Neuronal cell adhesion molecule (Nr-CAM)

Links to databases

Neuronal cell adhesion molecule (Nr-CAM) is ankyrin-binding protein that belongs to the immunoglobulin superfamily. Nr-CAM is essential for normal responses to cell-cell contacts in the brain and the peripheral nervous system and promotes directional signaling during axonal cone growth. This protein is also involved in neurite outgrowth in response to contactin binding, as well as in the formation and maintenance of the nodes of Ranvier on myelinated axons. Allelic variants in the gene encoding Nr-CAM have been linked to both autism and susceptibility to addiction behavior. There are also suggested links between Nr-CAM to some sleep disorders and to subependymal glioma. This protein is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during cell migration.

Sample type

Recommended sample types are human EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact support@olink.com for more information.

NOTE: The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page.

Analytical Measuring Range

    • LOD (pg/mL)
    • 3.81
    • LLOQ (pg/mL)
    • 3.81
    • ULOQ (pg/mL)
    • 31250
    • Hook (pg/mL)
    • 62500
    • Range (logs)
    • 3.9

Calibrator curve generated in multiplex

Neuronal cell adhesion molecule (Nr-CAM)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 5%
    • Between run precision Coefficient of Variation (CV)
    • 8%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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