Annexin A1 (ANXA1)
Links to databases
Annexin A1 belongs to a family of calcium-dependent phospholipid-binding proteins,and has roles in membrane fusion and exocytosis. It is principally located on the cytosolic face of the plasma membrane and exhibits phospholipase A2 inhibitory activity. The protein also plays a key role in the anti-inflammatory effects of glucocorticoid hormones, which increase ANXA1 synthesis. Annexin A1 has also generated interest as a potential target for cancer therapy due to its inhibition of the NF-?B signal pathway, which may otherwise protect tumor cells from apoptosis. ANXA1 has also been reported as a useful diagnostic protein marker for hairy cell leukemia, and as a potential tumor supressor in breast cancer.
Detection frequency < 20% in tested normal EDTA plasma and serum.
Analytical Measuring Range
Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (https://www.olink.com/question/what-is-npx).
Calibrator curve generated in multiplex
- Within run precision Coefficient of Variation (CV)
- Between run precision Coefficient of Variation (CV)
Precision (repeatability) is calculated from linearized NPX values over LOD.
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.