Leptin (LEP)

Links to databases

 

Leptin is a adipose cell-derived hormone that regulates energy balance by inhibiting hunger. In obesity, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high energy stores. Leptin levels vary exponentially with fat mass and also exhibit a daily cyclic pattern, with higher levels in blood between midnight and early morning, perhaps suppressing appetite during the night. This diurnal rhythm of blood leptin levels may be modified by meal-timing. Leptin levels are also known to be affected my multiple physical stimuli, such as emotional stress, sleep deprivation and physical exercise.

Sample type

Analytical Measuring Range

    • LOD (pg/mL)
    • 244.14
    • LLOQ (pg/mL)
    • 976.56
    • ULOQ (pg/mL)
    • 500000
    • Hook (pg/mL)
    • 8000000
    • Range (logs)
    • 2.7

Calibrator curve for validation data (generated in multiplex)

Leptin (LEP)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 6%
    • Between run precision Coefficient of Variation (CV)
    • 10%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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