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Olink Target 96 Organ Damage
Casting a broader net to further explore the complexity of the human proteome
Complementing and expanding on our previous portfolio of disease area-focused biomarker panels, our exploratory series offers scientists the chance to cast a wider net in the quest to identify new biomarkers and relevant protein signatures, offering many new assays focused on important biological processes with wide-ranging clinical relevance.
The Organ Damage panel offers simultaneous analysis of 92 protein biomarkers using just 1 µL of biological sample, and all assays are subject to Olink’s strict technical validation and QC control procedures. The selection of protein biomarker assays is designed to provide the optimal dynamic range, as well as to focus on proteins relevant for processes involved in biological response to organ damage. Categorization of the proteins included in the panel was carried out via referral to widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET. The assays in this panel include proteins involved in key biological processes such as response to stress, regulation of cell proliferation, cell cycle, and cell death/apoptosis.
An alphabetical list of the 92 proteins with links to the individual biomarker pages containing additional information and assay validation data can be found at the bottom of this page.
Note: The protein list applies to the latest version of this panel (product number 95331), released on December 12, 2018. The assay for Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1), Uniprot P43629 replaces the assay for Vascular endothelial growth factor C (VEGFC), Uniprot P49767 from the previous version (product number 95330).
An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class (based on widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET) can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data. Please note that these classifications are intended for general guidance only and while correct at the time of publication, they are not updated in real-time and you are advised to always check the source databases in order to see the latest updates regarding the information for specific proteins.
Biological Process
Disease Area
Tissue Expression
Protein Class
A comprehensive list of all protein biomarkers that can be measured using the currently available biomarker panels can be seen on the biomarker library page.
Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>
If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.
The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.
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[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)
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5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)
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Adhesion G-protein coupled receptor G1 (ADGRG1)
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Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)
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Anterior gradient protein 2 homolog (AGR2)
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Apoptosis-inducing factor 1, mitochondrial (AIFM1)
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B-cell scaffold protein with ankyrin repeats (BANK1)
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BH3-interacting domain death agonist (BID)
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BMP and activin membrane-bound inhibitor homolog (BAMBI)
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C-type lectin domain family 1 member A (CLEC1A)
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C-type natriuretic peptide (NPPC)
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Calcitonin (CALCA)
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Calreticulin (CALR)
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Carbonic anhydrase 12 (CA12)
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Carbonic anhydrase 14 (CA14)
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Casein kinase I isoform delta (CSNK1D)
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Claspin (CLSPN)
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CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)
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Cocaine esterase (CES2)
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Contactin-2 (CNTN2)
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Corticoliberin (CRH)
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Desmoglein-4 (DSG4)
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Dipeptidyl aminopeptidase-like protein 6 (DPP6)
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DNA topoisomerase 2-beta (TOP2B)
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Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2)
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Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6)
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EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)
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Enteropeptidase (TMPRSS15)
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Epidermal growth factor-like protein 7 (EGFL7)
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Erbin (ERBIN)
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Erythropoietin (EPO)
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Fatty acid-binding protein 9 (FABP9)
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Forkhead box protein O1 (FOXO1)
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Fructose-2,6-bisphosphatase TIGAR (TIGAR)
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Hematopoietic prostaglandin D synthase (HPGDS)
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Inactive tyrosine-protein kinase 7 (PTK7)
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Integrin beta-1-binding protein 1 (ITGB1BP1)
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Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA)
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Kidney Injury Molecule (KIM1)
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Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1)
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Leukotriene A-4 hydrolase (LTA4H)
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Linker for activation of T-cells family member 2 (LAT2)
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Lutropin subunit beta (LHB)
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Macrophage erythroblast attacher (MAEA)
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Macrophage-capping protein (CAPG)
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Melanoma-associated antigen D1 (MAGED1)
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Methionine aminopeptidase 1 (METAP1)
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Mevalonate kinase (MVK)
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Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5)
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Mothers against decapentaplegic homolog 1 (SMAD1)
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NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)
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NEDD8 ultimate buster 1 (NUB1)
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Neutrophil cytosol factor 2 (NCF2)
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Nibrin (NBN)
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Nitric oxide synthase, endothelial (NOS3)
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Nucleobindin-2 (NUCB2)
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Parvalbumin alpha (PVALB)
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Paxillin (PXN)
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Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)
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Perilipin-1 (PLIN1)
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Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)
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Placenta growth factor (PGF)
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Platelet-derived growth factor C (PDGFC)
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Pleiotrophin (PTN)
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Plexin domain-containing protein 1 (PLXDC1)
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Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)
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Probetacellulin (BTC)
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Programmed cell death protein 1 (PDCD1)
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Prolow-density lipoprotein receptor-related protein 1 (LRP1)
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Proteasome subunit alpha type-1 (PSMA1)
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Protein amnionless (AMN)
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Protein enabled homolog (ENAH)
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Protein fosB (FOSB)
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Protein max (MAX)
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Protein phosphatase 1B (PPM1B)
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Ras association domain-containing protein 2 (RASSF2)
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Ras GTPase-activating protein 1 (RASA1)
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Receptor-type tyrosine-protein phosphatase eta (PTPRJ)
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Renin receptor (ATP6AP2)
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REST corepressor 1 (RCOR1)
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Retinoic acid receptor responder protein 1 (RARRES1)
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Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)
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Serpin A9 (SERPINA9)
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Serum paraoxonase/arylesterase 2 (PON2)
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Syntaxin-8 (STX8)
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Syntaxin-binding protein 3 (STXBP3)
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Troponin I, cardiac muscle (TNNI3)
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Tyrosine-protein kinase Fes/Fps (FES)
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Tyrosine-protein kinase Fgr (FGR)
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Tyrosine-protein kinase Yes (YES1)
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Vasohibin-1 (VASH1)
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Wiskott-Aldrich syndrome protein (WAS)