Annexin A1 (ANXA1)

Links to databases

 

Annexin A1 belongs to a family of calcium-dependent phospholipid-binding proteins,and has roles in membrane fusion and exocytosis. It is principally located on the cytosolic face of the plasma membrane and exhibits phospholipase A2 inhibitory activity. The protein also plays a key role in the anti-inflammatory effects of glucocorticoid hormones, which increase ANXA1 synthesis. Annexin A1 has also generated interest as a potential target for cancer therapy due to its inhibition of the NF-?B signal pathway, which may otherwise protect tumor cells from apoptosis. ANXA1 has also been reported as a useful diagnostic protein marker for hairy cell leukemia, and as a potential tumor supressor in breast cancer.

Sample type

Detection frequency < 20% in tested normal EDTA plasma and serum.

Analytical Measuring Range

    • LOD (pg/mL)
    • 976.56
    • LLOQ (pg/mL)
    • 976.56
    • ULOQ (pg/mL)
    • 125000
    • Hook (pg/mL)
    • 500000
    • Range (logs)
    • 2.1

Calibrator curve generated in multiplex

Annexin A1 (ANXA1)

Precision

    • Within run precision Coefficient of Variation (CV)
    • 8%
    • Between run precision Coefficient of Variation (CV)
    • 16%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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