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Olink Target 96 Cardiovascular III
Towards a better understanding of cardiovascular disease and personalized medicine
The Cardiovascular III (CVD III) panel is a high-throughput, multiplex immunoassay enabling analysis of 92 CVD-related protein biomarkers across 96 samples simultaneously. This high level of multiplexing is achieved without any compromise on data quality, thanks to our proprietary Proximity Extension Assay (PEA) technology.
This panel contains known human cardiovascular and inflammatory markers as well as some exploratory human proteins with great potential as new CVD markers, which were carefully selected in collaboration with leading experts in the field. Each analyte in the panel has been assessed in terms of sample material, specificity, precision, sensitivity, dynamic range, matrix effects and interference. The assays on this panel have been selected to focus on high-abundance proteins, and 1 µL of a 1:100 dilution of sample is used to measure the 92 biomarkers.
Please Note: the CVD III panel uses a 1:100 dilution of sample, whereas our technical validation assays are performed in vitro using recombinant analytes . Technical validation data reported on the biomarker pages below, and in the data validation document for this panel are based on these in vitro assays. A multiplication factor of 100 should therefore be taken into consideration when comparing the addressable biological concentration to the in vitro validation data. (Sample dilution guidelines can be found in the User Manual.)
An overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class (based on widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET) can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data. Please note that these classifications are intended for general guidance only and while correct at the time of publication, they are not updated in real-time and you are advised to always check the source databases in order to see the latest updates regarding the information for specific proteins.
Biological Process
Disease Area
Tissue Expression
Protein Class
Note: Studies can be complemented with 92 additional established and exploratory CVD biomarkers using Proseek Multiplex CVD II. In this panel, assays are focused on low-abundance proteins.
Overview: Dynamic ranges of the two CVD panels.A comprehensive list of all protein biomarkers that can be measured using the currently available Proseek Multiplex panels can be seen on the biomarker library page.
Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>
If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Olink Analysis Service.
The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.
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Aminopeptidase N (AP-N)
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Azurocidin (AZU1
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Bleomycin hydrolase (BLM hydrolase)
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C-C motif chemokine 15 (CCL15)
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C-C motif chemokine 16 (CCL16)
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C-C motif chemokine 24 (CCL24)
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C-X-C motif chemokine 16 (CXCL16)
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Cadherin-5 (CDH5)
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Carboxypeptidase A1 (CPA1)
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Carboxypeptidase B (CPB1)
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Caspase-3 (CASP-3)
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Cathepsin D (CTSD)
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Cathepsin Z (CTSZ)
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CD166 antigen (ALCAM)
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Chitinase-3-like protein 1 (CHI3L1)
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Chitotriosidase-1 (CHIT1)
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Collagen alpha-1(I) chain (COL1A1)
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Complement component C1q receptor (CD93)
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Contactin-1 (CNTN1)
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Cystatin-B (CSTB)
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E-selectin (SELE)
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Elafin (PI3)
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Ephrin type-B receptor 4 (EPHB4)
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Epidermal growth factor receptor (EGFR )
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Epithelial cell adhesion molecule (Ep-CAM)
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Fatty acid-binding protein, adipocyte (FABP4)
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Galectin-3 (Gal-3)
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Galectin-4 (Gal-4)
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Granulins (GRN)
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Growth/differentiation factor 15 (GDF-15)
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Insulin-like growth factor-binding protein 1 (IGFBP-1)
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Insulin-like growth factor-binding protein 2 (IGFBP-2)
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Insulin-like growth factor-binding protein 7 (IGFBP-7)
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Integrin beta-2 (ITGB2)
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Intercellular adhesion molecule 2 (ICAM-2)
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Interleukin-1 receptor type 1 (IL-1RT1)
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Interleukin-1 receptor type 2 (IL-1RT2)
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Interleukin-17 receptor A (IL-17RA)
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Interleukin-18-binding protein (IL-18BP)
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Interleukin-2 receptor subunit alpha (IL2-RA)
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Interleukin-6 receptor subunit alpha (IL-6RA)
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Junctional adhesion molecule A (JAM-A)
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Kallikrein-6 (KLK6 )
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Low-density lipoprotein receptor (LDL receptor)
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Lymphotoxin-beta receptor (LTBR)
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Matrix extracellular phosphoglycoprotein (MEPE)
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Matrix metalloproteinase-2 (MMP-2)
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Matrix metalloproteinase-3 (MMP-3)
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Matrix metalloproteinase-9 (MMP-9)
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Metalloproteinase inhibitor 4 (TIMP4)
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Monocyte chemotactic protein 1 (MCP-1)
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Myeloblastin (PRTN3)
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Myeloperoxidase (MPO)
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Myoglobin (MB)
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N-terminal prohormone brain natriuretic peptide (NT-proBNP)
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Neurogenic locus notch homolog protein 3 (Notch 3)
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Osteopontin (OPN)
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Osteoprotegerin (OPG)
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P-selectin (SELP)
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Paraoxonase (PON3)
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Peptidoglycan recognition protein 1 (PGLYRP1)
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Perlecan (PLC)
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Plasminogen activator inhibitor 1 (PAI)
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Platelet endothelial cell adhesion molecule (PECAM-1)
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Platelet glycoprotein VI (GP6)
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Platelet-derived growth factor subunit A (PDGF subunit A)
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Proprotein convertase subtilisin/kexin type 9 (PCSK9)
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Protein delta homolog 1 (DLK-1)
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Pulmonary surfactant-associated protein D (PSP-D)
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Resistin (RETN)
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Retinoic acid receptor responder protein 2 (RARRES2)
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Scavenger receptor cysteine-rich type 1 protein M130 (CD163)
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Secretoglobin family 3A member 2 (SCGB3A2)
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Spondin-1 (SPON1)
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ST2 protein (ST2)
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Tartrate-resistant acid phosphatase type 5 (TR-AP)
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Tissue factor pathway inhibitor (TFPI)
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Tissue-type plasminogen activator (t-PA)
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Transferrin receptor protein 1 (TR)
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Trefoil factor 3 (TFF3)
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Trem-like transcript 2 protein (TLT-2)
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Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)
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Tumor necrosis factor receptor 1 (TNF-R1)
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Tumor necrosis factor receptor 2 (TNF-R2)
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Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)
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Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)
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Tumor necrosis factor receptor superfamily member 6 (FAS )
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Tyrosine-protein kinase receptor UFO (AXL)
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Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS-1)
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Urokinase plasminogen activator surface receptor (U-PAR)
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Urokinase-type plasminogen activator (uPA)
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von Willebrand factor (vWF)