Galectin-1 (Gal-1) belongs to a family of proteins defined by their binding specificity for ?-galactoside sugars, but which unlike most membrane-bound lectins, are soluble proteins with both intra- and extracellular functions. Gal-1 contains a single carbohydrate recognition domain through which it can bind glycans both as a monomer and as a homodimer. This protein has multiple proposed functions, including apoptosis, cell proliferation and cell differentiation. More specifically, Gal-1 is a potent inducer of T-cell apoptosis and its expression in Hodgkin Lymphoma has been shown to mediate immunosuppression of CD8+ T-cells.
Recommended sample types are EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact email@example.com for more information.
Analytical Measuring Range
Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (https://www.olink.com/question/what-is-npx).
Calibrator curve generated in multiplex
Within run precision Coefficient of Variation (CV)
Between run precision Coefficient of Variation (CV)
Precision (repeatability) is calculated from linearized NPX values over LOD.
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents – go to Document download center