Lactoylglutathione lyase (GLO1)

Links to databases

 

GLO1 (also known as glyoxalase I) is an enzyme that catalyzes the conversion of hemimercaptal to S-lactoylglutathione. This is the first step in the critical glyoxalase system that detoxifies methylglyoxal, a byproduct of normal biochemistry that is highly toxic due to its reactivity with proteins, nucleic acids, and other cellular components. GLO1 is also involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Inhibition studies indicate that GLO1-mediated reduction of methylglyoxal is required for normal osteoclastogenesis.

Sample type

Analytical Measuring Range

    • LOD (pg/mL)
    • 0.95
    • LLOQ (pg/mL)
    • 0.95
    • ULOQ (pg/mL)
    • 31250
    • Hook (pg/mL)
    • 125000
    • Range (logs)
    • 4.5

Calibrator curve for validation data (generated in multiplex)

Lactoylglutathione lyase (GLO1)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 8%
    • Between run precision Coefficient of Variation (CV)
    • 11%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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