Olink Signature Q100

A benchtop system for protein biomarker analysis

Olink® Signature Q100  is a newly developed instrument for readout of Olink® Target 96/48 and Olink® Focus protein biomarker panels. Previously, readout of these panels has been exclusively carried out using the multi-functional Fluidigm® Biomark™ instrument – Olink Signature Q100 now offers a new, dedicated solution for qPCR readout of Olink panels that will enable researchers to run Olink kits more easily and conveniently in their own labs.


Key features

  • Developed specifically for Olink Target and Focus protein biomarker panels
  • Low investment threshold, broadening access to high quality protein biomarker analysis to more researchers than ever before
  • User-focused design with intuitive interface, including integrated software and IFC loader
  • Small, compact footprint

Supported panels

  • Olink Target 96 panels are focused around a specific disease area or biological process and each enable the relative quantification of 92 carefully selected proteins across 90 samples simultaneously, using just 1 µL sample. This offers a uniquely flexible proteomics solution, with a library of over 1100 human proteins available via 14 different 96-plex panels.
  • Olink Target 48 Cytokine is the ultimate solution for targeted studies focused on inflammatory diseases or process. This panel enables analysis of 45 carefully selected proteins across 40 samples simultaneously from just 1 μL sample. Thanks to the provision of calibrators for each assay, Olink® Target 48 Cytokine also offers absolute quantification, providing data in both standard concentration (pg/mL) and relative concentration (NPX) units.
  • Olink Focus panels are available via custom projects with our R&D experts, and offer assays for up to 21 customer-selected proteins, with a choice of absolute or relative quantification.
  • Olink will continue to develop additional Target and custom panel offerings to further expand the utility of Olink Signature.
signature q100 video thumb

Olink® Signature Q100 is a desktop instrument that allows you to seamlessly utilize the Olink PEA protein analysis platform to get biological insights.

Lab workflow

Antibody pairs labelled with DNA oligonucleotides bind target antigen in solution, allowing hybridization and extension by DNA polymerase. This newly created piece of DNA barcode is amplified by standard PCR before transfer to an integrated microfluidic chip (IFC), which is loaded into the instrument for qPCR and data readout.


Technical specifications

  • Memory: 16 GB
  • Storage: 1 TB HDD
  • Ports: 3 USB (1 in front, 2 in back) 1 GB/sec Ethernet
  • Power requirements: 100–240V; 8.0 A


  • Height: 55 cm (21.6 in)
  • Width: 27 cm (10.6 in)
  • Depth: 27 cm (10.6 in)
  • Weight: 38 kg (83.6 lb)

Download technical specifications


Olink® NPX Signature software

Olink® NPX Signature is a data analysis software that is designed for the Olink Target analysis platform, including Olink Target 48, Olink Target 96, as well as for Olink Focus panels. It allows for importing data, validating data quality, and normalizing Olink data for subsequent statistical analysis.

Read more


Service Agreements to maintain, repair, and protect your equipment

Keep your instruments up and running with Olink services and support. Olink Signature Q100 Service Agreements offer faster response times, proactive instrument care, and savings on repairs. Maximize system up-time and reduce repair costs and turnaround time with one of our comprehensive service agreements.

Contact your Olink sales or support representative for more information on our service offerings.


Site Requirement Signature Q100

Are you prepared? To accommodate the instrument, you need to assess and prepare the site so that installation can be performed and operation of the Signature Q100 will be successful.

Download manual

Ordering or questions

Olink Signature Q 100 is now available for delivery. If you would like to place an order, or if you have any other questions regarding this product, please contact us using the form below.


Biomarker assays

~851 million

Protein data points generated


Publications listed on website


Certified Core Labs

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