Proheparin-binding EGF-like growth factor (HB-EGF)

Links to databases


Proheparin-binding EGF-like growth factor is cleaved into heparin-binding EGF-like growth factor. HBEGF is an epidermal growth factor produced by monocytes and macrophages that mediaates its effect via EGFR, ERBB2 and ERBB4. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function.

Sample type

Analytical Measuring Range

    • LOD (pg/mL)
    • 0.48
    • LLOQ (pg/mL)
    • 0.48
    • ULOQ (pg/mL)
    • 7812
    • Hook (pg/mL)
    • 31250
    • Range (logs)
    • 4.2

Calibrator curve for validation data (generated in multiplex)

Proheparin-binding EGF-like growth factor  (HB-EGF)


    • Within run precision Coefficient of Variation (CV)
    • 8%
    • Between run precision Coefficient of Variation (CV)
    • 10%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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