Protein CYR61 (CYR61)

Links to databases


Protein CYR61 (CYR61), also known as CCN family member 1, is a secreted, extracellular matrix (ECM)-associated signaling protein. CYR61 regulates a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence. Developmentally, CYR61 is critical for cardiac morphogenesis, placental blood vessel formation and vascular integrity. The protein continues to have important roles post-development, specifically in inflammation and tissue repair. CYR61 is also of interest in many disease areas, with links to several conditions related to chronic inflammation, as well as to many different forms of cancer. It is thought to promote cancer cell proliferation, invasion, survival, epithelial?mesenchymal transition, and metastasis and has been shown to strongly induce angiogenesis in vivo. Conversely, the protein has also been shown to induce tumor cell apoptosis in some cases. CYR61 is also a prognostic marker for numerous types of cancer, with expression level correlations observed to multiple aspects of tumor progression, such as tumor stage, tumor size and lymph node positivity.

Sample type

Recommended sample types are EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact for more information.

Analytical Measuring Range

Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (

    • LOD (pg/mL)
    • 7.63
    • LLOQ (pg/mL)
    • 30.52
    • ULOQ (pg/mL)
    • 125000
    • Hook (pg/mL)
    • 500000
    • Range (logs)
    • 3.6

Calibrator curve generated in multiplex

Protein CYR61 (CYR61)


    • Within run precision Coefficient of Variation (CV)
    • 9%
    • Between run precision Coefficient of Variation (CV)
    • 15%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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