Poly [ADP-ribose] polymerase 1 (PARP-1)
Links to databases
PARP-1 is an enzyme that catalyzes the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, and therefore plays an important role in the base excision repair (BER) pathway for DNA repair, as well as in the regualtion of several genes. PARP-1 also acts as a component of gene regulatory complexes with a variety of interaction partners, behaving in these cases as more of a classical-type transcription factor rather than a chromatin modifying protein.
Low detection frequency in tested citrate and heparin plasma samples.
Analytical Measuring Range
Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (https://www.olink.com/question/what-is-npx).
Calibrator curve for validation data (generated in multiplex)
- Within run precision Coefficient of Variation (CV)
- Between run precision Coefficient of Variation (CV)
Precision (repeatability) is calculated from linearized NPX values over LOD.
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.