Granulocyte Colony-Stimulating Factor (G-CSF)
Links to databases
Granulocyte colony-stimulating factor, G-CSF (also known as pluripoietin) is a glycoprotein hormone that functions as a cytokine and induces granulocytes via stimulation of the bone marrow. In addition to this general role in hematopoiesis, G-CSF also functions as a neurotrophic factor, with multiple effects on neurons mediated via a receptor that is expressed in neurons in the brain and spinal cord. In this capacity, G-CSF is involved in inducing neurogenesis, enhancing neuroplasticity and inhibiting neronal apoptosis. Due these properties, G-CSF has been the subject of investigations to assess its potential as a treatments for neurological diseases such as cerebral ischemia. The protein has also been implicated in stroke.
Recommended sample types are human EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact firstname.lastname@example.org for more information.
NOTE: The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page.
Analytical Measuring Range
Calibrator curve generated in multiplex
- Within run precision Coefficient of Variation (CV)
- Between run precision Coefficient of Variation (CV)
Precision (repeatability) is calculated from linearized NPX values over LOD.
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.