• CD2-associated protein (CD2AP)

    Links to databases

    Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.

    Sample type

    Recommended sample types are EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact support@olink.com for more information.

    Analytical Measuring Range

    Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (https://www.olink.com/question/what-is-npx).

    Since the Metabolism panel uses human samples diluted 10-fold, a multiplication factor of 10 should be applied when comparing the addressable biological concentration to this validation data.

    LOD (pg/mL)
    244
    LLOQ (pg/mL)
    244
    ULOQ (pg/mL)
    31250
    Hook (pg/mL)
    125000
    Range (logs)
    2.1

    Calibrator curve for validation data (generated in multiplex)

    CD2-associated protein (CD2AP)

    Precision

    Within run precision Coefficient of Variation (CV)
    7%
    Between run precision Coefficient of Variation (CV)
    8%

    Precision (repeatability) is calculated from linearized NPX values over LOD.

    Biomarker Validation Data

    Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents – go to Document download center

    2947

    Biomarker assays

    ~881 million

    Protein data points generated

    886

    Publications listed on website

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