• SCALLOP – genetics of the proteome

    The SCALLOP consortium is a collaborative framework for discovery and follow-up of genetic associations with proteins on the Olink Proteomics platform. To date, 19 PIs from 10 research institutions have joined the effort, which now comprises summary level data on SNP to protein level associations from almost 30,000 patients or controls. SCALLOP welcomes new members.

    For more information please contact Anders Mälarstig

    For the latest news about SCALLOP – view our news page

    Current work

    Each SCALLOP member works on human study collections from the general population, clinical trials or patients with certain diseases such as coronary artery disease, rheumatoid arthritis, bipolar disease, heart failure, dementias or metabolic syndrome. The aim of the SCALLOP consortium is to identify novel molecular connections and protein biomarkers that are causal in diseases. This work starts with identification of so called protein quantitative trait loci, pQTLs, which are robust connections between a gene variant and the levels of a protein.

    There are two types of pQTLs:

    • cis-pQTLs are variants that are proximal to the gene encoding the protein under study whereas trans-pQTLs are distal regulation of proteins via an often unknown path.
    • Trans-pQTLs can provide unique insights of molecular connections in human biology.

    Cis-pQTLs are strong instruments for determining if a protein biomarker for disease is causing disease or elevated or suppressed as a consequence of it. The SCALLOP consortium is currently underway with mapping novel pQTLs for several 100s of proteins in unprecedented sample sizes, something which will yield much deeper insights into the trans-regulation of plasma proteins than what has been possible to date.

    Operations

    To be a member of the SCALLOP consortium you have to be the PI of a study collection with Olink proteomics and genome-wide genotyping data. We also expect members to sign up to the Consortium Agreement, which manages conduct and authorships. Download the  Consortium Agreement here.

    The leadership for subprojects within the SCALLOP consortium rotates and members can take new ideas and suggestions for additional subprojects to the monthly steering committee meetings.

    SCALLOP uses a dedicated server for sharing of data. The server is set up under the Danish node of the TRYGGVE server structure. TRYGGVE allows sharing of sensitive data thanks to 2-step authorization procedures and high data security. Thanks to this structure SCALLOP is set up to move to individual-level data should the consortium wish to do so.

    Repository browser

    Acronym Design Website
    ASAP Aortic valve surgery www.ki.se/en/meds/team-per-eriksson
    BioFinder Dementia http://biofinder.se
    COMBINE Rheumatoid arthritis www.combinesweden.se/
    EpiHealth Prospective observational www.epihealth.se/For-scientists/
    Estonian Biobank Population based www.geenivaramu.ee/en/access-biobank 
    HELIC MANOLIS Population isolate www.helic.org/sites.html
    IMPROVE Prospective, metabolic syndrome www.ki.se/en/meds/team-hamsten
    INTERVAL Blood donors www.intervalstudy.org.uk/
    Kadoorie biobank Pancreatic cancer www.ckbiobank.org
    LifeLines Deep Population based www.lifelines.nl/researcher/biobank-lifelines/additional-studies/lifelines-deep
    MPP-RES Heart failure www.ludc.med.lu.se/malmoe-prevention-project-mpp/
    NSPHS Population isolate www.ncbi.nlm.nih.gov/pubmed/20568910
    ORCADES Population isolate www.orcades.ed.ac.uk/orcades/
    Pfizer trials (RA, UC, psoriasis) Clinical trials, RA www.pfizer.com
    PIVUS Prospective observational www.medsci.uu.se/pivus/
    STABILITY Acute coronary syndrome www.nejm.org/doi/full/10.1056/NEJMoa1315878#t=article 
    STANLEY Bipolar/depression www.ki.se/meb/stanleyswebic-studien
    ULSAM Prospective observational www.pubcare.uu.se/ulsam/
    VIS Population isolate www.ed.ac.uk/mrc-human-genetics-unit/research/qtl-group/

    pQTL publications and data from SCALLOP members

    Folkersen L, Fauman E, Sabater-Lleal M, Strawbridge R, Frånberg M, Sennblad B, Baldassarre D, Veglia F, Humphries S, Rauramaa R, de Faire U, Smit A, Giral P, Kurl S, Mannarino E, Enroth S, Johansson Å, Bosdotter Enroth S, Gustafsson S, Lind L, Lindgren C, Morris A, Giedraitis V, Silveira A, Franco-Cereceda A, Tremoli E, IMPROVE study group , Gyllensten U, Ingelsson E, Brunak S, Eriksson P, Ziemek D, Hamsten A and Mälarstig A. Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. (2017) PLOS Genetics 13(4), doi.org/10.1371/journal.pgen.1006706
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    Enroth S, Johansson Å, Bosdotter Enroth S and Ulf Gyllensten U. Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs. Nature Commun. (2014) Aug 22;5:4684. doi: 10.1038/ncomms5684.
    PubMed link >