Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Links to databases


TGM2 (also known as Tissue transglutaminase) is a calcium-dependent protein-glutamine ?-glutamyltransferase that catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. TGM2 is found in both intracellular and extracellular locations, where it may play roles in apoptosis and cell adhesion, respectively. This protein is notable for being the autoantigen involved in coeliac disease (gluten intolerance).

Sample type

Analytical Measuring Range

Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (

    • LOD (pg/mL)
    • 61.04
    • LLOQ (pg/mL)
    • 61.04
    • ULOQ (pg/mL)
    • 125000
    • Hook (pg/mL)
    • 125000
    • Range (logs)
    • 3.3

Calibrator curve for validation data (generated in multiplex)

Protein-glutamine gamma-glutamyltransferase 2 (TGM2)


    • Within run precision Coefficient of Variation (CV)
    • 8%
    • Between run precision Coefficient of Variation (CV)
    • 12%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

View all CVD II panel biomarkers >

View all biomarkers >