A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS13)

Links to databases

 

ADAM-TS 13 (also known as von Willebrand factor-cleaving protease, VWFCP) is a is a zinc-containing metalloprotease that cleaves vWF multimers in plasma and so controls vWF-mediated platelet thrombus formation. Defficiency in ADAM-TS13 gives rise to thrombotic thrombocytopenic purpura, in which small blood vessels throughout the body are subject to extensive microscopic clots that can lead to signficant organ damage.

Sample type

Analytical Measuring Range

    • LOD (pg/mL)
    • 122.07
    • LLOQ (pg/mL)
    • 244.14
    • ULOQ (pg/mL)
    • 125000
    • Hook (pg/mL)
    • 500000
    • Range (logs)
    • 2.7

Calibrator curve for validation data (generated in multiplex)

A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS13)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 4%
    • Between run precision Coefficient of Variation (CV)
    • 10%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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