Poly [ADP-ribose] polymerase 1 (PARP-1)

Links to databases

 

PARP-1 is an enzyme that catalyzes the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, and therefore plays an important role in the base excision repair (BER) pathway for DNA repair, as well as in the regualtion of several genes. PARP-1 also acts as a component of gene regulatory complexes with a variety of interaction partners, behaving in these cases as more of a classical-type transcription factor rather than a chromatin modifying protein.

Sample type

Low detection frequency in tested citrate and heparin plasma samples.

Analytical Measuring Range

    • LOD (pg/mL)
    • 61.04
    • LLOQ (pg/mL)
    • 122.07
    • ULOQ (pg/mL)
    • 125000
    • Hook (pg/mL)
    • 125000
    • Range (logs)
    • 3

Calibrator curve for validation data (generated in multiplex)

Poly [ADP-ribose] polymerase 1 (PARP-1)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 9%
    • Between run precision Coefficient of Variation (CV)
    • 11%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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