T-cell leukemia / lymphoma protein 1A (TCL1A)

Links to databases

 

T-cell leukemia/lymphoma protein 1A (TCL1A), also known as Oncogene TCL-1, enhances the phosphorylation and activation of the AKT1, AKT2 and AKT3 kinases. TCL1A promotes nuclear translocation of AKT1 to enhance cell proliferation, stabilize mitochondrial membrane potential and promote cell survival. Chromosomal aberrations that activate TCL1A are associated with chronic T-cell leukemia.

Sample type

Recommended sample types are human EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact support@olink.com for more information.

NOTE: The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page.

Analytical Measuring Range

    • LOD (pg/mL)
    • 1.91
    • LLOQ (pg/mL)
    • 7.63
    • ULOQ (pg/mL)
    • 62500
    • Hook (pg/mL)
    • 125000
    • Range (logs)
    • 3.9

Calibrator curve generated in multiplex

T-cell leukemia / lymphoma protein 1A (TCL1A)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 9%
    • Between run precision Coefficient of Variation (CV)
    • 15%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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