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Olink Target 96 Cell Regulation
Casting a broader net to further explore the complexity of the human proteome
Complementing and expanding on our previous portfolio of disease area-focused biomarker panels, our exploratory panels offers scientists the chance to cast a wider net in the quest to identify new biomarkers and relevant protein signatures, offering many new assays focused on important biological processes with wide-ranging clinical relevance.
The Cell Regulation panel offers simultaneous analysis of 92 protein biomarkers using just 1 µL of biological sample, and all assays are subject to Olink’s strict technical validation and QC control procedures. The selection of protein biomarker assays is designed to provide the optimal dynamic range, as well as to focus on proteins with relevance for cell regulation processes. Categorization of the proteins included in the panel was carried out via referral to widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET. The assays in this panel include proteins involved in key biological processes such as cell communication, apoptotic process, cell cycle and cell differentiation.
To see some recent peer-reviewed publications in which novel protein profiles were described that included some biomarkers identified using the Cell Regulation panel – see the publications highlight page.
An alphabetical list of the 92 proteins with links to the individual biomarker pages containing additional information and assay validation data can be found at the bottom of this page.
An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class (based on widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET) can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data. Please note that these classifications are intended for general guidance only and while correct at the time of publication, they are not updated in real-time and you are advised to always check the source databases in order to see the latest updates regarding the information for specific proteins.
Biological Process
Disease Area
Tissue Expression
Protein Class
A comprehensive list of all protein biomarkers that can be measured using the currently available biomarker panels can be seen on the biomarker library page.
Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>
If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.
The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.
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Amphoterin-induced protein 2 (AMIGO2)
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Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP)
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Anterior gradient protein 3 (AGR3)
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Arylsulfatase B (ARSB)
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ATP-dependent 6-phosphofructokinase, muscle type (PFKM)
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Bcl-2-like protein 11 isoform BimL (BCL2L11)
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Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)
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Biglycan (BGN)
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Bile salt sulfotransferase (SULT2A1)
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Breakpoint cluster region protein (BCR)
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Brother of CDO (BOC)
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C-type mannose receptor 2 (MRC2)
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Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1)
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Calsyntenin-3 (CLSTN3)
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Cell growth-regulating nucleolar protein (LYAR)
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Cellular tumor antigen p53 (TP53)
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Cerebral dopamine neurotrophic factor (CDNF)
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Collagen alpha-1(IV) chain (COL4A1)
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Cone-rod homeobox protein (CRX)
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Cryptic protein (CFC1)
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Cysteine protease ATG4A (ATG4A)
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Cysteine-rich secretory protein 2 (CRISP2)
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Dickkopf-like protein 1 (DKKL1)
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Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)
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DnaJ homolog subfamily B member 1 (DNAJB1)
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Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)
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Dynactin subunit 2 (DCTN2)
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E3 ubiquitin-protein ligase CBL (CBL)
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Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6)
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Fibroblast growth factor 21 (FGF21)
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Friend leukemia integration 1 transcription factor (FLI1)
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Galectin-7 (LGALS7)
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Gamma-secretase-activating protein (GSAP)
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Gastrokine (GKN1)
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GDNF family receptor alpha-2 (GFRA2)
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Glucagon (GCG)
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Growth hormone variant (GH2)
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Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1)
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Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1)
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Immunoglobulin superfamily member 3 (IGSF3)
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Interleukin-17 receptor B (IL17RB)
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Kallikrein-12 (KLK12)
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Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1)
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Leucine-rich repeat neuronal protein 1 (LRRN1)
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Ly6/PLAUR domain-containing protein 1 (LYPD1)
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Lymphoid-restricted membrane protein (LRMP)
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Methionine aminopeptidase 1D, mitochondrial (METAP1D)
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Myelin-oligodendrocyte glycoprotein (MOG)
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N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)
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NF-kappa-B inhibitor epsilon (NFKBIE)
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Nicalin (NCLN)
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Ninjurin-1 (NINJ1)
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Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)
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Oligodendrocyte-myelin glycoprotein (OMG)
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Opticin (OPTC)
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Peroxiredoxin-6 (PRDX6)
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Podocalyxin-like protein 2 (PODXL2)
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Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2)
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Probable carboxypeptidase X1 (CPXM1)
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Prokineticin-1 (PROK1)
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Prolactin regulatory element-binding protein (PREB)
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Protein FAM19A5 (FAM19A5)
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Protein Wnt-9a (WNT9A)
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Protocadherin-17 (PCDH17)
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Ras GTPase-activating-like protein IQGAP2 (IQGAP2)
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Regulator of G-protein signaling 8 (RGS8)
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Rho GTPase-activating protein 1 (ARHGAP1)
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Rho guanine nucleotide exchange factor 12 (ARHGEF12)
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Seizure 6-like protein 2 (SEZ6L2)
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Semaphorin-4C (SEMA4C)
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Serine/threonine-protein kinase PAK 4 (PAK4)
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Sialic acid-binding Ig-like lectin 10 (SIGLEC10)
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Sialic acid-binding Ig-like lectin 6 (SIGLEC6)
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SLAM family member 8 (SLAMF8)
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SLIT and NTRK-like protein 2 (SLITRK2)
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SLIT and NTRK-like protein 6 (SLITRK6)
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Src kinase-associated phosphoprotein 1 (SKAP1)
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Syntaxin-16 (STX16)
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Syntaxin-6 (STX6)
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T-cell leukemia/lymphoma protein 1B (TCL1B)
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Transcription factor AP-1 (JUN)
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Transforming acidic coiled-coil-containing protein 3 (TACC3)
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Tudor and KH domain-containing protein (TDRKH)
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Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
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Tumor-associated calcium signal transducer 2 (TACSTD2)
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Vascular endothelial growth factor D (VEGFD)
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Vesicle-associated membrane protein 5 (VAMP5)
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VPS10 domain-containing receptor SorCS2 (SORCS2)
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Wiskott-Aldrich syndrome protein family member 1 (WASF1)
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Wiskott-Aldrich syndrome protein family member 3 (WASF3)
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Zinc finger and BTB domain-containing protein 16 (ZBTB16)
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Zinc finger and BTB domain-containing protein 17 (ZBTB17)