Gastric intrinsic factor (GIF)

Links to databases

 

Gastric intrinsic factor is a secreted glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 in the small intestine. Defficiencies in gastric intrinsic factor lead to malabsorption of vitamin B12 and subsequent megaloblastic anemia.

Sample type

Analytical Measuring Range

Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (https://www.olink.com/question/what-is-npx).

LOD (pg/mL)
0.48
LLOQ (pg/mL)
0.48
ULOQ (pg/mL)
31250
Hook (pg/mL)
125000
Range (logs)
4.8

Calibrator curve for validation data (generated in multiplex)

Gastric intrinsic factor (GIF)

Precision

Within run precision Coefficient of Variation (CV)
11%
Between run precision Coefficient of Variation (CV)
15%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents – go to Document download center

2947

Biomarker assays

~851 million

Protein data points generated

768

Publications listed on website

35

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