Using Olink’s human panels with non-human samples
We frequently get questions about whether Olink panels can be used for studies in other species. This is especially interesting for working with rodents because of the small sample volume required using Olink’s technology.
Please note: Olink has now developed a 92-plex panel specifically for use with mouse samples – see Olink® MOUSE EXPLORATORY. If you are interested in using any of the many Olink panels developed for use in humans, read on! We have also produced an application note, “Olink Mouse Exploratory – Pilot Studies” as well as a technical note, “Extending Olink’s Mouse Exploratory panel to studies in rats” – both available from our Document Download Center.
The assays in Olink’s human panels are all developed using antibodies targeted against human proteins. There is of course a certain level of antibody cross-reactivity between human proteins and their homologs in other species. Consequently, a certain proportion of assays in our human panels generate signals in samples of non-human origin. Please keep in mind , however, that the assays have not gone through the thorough validation process in other species that is the hallmark of Olink’s validation in human plasma & serum.
In case you are interested in using any of the Olink panels in non-human species at your own discretion, please contact your local Olink representative, or email us at firstname.lastname@example.org