Myeloperoxidase (MPO)

Links to databases

Description

Myeloperoxidase is a leukocyte-derived enzyme that catalyzes the formation of reactive oxidants and may promote plaque formation and rupture.

Sample type

Recommended sample types are EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact support@olink.com for more information.

Analytical Measuring Range

Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (https://www.olink.com/question/what-is-npx).

Since the CVD III panel uses human samples diluted 100-fold, a multiplication factor of 100 should be applied when comparing the addressable biological concentration to this validation data.

LOD (pg/mL)
7.63
LLOQ (pg/mL)
7.63
ULOQ (pg/mL)
7812
Hook (pg/mL)
15625
Range (logs)
3

Calibrator curve for validation data (generated in multiplex)

Myeloperoxidase (MPO)

Precision

Within run precision Coefficient of Variation (CV)
7%
Between run precision Coefficient of Variation (CV)
8%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents – go to Document download center

2947

Biomarker assays

~851 million

Protein data points generated

780

Publications listed on website

35

Certified Core Labs

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