Methionine aminopeptidase 2 (MetAP 2)

Links to databases


Methionine aminopeptidase 2 (MetAP 2), also known as Initiation factor 2-associated 67 kDa glycoprotein, is a member of the dimetallohydrolase family. MetAP 2catalyzes the hydrolytic removal of N-terminal methionine residues from nascent proteins. MetAP 2 plays a vital role in tissue repair and protein degradation. There is also a significant correlation between enzymatic inhibition activity of MetAP2 and inhibition of cell growth, implicating an additional role in endothelial cell proliferation. As a result, there is interest in this protein as a potential target for the inhibition of angiogenesis for tumor therapy. Interestingly, MetAP2 also turns out to be the target of two groups of anti-angiogenic natural products, ovalicin and fumagillin.

Sample type

Recommended sample types are EDTA plasma and serum. A range of additional sample types are compatible with the technology (PEA), including citrate plasma, heparin plasma, cerebrospinal fluid, (CSF), tissue and cell lysates, fine needle biopsis, microdialysis fluid, cell culture media, dried blood spots, synovial fluid, saliva, plaque extract and microvesicles. Please note that protein expression levels are expected to vary in different sample types. Certain assays are differentially affected by interfering substances such as hemolysate. Download any of our Data Validation documents or contact for more information.

Analytical Measuring Range

Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (

    • LOD (pg/mL)
    • 244.14
    • LLOQ (pg/mL)
    • 244.14
    • ULOQ (pg/mL)
    • 62500
    • Hook (pg/mL)
    • 125000
    • Range (logs)
    • 2.4

Calibrator curve generated in multiplex

Methionine aminopeptidase 2 (MetAP 2)


    • Within run precision Coefficient of Variation (CV)
    • 7%
    • Between run precision Coefficient of Variation (CV)
    • 12%

Precision (repeatability) is calculated from linearized NPX values over LOD.

Biomarker Validation Data

Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.

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