Tyrosine-protein kinase Mer (MERTK)

Links to databases

 

MERTK is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Mutation in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Sample type

Analytical Measuring Range

    • LOD (pg/mL)
    • 244.14
    • LLOQ (pg/mL)
    • 244.14
    • ULOQ (pg/mL)
    • 1000000
    • Hook (pg/mL)
    • 1000000
    • Range (logs)
    • 3.6

Calibrator curve for validation data (generated in multiplex)

Tyrosine-protein kinase Mer (MERTK)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 10%
    • Between run precision Coefficient of Variation (CV)
    • 10%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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