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Olink Target 96 Neurology
Towards a better understanding of neurology and neurological diseases
While the science of neurology continues to make great progress, neurological diseases represent a massive and growing challenge for global healthcare, with more than one billion people worldwide estimated to suffer from the consequences of such disorders. The discovery of neurology-related protein biomarkers and identification of clinically relevant protein signatures may pave the way for better understanding and diagnosis of neurological disorders, and facilitate better targeted treatments.
Our Neurology panel provides a high-throughput, multiplex immunoassay enabling analysis of 92 neurology-related protein biomarkers across 96 samples simultaneously. This high level of multiplexing is achieved without any compromise on data quality, thanks to our proprietary Proximity Extension Assay (PEA) technology
The panel panel offers a mix of established markers related to neurobiological processes and neurological diseases (e.g. neural development, axon guidance, synaptic function, or specific conditions such as Alzheimer’s disease), as well as some more exploratory proteins with broader roles in processes such as cellular regulation, immunology, development and metabolism. This balanced selection provides an ideal basis for protein biomarker discovery in the neurology area. For optimal assay performance, each analyte in the panel has been assessed in terms of sample material, specificity, precision, sensitivity, dynamic range, matrix effects and interference. Of the 92 assays provided, 89 are new and unique to this panel, with just 3 biomarkers overlapping with other Olink panels.
News September 2018:
The panel is now updated to include the key neurological marker, Microtubule-associated protein tau (MAPT), Uniprot number P10636.
AAn overview of how the 92 biomarker assays in the panel are classified according to Biological Process, Disease Area, Tissue Expression and Protein Class (based on widely used public-access bioinformatic databases, including Uniprot, Human Protein Atlas, Gene Ontology (GO) and DisGeNET) can be seen in the charts below. These charts are interactive: click on a chart-bar or pie-segment to see the list of biomarkers in that classification. Each item in the list links to the detailed biomarker page with validation data. Please note that these classifications are intended for general guidance only and while correct at the time of publication, they are not updated in real-time and you are advised to always check the source databases in order to see the latest updates regarding the information for specific proteins.
Biological Process
Disease Area
Tissue Expression
Protein Class
A comprehensive list of all protein biomarkers that can be measured using the currently available Proseek Multiplex panels can be seen on the biomarker library page.
Note: A printable list of the biomarker assays available in this panel, as well as a full data validation document, can be downloaded from our Document download center >>
If you prefer not to run the assay yourself, let our experts here at Olink do this for you via our Analysis Service.
The biomarker pages linked to below include calibrator curves that show the performance of each assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens, with data presented as Normalized Protein eXpression (NPX) values plotted against protein concentration (in pg/mL). Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please view the FAQ.
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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
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Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP)
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BDNF/NT-3 growth factors receptor (NTRK2)
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Beta-nerve growth factor (Beta-NGF)
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Bone morphogenetic protein 4 (BMP-4)
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Brevican core protein (BCAN)
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Brorin (VWC2)
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C-type lectin domain family 1 member B (CLEC1B)
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C-type lectin domain family 10 member A (CLEC10A)
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Cadherin-3 (CDH3)
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Cadherin-6 (CDH6)
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Carboxypeptidase A2 (CPA2)
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Carboxypeptidase M (CPM)
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Cathepsin S (CTSS)
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Cell adhesion molecule 3 (CADM3)
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Cell surface glycoprotein CD200 receptor 1 (CD200R1)
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CMRF35-like molecule 1 (CLM-1)
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CMRF35-like molecule 6 (CLM-6)
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Contactin-5 (CNTN5)
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Cytotoxic and regulatory T-cell molecule (CRTAM)
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Dickkopf-related protein 4 (Dkk-4)
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Dipeptidyl peptidase 1 (CTSC)
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Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22)
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Disintegrin and metalloproteinase domain-containing protein 23 (ADAM 23)
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Draxin (DRAXIN)
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Ephrin type-B receptor 6 (EPHB6)
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Ephrin-A4 (EFNA4)
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Epithelial discoidin domain-containing receptor 1 (DDR1)
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Ezrin (EZR)
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Fc receptor-like protein 2 (FcRL2)
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Galectin-8 (gal-8)
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GDNF family receptor alpha-1 (GFR-alpha-1)
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GDNF family receptor alpha-3 (GDNFR-alpha-3)
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Glial cell line-derived neurotrophic factor (GDNF)
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Glypican-5 (GCP5)
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Granulocyte Colony-Stimulating Factor (G-CSF)
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Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha)
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Granzyme A (GZMA)
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Growth/differentiation factor 8 (GDF-8)
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Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)
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Interleukin-12 subunit beta, Interleukin-12 subunit alpha (IL-12B, IL-12A)
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Interleukin-5 receptor subunit alpha (IL-5R-alpha)
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Junctional adhesion molecule B (JAM-B)
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Kynureninase (KYNU)
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Latexin (LXN)
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Layilin (LAYN)
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Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)
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Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2)
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Linker for activation of T-cells family member 1 (LAT)
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Lysosome membrane protein 2 (SCARB2)
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Macrophage scavenger receptor types I and II (MSR1)
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MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1)
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Matrilin-3 (MATN3)
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Mesencephalic astrocyte-derived neurotrophic factor (MANF)
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Microtubule-associated protein tau (MAPT)
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N-acylethanolamine-hydrolyzing acid amidase (NAAA)
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Neprilysin (NEP)
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Netrin receptor UNC5C (UNC5C)
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Neuroblastoma suppressor of tumorigenicity 1 (NBL1)
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Neurocan core protein (NCAN)
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Neuronal cell adhesion molecule (Nr-CAM)
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Neuropilin-2 (NRP2)
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Neutral ceramidase (N-CDase)
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Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 (NMNAT1)
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NKG2D ligand 2 (N2DL-2)
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NT-3 growth factor receptor (NTRK3)
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OX-2 membrane glycoprotein (CD200)
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Platelet-derived growth factor receptor alpha (PDGF-R-alpha)
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Plexin-B1 (PLXNB1)
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Plexin-B3 (PLXNB3)
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Poliovirus receptor (PVR)
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Protogenin (PRTG)
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R-spondin-1 (RSPO1)
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Repulsive guidance molecule A (RGMA)
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RGM domain family member B (RGMB)
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Roundabout homolog 2 (ROBO2)
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Scavenger receptor class A member 5 (SCARA5)
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Scavenger receptor class F member 2 (SCARF2)
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Secreted frizzled-related protein 3 (sFRP-3)
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Serine/threonine-protein kinase receptor R3 (SKR3)
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Sialic acid-binding Ig-like lectin 9 (Siglec-9)
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Sialoadhesin (SIGLEC1)
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SPARC-related modular calcium-binding protein 2 (SMOC2)
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Sphingomyelin phosphodiesterase (SMPD1)
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Tenascin-R (TN-R)
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Testican-1 (SPOCK1)
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Thy-1 membrane glycoprotein (THY 1)
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Transmembrane protease serine 5 (TMPRSS5)
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Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)
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Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)
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Tumor necrosis factor receptor superfamily member 27 (EDA2R)
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WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 (WFIKKN1)