Lipoprotein lipase (LPL)

Links to databases


LPL lipase functions in the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). It is secreted from parenchymal cells as a glycosylated homodimer, and is found attached to the luminal surface of endothelial cells in capillaries by heparin sulfated proteoglycans. It is most widely distributed in adipose, heart, and skeletal muscle tissue. Mutations in the LPL gene lead to Lipoprotein lipase deficiency, resulting in elevated levels of triglycerides in the bloodstream.

Sample type

Analytical Measuring Range

    • LOD (pg/mL)
    • 0.48
    • LLOQ (pg/mL)
    • 0.95
    • ULOQ (pg/mL)
    • 125000
    • Hook (pg/mL)
    • 1000000
    • Range (logs)
    • 5.1

Calibrator curve for validation data (generated in multiplex)

Lipoprotein lipase (LPL)


    • Within run precision Coefficient of Variation (CV)
    • 7%
    • Between run precision Coefficient of Variation (CV)
    • 8%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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