK cell receptor,
CD158 antigen-like family member B1

Uniprot Function Description

Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.

Additional notes

KIR2DL2 shares ~88% amino acid sequence identity with KIR2DS4 (P43632) and some degree of cross-reactivity can be expected. Further testing to establish the signal contribution at different NPX levels is ongoing and will be published here during 2022 when available.

Sample type

Human EDTA plasma and serum are the recommended sample types. Human citrate plasma and heparin plasma are also accepted. For other samples types e.g cerebrospinal fluid, (CSF), tissue or cell lysates please we recommend Olink Target 96 panels. Please note that protein expression levels are expected to vary in different sample types and certain assays may be affected by interfering substances such as hemolysate.

Precision

Precision (repeatability) is calculated from linearized NPX values over LOD.

Within run precision Coefficient of Variation (CV)
15%
Between run precision Coefficient of Variation (CV)
27%

Analytical measuring range

The technical data reported below refers to the measured value in the in vitro validation assays run using known concentrations of recombinant antigen. Please note that these figures are for reference only and CANNOT be used to convert NPX values to absolute concentrations for proteins measured in plasma or serum samples.

LOD (pg/ml)
97.7
LLOQ (pg/ml)
97.7
ULOQ (pg/ml)
6250
Hook (pg/ml)
50000
Range (logs)
1.8

Dilution factor

For optimal assay readout, Olink Explore is run using different dilutions of the original samples (undiluted, 1:10, 1:100 or 1:1000). The dilution factor for this assay is noted below and should be taken into account when estimating the appropriate addressable biological concentration of the protein based on the in vitro validation data.

Dilution factor
1:1

Sensitivity plot

The calibrator curve shown below visualizes the analytical measuring range data based on in vitro measurement of recombinant antigen. Please note that this is shown for reference only and CANNOT be used to convert NPX values to absolute concentrations for proteins measured in plasma or serum samples. The vertical dotted lines represent LLOQ and ULOQ respectively, and the horizontal line indicates the LOD.

Sample distribution plot

The plot below shows the levels of protein measured in a number of commercial plasma samples. Healthy subjects are shown in blue and samples obtained from patients with a range of diseases are shown in red. The latter include inflammatory, cardiovascular, autoimmune & neurological diseases, as well as cancer. The data is shown to give a general idea of the sort of NPX range to expect, but cannot cover all potential levels that may be seen in clinical samples.

2947

Biomarker assays

~881 million

Protein data points generated

940

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