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Olink Target 96 Cardiovascular II
Towards a better understanding of cardiovascular disease and personalized medicine
The Cardiovascular II (CVD II) panel is a high-throughput, multiplex immunoassay enabling analysis of 92 CVD-related protein biomarkers across 96 samples simultaneously. This high level of multiplexing is achieved without any compromise on data quality, thanks to our proprietary Proximity Extension Assay (PEA) technology.
This panel contains known human cardiovascular and inflammatory markers as well as some exploratory human proteins with great potential as new CVD markers, which were carefully selected in collaboration with leading experts in the field. Each analyte in the panel has been assessed in terms of sample material, specificity, precision, sensitivity, dynamic range, matrix effects and interference. The assays on this panel have been selected to focus on low-abundance proteins, and 1 µL of undiluted sample is used to measure the 92 biomarkers, as with previous panels.
An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class (based on widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET) can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data. Please note that these classifications are intended for general guidance only and while correct at the time of publication, they are not updated in real-time and you are advised to always check the source databases in order to see the latest updates regarding the information for specific proteins.
Biological Process
Disease Area
Tissue Expression
Protein Class
Note: Studies can be complemented with 92 additional established and exploratory CVD biomarkers using Proseek Multiplex CVD III. In this panel, assays are focused on high-abundance proteins.
Overview: Dynamic ranges of the two CVD panels.A comprehensive list of all protein biomarkers that can be measured using the currently available Proseek Multiplex panels can be seen on the biomarker library page.
Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>
If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Proseek Multiplex Analysis Service.
The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.
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2,4-dienoyl-CoA reductase, mitochondrial (DECR1)
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A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAM-TS13)
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ADM (ADM)
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Agouti-related protein (AGRP)
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Alpha-L-iduronidase (IDUA)
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Angiopoietin-1 (ANGPT1))
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Angiopoietin-1 receptor (TIE2)
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Angiotensin-converting enzyme 2 (ACE2)
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Bone morphogenetic protein 6 (BMP-6)
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Brother of CDO (BOC)
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C-C motif chemokine 17 (CCL17)
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C-C motif chemokine 3 (CCL3)
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C-X-C motif chemokine 1 (CXCL1)
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Carbonic anhydrase 5A, mitochondrial (CA5A)
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Carcinoembryonic antigenrelated cell adhesion molecule 8 (CEACAM8)
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Cathepsin L1 (CTSL1)
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CD40 ligand (CD40-L)
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Chymotrypsin C (CTRC)
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Decorin (DCN)
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Dickkopf-related protein 1 (Dkk-1)
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Fatty acid-binding protein, intestinal (FABP2)
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Fibroblast growth factor 21 (FGF21)
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Fibroblast growth factor 23 (FGF-23)
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Follistatin (FS)
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Galectin-9 (Gal-9)
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Gastric intrinsic factor (GIF)
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Gastrotropin (GT)
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Growth hormone (GH)
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Growth/differentiation factor 2 (GDF-2)
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Heat shock 27 kDa protein (HSP 27)
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Heme oxygenase 1 (HO-1)
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Hydroxyacid oxidase 1 (HAOX1)
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Interleukin-1 receptor antagonist protein (IL-1ra)
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Interleukin-1 receptor-like 2 (IL1RL2)
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Interleukin-17D (IL-17D)
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Interleukin-18 (IL-18)
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Interleukin-27 (IL-27)
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Interleukin-4 receptor subunit alpha (IL-4RA)
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Interleukin-6 (IL6)
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Kidney Injury Molecule (KIM1)
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Lactoylglutathione lyase (GLO1)
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Lectin-like oxidized LDL receptor 1 (LOX-1)
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Leptin (LEP)
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Lipoprotein lipase (LPL)
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Low affinity immunoglobulin gamma Fc region receptor II-b (IgG Fc receptor II-b)
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Lymphotactin (XCL1)
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Macrophage receptor MARCO (MARCO)
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Matrix metalloproteinase-12 (MMP-12)
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Matrix metalloproteinase-7 (MMP-7)
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Melusin (ITGB1BP2)
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Natriuretic peptides B (BNP)
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NF-kappa-B essential modulator (NEMO)
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Osteoclast-associated immunoglobulin-like receptor (hOSCAR)
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P-selectin glycoprotein ligand 1 (PSGL-1)
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Pappalysin-1 (PAPPA)
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Pentraxin-related protein PTX3 (PTX3)
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Placenta growth factor (PGF)
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Platelet-derived growth factor subunit B (PDGF subunit B)
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Poly [ADP-ribose] polymerase 1 (PARP-1)
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Polymeric immunoglobulin receptor (PIgR)
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Pro-interleukin-16 (IL16)
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Programmed cell death 1 ligand 2 (PD-L2)
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Proheparin-binding EGF-like growth factor (HB-EGF)
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Prolargin (PRELP)
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Prostasin (PRSS8 )
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Protein AMBP (AMBP)
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Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
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Proteinase-activated receptor 1 (PAR-1)
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Proto-oncogene tyrosine-protein kinase Src (SRC)
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Receptor for advanced glycosylation end products (RAGE)
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Renin (REN)
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Serine protease 27 (PRSS27)
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Serine/threonine-protein kinase 4 (STK4)
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Serpin A12 (SERPINA12)
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SLAM family member 5 (CD84)
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SLAM family member 7 (SLAMF7)
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Sortilin (SORT1)
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Spondin-2 (SPON2)
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Stem cell factor (SCF)
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Superoxide dismutase [Mn], mitochondrial (SOD2)
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T-cell surface glycoprotein CD4 (CD4)
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Thrombomodulin TM
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Thrombopoietin (THPO)
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Thrombospondin-2 (THBS2)
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Tissue factor (TF)
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TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2)
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Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
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Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)
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Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B)
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Tyrosine-protein kinase Mer (MERTK)
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V-set and immunoglobulin domain-containing protein 2 (VSIG2)
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Vascular endothelial growth factor D (VEGFD)