Increasing the Accuracy of Multiple Sclerosis Relapse Monitoring
Neurology, Protein biomarkers, Proteomics
In the Relapsing-Remitting form of Multiple Sclerosis (RRMS), a single biomarker (soluble neurofilament light chain or sNfL) is identified as a biomarker for inflammatory activity in MS, but is limited in its ability to identify relapses. Through screening several hundred proteins using Olink® technology, three additional protein biomarkers have been identified as an improved relapse-specific signature to monitor disease activity in RRMS patients.
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the nervous system (brain and spinal cord) causing the degradation of myelin, the protective insulating layer around nerve fibers. By disrupting the normal signaling to and from the brain, unpredictable symptoms develop: numbness, fatigue and mood changes, all the way up to pain, paralysis and/or blindness.
Nearly 1 million people in the United States and up to 2.8 million worldwide live with multiple sclerosis, which is the most common disabling disease of young adults. Current research indicates that a complex set of genetic and environmental factors play a role in its pathogenesis, including low levels of Vitamin D, infection with Epstein-Barr Virus and childhood obesity all implicated.